Scaffold microarchitecture determines internal bone directional growth structure: A numerical study

Journal of Biomechanics

Volumn 43, Issue 13, 2010, Pages 2480-2486

  Sanz Herrera, J A ^a,b,c   Doblare M ^a,b   Garcia Aznar J M ^a,b  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Anisotropic scaffolds; Bone mechanobiology; Multiscale methods; Tissue engineering

Indexed keywords

ANISOTROPIC SCAFFOLDS; BONE REGENERATION; BONE TISSUE ENGINEERING; BONE TISSUE REGENERATION; CLINICAL APPLICATION; CLINICAL PRACTICES; DESIGN PARAMETERS; DIRECTIONAL GROWTH; FUNCTIONAL PERFORMANCE; IN-SILICO; MACROSCOPIC REGIONS; MICRO ARCHITECTURES; MICRO-STRUCTURAL; MULTI-SCALE APPROACHES; MULTISCALE METHOD; NUMERICAL STUDIES; REGENERATION RATE; SPATIAL DISTRIBUTION;

BONE; MICROSTRUCTURE; OPTICAL ANISOTROPY; SIZE DISTRIBUTION; TISSUE ENGINEERING; UNCERTAINTY ANALYSIS;

SCAFFOLDS;

TISSUE SCAFFOLD;

ANISOTROPY; ARTICLE; BONE GROWTH; BONE MATRIX; BONE REGENERATION; BONE STRUCTURE; BONE TISSUE; CELL INVASION; COMPUTER MODEL; CONTROLLED STUDY; MATHEMATICAL COMPUTING; MECHANICAL STRESS; MICROMORPHOLOGY; POROSITY; PRIORITY JOURNAL; PROCESS MODEL; QUANTITATIVE STUDY; STRUCTURE ANALYSIS; TISSUE ENGINEERING;

ANISOTROPY; BONE AND BONES; BONE REGENERATION; COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; POROSITY; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 77956467143     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2010.05.027     Document Type: Article

References (40)

