-
1
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
DOI 10.1126/science.284.5415.770
-
Artavanis-Tsakonas, S., Rand, M. D. and Lake, R. J. (1999). Notch signaling: Cell fate control and signal integration in development. Science 284, 770-776. (Pubitemid 29291335)
-
(1999)
Science
, vol.284
, Issue.5415
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
2
-
-
70549083563
-
Herding Hippos: Regulating growth in flies and man
-
Badouel, C., Garg, A. and McNeill, H. (2009). Herding Hippos: regulating growth in flies and man. Curr. Opin. Cell Biol. 21, 837-843.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 837-843
-
-
Badouel, C.1
Garg, A.2
McNeill, H.3
-
3
-
-
0030013445
-
The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions
-
Bettler, D., Pearson, S. and Yedvobnick, B. (1996). The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions. Genetics 143, 859-875. (Pubitemid 26172483)
-
(1996)
Genetics
, vol.143
, Issue.2
, pp. 859-875
-
-
Bettler, D.1
Pearson, S.2
Yedvobnick, B.3
-
4
-
-
10644276290
-
Drosophila, the golden bug, emerges as a tool for human genetics
-
Bier, E. (2005). Drosophila, the golden bug, emerges as a tool for human genetics. Nat. Rev. Genet. 6, 9-23.
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 9-23
-
-
Bier, E.1
-
5
-
-
41049102573
-
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
-
Chang, S., Bray, S. M., Li, Z., Zarnescu, D. C., He, C., Jin, P. and Warren, S. T. (2008). Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat. Chem. Biol. 4, 256-263.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 256-263
-
-
Chang, S.1
Bray, S.M.2
Li, Z.3
Zarnescu, D.C.4
He, C.5
Jin, P.6
Warren, S.T.7
-
6
-
-
33745239787
-
Biologically active molecules that reduce polyglutamine aggregation and toxicity
-
DOI 10.1093/hmg/ddl135
-
Desai, U. A., Pallos, J., Ma, A. A., Stockwell, B. R., Thompson, L. M., Marsh, J. L. and Diamond, M. I. (2006). Biologically active molecules that reduce polyglutamine aggregation and toxicity. Hum. Mol. Genet. 15, 2114-2124. (Pubitemid 43923401)
-
(2006)
Human Molecular Genetics
, vol.15
, Issue.13
, pp. 2114-2124
-
-
Desai, U.A.1
Pallos, J.2
Ma, A.A.K.3
Stockwell, B.R.4
Thompson, L.M.5
Marsh, J.L.6
Diamond, M.I.7
-
7
-
-
20444404651
-
Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene
-
Edgar, K. A., Belvin, M., Parks, A. L., Whittaker, K., Mahoney, M. B., Nicoll, M., Park, C. C., Winter, C. G., Chen, F., Lickteig, K. et al. (2005). Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene. Genetics 170, 161-171.
-
(2005)
Genetics
, vol.170
, pp. 161-171
-
-
Edgar, K.A.1
Belvin, M.2
Parks, A.L.3
Whittaker, K.4
Mahoney, M.B.5
Nicoll, M.6
Park, C.C.7
Winter, C.G.8
Chen, F.9
Lickteig, K.10
-
8
-
-
65549121943
-
Notch signaling: The core pathway and its posttranslational regulation
-
Fortini, M. E. (2009). Notch signaling: The core pathway and its posttranslational regulation. Dev. Cell 16, 633-647.
-
(2009)
Dev. Cell
, vol.16
, pp. 633-647
-
-
Fortini, M.E.1
-
9
-
-
0032869218
-
1998 Warkany Lecture: Signaling pathways in development
-
DOI 10.1002/(SICI)1096-9926(199910)60:4<226::AID-TERA7>3.0.CO;2-W
-
Gerhart, J. (1999). Warkany Lecture: Signaling pathways in development. Teratology 60, 226-239. (Pubitemid 29478911)
-
(1999)
Teratology
, vol.60
, Issue.4
, pp. 226-239
-
-
Gerhart, J.1
-
10
-
-
0037390535
-
Notch signaling and inherited disease syndromes
-
Gridley, T. (2003). Notch signaling and inherited disease syndromes. Hum. Mol. Genet. 12, R9-R13.
-
(2003)
Hum. Mol. Genet.
