Combustion-derived nanoparticles: Mechanisms of pulmonary toxicity

Clinical and Experimental Pharmacology and Physiology

Volumn 34, Issue 10, 2007, Pages 1044-1050

  BéruBé, Kelly ^a   Balharry, Dominique ^a   Sexton, Keith ^a   Koshy, Lata ^a   Jones, Tim ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Carbon black; Combustion derived particles; Diesel exhaust; Fly ash; Nanoparticles; Pulmonary toxicity

Indexed keywords

CARBON; NANOPARTICLE; VOLATILE ORGANIC COMPOUND;

AIR POLLUTANT; CARDIOTOXICITY; CHEMICAL COMPOSITION; CHRONIC BRONCHITIS; COMBUSTION; CONFERENCE PAPER; DECOMPOSITION; DUST EXPOSURE; ENVIRONMENTAL EXPOSURE; EXHAUST GAS; FLY ASH; HUMAN; LONG TERM EXPOSURE; LUNG FIBROSIS; LUNG FUNCTION TEST; LUNG INFILTRATE; LUNG TOXICITY; NANOTOXICOLOGY; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; PARTICLE SIZE; PARTICULATE MATTER; PYROLYSIS; SUDDEN DEATH;

AIR POLLUTANTS; ANIMALS; CARBON; FIRES; HUMANS; LUNG DISEASES; NANOPARTICLES; PARTICULATE MATTER; SOOT;

EID: 34547975063     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04733.x     Document Type: Conference Paper

References (36)