1. Adachi T., Tsubota K.I., Tomita Y., Hollister S.J. Trabecular surface remodelling simulation for cancellous bone using microstructural voxel finite element models. J. Biomech. Eng.-T ASME 2001, 123:403-409.
2. Adachi T., Osako Y., Tanaka M., Hojo M., Hollister S.J. Framework for optimal design of porous scaffold microstructure by computational simulation of bone regeneration. Biomaterials 2006, 27:3964-3972.
3. Beaupré G.S., Orr T.E., Carter D.R. An approach for time-dependent bone modelling and remodelling: theoretical development. J. Orthop. Res. 1990, 8:651-661.
4. Bignon A., Chouteau J., Chevalier J., Fantozzi G., Carret J.P., Chavassieux P., Boivin G., Melin M., Hartmann D. Effect of micro- and macroporosity of bone substitutes on their mechanical properties and cellular response. J. Mater. Sci. Mater. Med. 2003, 14:1089-1097.
5. Brígido-Diego R., M as-Estell es J., Sanz J.A., García-Aznar J.M., Salmerón-Sánchez M. Polymer scaffolds with interconnected spherical pores and controlled architecture for tissue engineering. Fabrication, mechanical properties and finite element modelling. J. Biomed. Mater. Res. B 2007, 81:448-455.
6. de Groot K. Bioceramics consisting of calcium phosphate salts. Biomaterials 1980, 1:47-50.
7. Di Palma F., Guignandon A., Chamson A., Lafage-Proust M.H., Laroche N., Peyroche S., Vico L., Rattner A. Modulation of the responses of human osteoblast-like cell to physiologic mechanical strains by biomaterial surfaces. Biomaterials 2005, 26:4249-4257.
8. Engler A.J., Sen S., Sweeney H.L., Discher D.E. Matrix elasticity directs stem cell lineage specification. Cell 2006, 126:677-689.
9. Gopferich A. Polymer bulk erosion. Macromolecules 1997, 30:2598-2604.
10. Guldberg R.E., Hollister S.J., Charras G.T. The accuracy of digital image-based finite element models. J. Biomech. Eng. 1998, 27:433-444.
11. Gushue D.L., Houck J., Lerner A.M. Rabbit knee joint biomechanics: motion analysis and modelling of forces during hopping. J. Orthop. Res. 2005, 23:735-742.
12. Habibovic P., Yuan H., van der Valk C.M., Meijer G., van Blitterswijk C.A., de Groot K. 3D microenvironment as essential element for osteoinduction by biomaterials. Biomaterials 2005, 26:3565-3675.
13. Harpoon Lt. Manchester: Sharc UK, 2006.
14. Hing K.A., Annaz B., Saeed S., Revell P.A., Buckland T. Microporosity enhances bioactivity of synthetic bone graft substitutes. J. Mater. Sci. Mater. Med. 2005, 16:467-475.
15. Hollister S.J., Lin C.Y., Saito E., Lin C.Y., Schek R.D., Taboas J.M., Williams J.M., Partee B., Flanagan C.L., Diggs A., Wilke E.N., Van Lenthe G.H., Muller R., Wirtz T., Das S., Feinberg S.E., Krebsbach P.H. Engineering craniofacial scaffolds. Orthod. Craniofac. Res. 2005, 8:162-173.
16. Holy C.E., Fialkov J.A., Davies J.E., Shoichet M.S. Use of a biomimetic strategy to engineer bone. J. Biomed. Mater. Res. A 2003, 65:447-453.
17. Hutmacher D.W. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000, 21:2529-2543.
18. Ignatius A., Blessing H., Liedert A., Schmidt C., Neidlinger-Wilke C., Kaspar D., Friemert B., Claes L. Tissue engineering of bone: effects of mechanical strain on osteoblastic cells in type I collagen matrices. Biomaterials 2005, 26:311-318.
19. Jacobs, C.R., 1994. Numerical simulation of bone adaptation to mechanical loading. Ph.D. Thesis, Stanford University Press, California.
20. Kelly D.J., Prendergast P.J. Prediction of the optimal mechanical properties for a scaffold used in osteochondral defect repair. Tissue Eng. 2006, 12:2509-2519.
21. Le Nihouannen D., Daculsi G., Saffarzadeh A., Gauthier O., Delplace S., Pilet P., Layrolle P. Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles. Bone 2005, 36:1086-1093.
22. Lewandowska-Szumiel M., Sikorski K., Szummer A., Lewandowski Z., Marczynski W. Osteoblast response to the elastic strain of metallic support. J. Biomech. 2007, 40:554-560.
23. Lin A.S., Barrows T.H., Cartmell S.H., Guldberg R.E. Microarchitectural and mechanical characterization of oriented porous polymer scaffolds. Biomaterials 2003, 24:481-489.
24. Lipowiecki M., Brabazon D. Design of bone scaffolds structures for rapid prototyping with increased strength and osteoconductivity. Adv. Mater. Res. 2010, 83-86:914-922.
25. Mathieu L.M., Mueller T.L., Bourban P.E., Pioletti D.P., Muller R., Manson J.A.E. Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering. Biomaterials 2006, 27:905-916.
26. Mimics Materialise. Mimics Materialise NV v10.0, 2006.
27. Okuda T., Ioku K., Yonezawa I., Minagi H., Kawachi G., Gonda Y., Murayama H., Shibata Y., Minami S., Kamihira S., Kurosawa H., Ikeda T. The effect of microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue. Biomaterials 2007, 28:2612-2621.
28. Pavlin D., Gluhak-Heinrich J. Effect of mechanical loading on periodontal cells. Crit. Rev. Oral Biol. Med. 2001, 12:414-424.
29. Sanz-Herrera J.A., García-Aznar J.M., Doblaré M. A mathematical model for bone tissue regeneration inside a specific type of scaffold. Biomech. Modeling Mechanobiol. 2008, 7:355-366.
30. Sanz-Herrera J.A., Kasper C., van Griensven M., García-Aznar J.M., Ochoa I., Doblaré M. Mechanical and flow characterization of Sponceram carriers: evaluation by homogenization theory and experimental validation. J. Biomed. Mater. Res. B Appl. Biomater. 2008, 87:42-48.
31. Sanz-Herrera J.A., García-Aznar J.M., Doblaré M. Micro-macro numerical modelling of bone regeneration in tissue engineering. Comput. Method. Appl. M. 2008, 197:3092-3107.
32. Sanz-Herrera J.A., García-Aznar J.M., Doblaré M. On scaffold designing for bone regeneration: a computational multiscale approach. Acta Biomater. 2009, 5:219-229.
33. Sanz-Herrera J.A., García-Aznar J.M., Doblaré M. A mathematical approach to bone tissue engineering. Philos. Trans. A Math. Phys. Eng. Sci. 2009, 367:2055-2078.
34. Savarino L., Baldini N., Greco M., Capitani O., Pinna S., Valentini S., Lombardo B., Esposito M.T., Pastore L., Ambrosio L., Battista S., Causa F., Zeppetelli S., Guarino V., Netti P.A. The performance of poly-epsilon-caprolactone scaffolds in a rabbit femur model with and without autologous stromal cells and BMP4. Biomaterials 2007, 28:3101-3109.
35. Stevens M.M., George J.H. Exploring and engineering the cell surface interface. Science 2005, 310:1135-1138.
36. Suquet P.M. Elements of homogenization for inelastic solid mechanics. Trends and applications of pure mathematics to mechanics. Homogenization Techniques for Composite Media, Lecture Notes in Physics 272 1987, 193-278. Springer, Berlin. E. Sanchez-Palencia, A. Zaoui (Eds.).
37. Tang L., Lin Z., Yong-Ming L. Effects of different magnitudes of mechanical strain on osteoblasts in vitro. Biochem. Biophys. Res. Commun. 2006, 344:122-128.
38. Tate M.L.K., Steck R., Anderson E.J. Bone as an inspiration for a novel class of mechanoactive materials. Biomaterials 2009, 30:133-140.
39. Woodard J.R., Hilldore A.J., Sheeny K.L., Park C.J., Morgan A.W., Eurell J.A.C., Sherrie G.C., Wheeler M.B., Jamison R.D., Johnson A.J.W. The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity. Biomaterials 2007, 28:45-54.
40. Yamasaki N., Hirao M., Nanno K., Sugiyasu K., Tamai N., Hashimoto N., Yoshikawa H., Myoui A. A comparative assessment of synthetic ceramic bone substitutes with different composition and microstructure in rabbit femoral condyle model. J. Biomed. Mater. Res. B Appl. Biomater. 2009, 91:788-798.