, vol.12
-
-
Gridley, T.1
-
11
-
-
33847206401
-
The Salvador-Warts-Hippo pathway - An emerging tumour-suppressor network
-
Harvey, K. and Tapon, N. (2007). The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nat. Rev. Cancer 7, 182-191.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 182-191
-
-
Harvey, K.1
Tapon, N.2
-
12
-
-
0033571390
-
Engineered truncations in the Drosophila Mastermind protein disrupt Notch pathway function
-
Helms, W., Lee, H., Ammerman, M., Parks, A. L., Muskavitch, M. A. and Yedvobnick, B. (1999). Engineered truncations in the Drosophila Mastermind protein disrupt Notch pathway function. Dev. Biol. 215, 358-374.
-
(1999)
Dev. Biol.
, vol.215
, pp. 358-374
-
-
Helms, W.1
Lee, H.2
Ammerman, M.3
Parks, A.L.4
Muskavitch, M.A.5
Yedvobnick, B.6
-
13
-
-
33845749100
-
Contribution of growth and cell cycle checkpoints to radiation survival in drosophila
-
DOI 10.1534/genetics.106.064477
-
Jaklevic, B., Uyetake, L., Lemstra, W., Chang, J., Leary, W., Edwards, A., Vidwans, S., Sibon, O. and Tin Su, T. (2006). Contribution of growth and cell cycle checkpoints to radiation survival in Drosophila. Genetics 174, 1963-1972. (Pubitemid 46011586)
-
(2006)
Genetics
, vol.174
, Issue.4
, pp. 1963-1972
-
-
Jaklevic, B.1
Uyetake, L.2
Lemstra, W.3
Chang, J.4
Leary, W.5
Edwards, A.6
Vidwans, S.7
Sibon, O.8
Tin, T.S.9
-
14
-
-
0034978088
-
A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters
-
DOI 10.1128/MCB.21.13.4337-4346.2001
-
Kitagawa, T., Oyama, T., Kawashima, B., Yedvobnick, B., Kumar, A., Matsuno, K. and Harigaya, K. (2001). A human protein with sequence similarity to Drosophila Mastermind coordinates the nuclear form of Notch and a CSL protein to build a transcriptional activator complex on target promoters. Mol. Cell. Biol. 21, 4337-4346. (Pubitemid 32565315)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.13
, pp. 4337-4346
-
-
Kitagawa, M.1
Oyama, T.2
Kawashima, T.3
Yedvobnick, B.4
Kumar, A.5
Matsuno, K.6
Harigaya, K.7
-
15
-
-
64249172203
-
The canonical Notch signaling pathway: Unfolding the activation mechanism
-
Kopan, R. and Ilagan, M. (2009). The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137, 216-233.
-
(2009)
Cell
, vol.137
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.2
-
16
-
-
1642382833
-
Notch signaling: Control of cell communication and cell fate
-
DOI 10.1242/dev.01074
-
Lai, E. C. (2004). Notch signaling: control of cell communication and cell fate. Development 131, 965-973. (Pubitemid 38380451)
-
(2004)
Development
, vol.131
, Issue.5
, pp. 965-973
-
-
Lai, E.C.1
-
17
-
-
61449208917
-
Towards structural elucidation of the gamma secretase complex
-
Li, H., Wolfe, M. S. and Selkoe, D. J. (2009). Towards structural elucidation of the gamma secretase complex. Structure 17, 326-334.
-
(2009)
Structure
, vol.17
, pp. 326-334
-
-
Li, H.1
Wolfe, M.S.2
Selkoe, D.J.3
-
18
-
-
50849087987
-
Mastermind-like transcriptional coactivators: Emerging roles in regulating cross talk among multiple signaling pathways
-
McElhinny, A. S., Li, J. L. and Wu, L. (2008). Mastermind-like transcriptional coactivators: emerging roles in regulating cross talk among multiple signaling pathways. Oncogene 27, 5138-5147.
-
(2008)
Oncogene
, vol.27
, pp. 5138-5147
-
-
McElhinny, A.S.1
Li, J.L.2
Wu, L.3
-
19
-
-
0033581027
-
Preventing neurodegeneration in the Drosophila mutant bubblegum
-
Min, K. T. and Benzer, S. (1999). Preventing neurodegeneration in the Drosophila mutant bubblegum. Science 284, 1985-1988.
-
(1999)
Science
, vol.284
, pp. 1985-1988
-
-
Min, K.T.1
Benzer, S.2
-
21
-
-
70449671729
-
Direct inhibition of the NOTCH transcription factor complex
-
Moellering, R. E., Cornejo, M., Davis, T. N., Del Bianco, C., Aster, J. C., Blacklow, S. C., Kung, A. L., Gilliland, D. G., Verdine, G. L. and Bradner, J. E. (2009). Direct inhibition of the NOTCH transcription factor complex. Nature 462, 182-188.