1. BéruBé KA, Balharry D, Jones TP et al. Characterization of airborne particulate matter and related mechanisms of toxicity: An experimental approach. In : Ayres J, Maynard R, Richards R, eds. Air Pollution Reviews, Vol. 3. Imperial College Press, London. 2006 Ch 4.
2. Jones TP, BéruBé KA. Mineralogy and structure of pathogenic particles. In : Donaldson K, Borm P (eds). Particle Toxicology. CRC Press, Boca Raton 2007 Ch 2.
3. Donaldson K, Tran L, Jimenez A et al. Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure. Particle Fibre Toxicol. 2005 2 : 1 14.
4. Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005 113 : 823 39.
5. Committee on the Medical Effects of Air Pollution. Cardiovascular Disease and Air Pollution. Department of Health (UK), London. 2006.
6. Mauderly JL, Snipes MB, Barr EB et al. Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. Part I. Neoplastic and nonneoplastic lung lesions. Res. Rep. Health Eff. Inst. 1994 068-1 : 1 75.
7. Brockmann M, Fischer M, Muller KM. Exposure to carbon black: A cancer risk? Int. Arch. Occup. Environ. Health 1998 71 : 85 99.
8. Gardiner K. Effects on respiratory morbidity of occupational exposure to carbon black: A review. Arch. Environ. Health 1995 50 : 44 60.
9. Gardiner K, Trethowan NW, Harrington JM et al. Respiratory health effects of carbon black: A survey of European carbon black workers. Br. J. Ind. Med. 1993 50 : 1082 896.
10. Lewis AB, Taylor MD, Roberts JR et al. Role of metal-induced reactive oxygen species generation in lung responses caused by residual oil fly ash. J. Biosci. 2003 28 : 13 18.
11. Gardner SY, McGee JK, Kodavanti UP et al. Emission-particle-induced ventilatory abnormalities in a rat model of pulmonary hypertension. Environ. Health Perspect. 2004 112 : 872 8.
12. Antonini JM, Taylor MD, Leonard SS et al. Metal composition and solubility determine lung toxicity induced by residual oil fly ash collected from different sites within a power plant. Mol. Cell Biochem. 2004 255 : 257 65.
13. Ghio AJ, Silbajoris R, Carson JL et al. Biologic effects of oil fly ash. Environ. Health Perspect. 2002 110 : 89 94.
14. Gilmour MI, O'Connor S, Dick CA et al. Differential pulmonary inflammation and in vitro cytotoxicity of size fractionated fly ash particles from pulverized coal combustion. J. Air Waste Manag. Assoc. 2004 54 : 286 95.
15. Jimenez LA, Thompson J, Brown DA et al. Activation of NF-κB by PM10 occurs via an iron-mediated mechanism in the absence of IκB degradation. Toxicol. Appl. Pharmacol. 2000 166 : 101 10.
16. Brown DM, Donaldson K, Borm PJ et al. Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004 286 : L344 53.
17. Tamaoki J, Isono K, Takeyama K et al. Ultrafine carbon black particles stimulate proliferation of human airway epithelium via EGF receptor-mediated signaling pathway. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004 287 : L1127 33.
18. Iwai K, Adachi S, Takahashi M et al. Early oxidative DNA damages and late development of lung cancer in diesel exhaust-exposed rats. Environ. Res. 2000 84 : 255 64.
19. Nikula KJ, Snipes MB, Barr EB et al. Comparative pulmonary toxicities and carcinogenicities of chronically inhaled diesel exhaust and carbon-black in f344 rats. Fund. Appl. Toxicol. 1995 25 : 80 94.
20. Dasenbrock C, Peters L, Creutzenberg O et al. The carcinogenic potency of carbon particles with and without PAH after repeated intratracheal administration in the rat. Toxicol. Lett. 1996 88 : 15 21.
21. Maeng SH, Chung HW, Yu IJ et al. Changes of 8-OH-dG levels in DNA and its base excision repair activity in rat lungs after inhalation exposure to hexavalent chromium. Mutat. Res. 2003 539 : 109 16.
22. van Maanen JM, Borm PJ, Knaapen A et al. In vitro effects of coal fly ashes: Hydroxyl radical generation, iron release, and DNA damage and toxicity in rat lung epithelial cells. Inhal. Toxicol. 1999 11 : 1123 41.
23. Kleinjans JC, Janssen YM, van Agen B et al. Genotixicity of coal fly ash, assessed in vitro in Salmonella typhimurium and human lymphocytes, an in vivo in an occupationally exposed population. Mutat. Res. 1989 224 : 127 34.
24. BéruBé KA, Jones TP, Williamson BJ et al. Physicochemical characterization of diesel exhaust particles: Factors for assessing biological activity. Atmos. Environ. 1999 33 : 1599 614.
25. Godschalk RW, Moonen EJ, Schilderman PA et al. Exposure-route-dependent DNA adduct formation by polycyclic aromatic hydrocarbons. Carcinogenesis 2000 21 : 87 92.
26. Squadrito GL, Cueto R, Dellinger B et al. Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter. Free Radic. Biol. Med. 2001 31 : 1132 8.
27. Costa DL, Dreher KL. Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. Environ. Health Perspect. 1997 105 : 1053 60.
28. Inoue K, Takano H, Yanagisawa R et al. Effects of nanoparticles on antigen-related airway inflammation in mice. Respir. Res. 2005 6 : 106 18.
29. Lewis AB, Taylor JR, Roberts MD et al. Role of metal-induced reactive oxygen species generation in lung responses caused by residual oil fly ash. J. Biosci. 2003 28 : 13 18.
30. Seaton A, Soutar A, Crawford V et al. Particulate air pollution and the blood. Thorax 1999 54 : 1027 32.
31. Evans SA, Al-Mosawi A, Adams RA et al. Inflammation, oedema and peripheral blood changes in lung-compromised rats after instillation with combustion-derived and manufactured nanoparticles. Exp. Lung Res. 2006 32 : 1 16.
32. Nemmar A, Hoet PH, Vanquickenborne B et al. Passage of inhaled particles into the blood circulation in humans. Circulation 2002 105 : 411 14.
33. Nemmar A, Vanbilloen H, Hoylaerts MF et al. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am. J. Respir. Crit. Care Med. 2001 164 : 1665 8.
34. Nemmar A, Hoylaerts MF, Hoet PH et al. Possible mechanisms of the cardiovascular effects of inhaled particles: Systemic translocation and prothrombotic effects. Toxicol. Lett. 2004 149 : 243 53.
35. Seaton A, Dennekamp M. Ill-health associated with low concentrations of nitrogen dioxide: An effect of ultrafine particles? Thorax 2003 58 : 1012 15.
36. BéruBé KA, Whittaker A, Jones TP et al. London's killer smogs: How did they kill? Proc. R. Microsc. Soc. 2005 40 : 171 83.