-
(2009)
Nature
, vol.462
, pp. 182-188
-
-
Moellering, R.E.1
Cornejo, M.2
Davis, T.N.3
Del Bianco, C.4
Aster, J.C.5
Blacklow, S.C.6
Kung, A.L.7
Gilliland, D.G.8
Verdine, G.L.9
Bradner, J.E.10
-
22
-
-
33644749306
-
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
-
Nam, Y., Sliz, P., Song, L., Aster, J. C. and Blacklow, S. C. (2006). Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124, 973-983.
-
(2006)
Cell
, vol.124
, pp. 973-983
-
-
Nam, Y.1
Sliz, P.2
Song, L.3
Aster, J.C.4
Blacklow, S.C.5
-
23
-
-
0008125299
-
Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster 1, Zygotic loci on the second chromosome
-
Nusslein-Volhard, C., Wieschaus, E. and Kluding, H. (1984). Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster 1, Zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193, 267-282.
-
(1984)
Roux's Arch. Dev. Biol.
, vol.193
, pp. 267-282
-
-
Nusslein-Volhard, C.1
Wieschaus, E.2
Kluding, H.3
-
24
-
-
53249114029
-
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease
-
Pallos, J., Bodai, L., Lukacsovich, T., Purcell, J. M., Steffan, J. S., Thompson, L. M. and Marsh, J. L. (2008). Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum. Mol. Genet. 17, 3767-3775.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 3767-3775
-
-
Pallos, J.1
Bodai, L.2
Lukacsovich, T.3
Purcell, J.M.4
Steffan, J.S.5
Thompson, L.M.6
Marsh, J.L.7
-
25
-
-
0034729722
-
Mastermind is a putative activator for Notch
-
Petcherski, A. G. and Kimble, J. (2000). Mastermind is a putative activator for Notch. Curr. Biol. 10, 471-473.
-
(2000)
Curr. Biol.
, vol.10
, pp. 471-473
-
-
Petcherski, A.G.1
Kimble, J.2
-
26
-
-
50849111710
-
Rational targeting of Notch signaling in cancer
-
Rizzo, P., Osipo, C., Foreman, K., Golde, T., Osborne, B. and Miele, L. (2008). Rational targeting of Notch signaling in cancer. Oncogene 27, 5124-5131.
-
(2008)
Oncogene
, vol.27
, pp. 5124-5131
-
-
Rizzo, P.1
Osipo, C.2
Foreman, K.3
Golde, T.4
Osborne, B.5
Miele, L.6
-
27
-
-
34248994604
-
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
-
DOI 10.1038/nchembio883, PII NCHEMBIO883
-
Sarkar, S., Perlstein, E. O., Imarisio, S., Pineau, S., Cordenier, A., Maglathlin, R. L., Webster, J. A., Lewis, T. A., O'Kane, C. J., Schreiber, S. L. et al. (2007). Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat. Chem. Biol. 3, 331-338. (Pubitemid 46789270)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.6
, pp. 331-338
-
-
Sarkar, S.1
Perlstein, E.O.2
Imarisio, S.3
Pineau, S.4
Cordenier, A.5
Maglathlin, R.L.6
Webster, J.A.7
Lewis, T.A.8
O'Kane, C.J.9
Schreiber, S.L.10
Rubinsztein, D.C.11
-
28
-
-
0025096132
-
The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers
-
Smoller, D., Friedel, C., Schmid, A., Bettler, D., Lam, L. and Yedvobnick, B. (1990). The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers. Genes Dev. 4, 1688-1700.
-
(1990)
Genes Dev.
, vol.4
, pp. 1688-1700
-
-
Smoller, D.1
Friedel, C.2
Schmid, A.3
Bettler, D.4
Lam, L.5
Yedvobnick, B.6
-
29
-
-
0035909330
-
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
-
DOI 10.1038/35099568
-
Steffan, J. S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y. Z., Greenwald, M. et al. (2001). Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413, 739-743. (Pubitemid 33009952)
-
(2001)
Nature
, vol.413
, Issue.6857
, pp. 739-743
-
-
Steffan, J.S.1
Bodai, L.2
Pallos, J.3
Poelman, M.4
McCampbell, A.5
Apostol, B.L.6
Kazantsev, A.7
Schmidt, E.8
Zhu, Y.-Z.9
Greenwald, M.10
Kurokawa, R.11
Housman, D.E.12
Jackson, G.R.13
Marsh, J.L.14
Thompson, L.M.15
-
30
-
-
49349097988
-
Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes
-
Talora, C., Campese, A. F., Bellavia, D., Felli, M. P., Vacca, A., Gulino, A. and Screpanti, I. (2008). Notch signaling and diseases: an evolutionary journey from a simple beginning to complex outcomes. Biochim. Biophys. Acta 1782, 489-497.
-
(2008)
Biochim. Biophys. Acta
, vol.1782
, pp. 489-497
-
-
Talora, C.1
Campese, A.F.2
Bellavia, D.3
Felli, M.P.4
Vacca, A.5
Gulino, A.6
Screpanti, I.7
-
31
-
-
18144392678
-
ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma
-
DOI 10.1158/0008-5472.CAN-04-4561
-
Vidal, M., Wells, S., Ryan, A. and Cagan, R. (2005). ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma. Cancer Res. 65, 3538-3541. (Pubitemid 40616327)
-
(2005)
Cancer Research
, vol.65
, Issue.9
, pp. 3538-3541
-
-
Vidal, M.1
Wells, S.2
Ryan, A.3
Cagan, R.4
-
32
-
-
0028986567
-
The Ras signaling pathway in Drosophila
-
Wassarman, D. A., Therrien, M. and Rubin, G. M. (1995). The Ras signaling pathway in Drosophila. Curr. Opin. Genet. Dev. 5, 44-50.
-
(1995)
Curr. Opin. Genet. Dev.
, vol.5
, pp. 44-50
-
-
Wassarman, D.A.1
Therrien, M.2
Rubin, G.M.3
-
33
-
-
77649214078
-
Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
-
Wells, S. A., Jr, Gosnell, J. E., Gagel, R. F., Moley, J., Pfister, D., Sosa, J. A., Skinner, M., Krebs, A., Vasselli, J. and Schlumberger, M. (2010). Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J. Clin. Oncol. 28, 767-772.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 767-772
-
-
Wells Jr., S.A.1
Gosnell, J.E.2
Gagel, R.F.3
Moley, J.4
Pfister, D.5
Sosa, J.A.6
Skinner, M.7
Krebs, A.8
Vasselli, J.9
Schlumberger, M.10
-
34
-
-
69249155013
-
Modeling glioma growth and invasion in Drosophila melanogaster
-
Witte, H. T., Jeibmann, A., Klämbt, C. and Paulus, W. (2009). Modeling glioma growth and invasion in Drosophila melanogaster. Neoplasia 11, 882-888.
-
(2009)
Neoplasia
, vol.11
, pp. 882-888
-
-
Witte, H.T.1
Jeibmann, A.2
Klämbt, C.3
Paulus, W.4
-
35
-
-
0033662392
-
MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors
-
Wu, L., Aster, J. C., Blacklow, S. C., Lake, R., Artavanis-Tsakonas, S. and Griffin, J. D. (2000). MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors. Nat. Genet. 4, 484-489.
-
(2000)
Nat. Genet.
, vol.4
, pp. 484-489
-
-
Wu, L.1
Aster, J.C.2
Blacklow, S.C.3
Lake, R.4
Artavanis-Tsakonas, S.5
Griffin, J.D.6
-
36
-
-
0025237332
-
The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis
-
Xu, T., Rebay, I., Fleming, R. J., Scottgale, T. N. and Artavanis-Tsakonas, S. (1990). The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. Genes Dev. 4, 464-475.
-
(1990)
Genes Dev.
, vol.4
, pp. 464-475
-
-
Xu, T.1
Rebay, I.2
Fleming, R.J.3
Scottgale, T.N.4
Artavanis-Tsakonas, S.5
-
37
-
-
22244460522
-
Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
-
Zeng, Q., Li, S., Chepeha, D. B., Giordano, T. J., Li, J., Zhang, H., Polverini, P. J., Nor, J., Kitajewski, J. and Wang, C. Y. (2005). Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 8, 13-23.
-
(2005)
Cancer Cell
, vol.8
, pp. 13-23
-
-
Zeng, Q.1
Li, S.2
Chepeha, D.B.3
Giordano, T.J.4
Li, J.5
Zhang, H.6
Polverini, P.J.7
Nor, J.8
Kitajewski, J.9
Wang, C.Y.10
-
38
-
-
20044390015
-
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo
-
Zhang, X., Smith, D. L., Meriin, A. B., Engemann, S., Russel, D. E., Roark, M., Washington, S. L., Maxwell, M. M., Marsh, J. L., Thompson, L. M. et al. (2005). A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc. Natl. Acad. Sci. USA 102, 892-897.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 892-897
-
-
Zhang, X.1
Smith, D.L.2
Meriin, A.B.3
Engemann, S.4
Russel, D.E.5
Roark, M.6
Washington, S.L.7
Maxwell, M.M.8
Marsh, J.L.9
Thompson, L.M.10
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