Design of bone scaffolds structures for rapid prototyping with increased strength and osteoconductivity

Advanced Materials Research

Volumn 83-86, Issue , 2010, Pages 914-922

  Lipowiecki, Marcin ^a   Brabazon, Dermot ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

Bone scaffold; Osteoconductivity; Porosity; Rapid prototyping

Indexed keywords

BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; BONE REMODELLING; BONE SCAFFOLDS; BONE TISSUE REGENERATION; CORTICAL BONE; FINITE ELEMENT SOFTWARE; GEOMETRIC CONSTRAINT; MACROPORES; MANUFACTURING SYSTEM; MECHANICAL STRENGTH; OSTEOCONDUCTIVE; OSTEOCONDUCTIVITY; POROUS ARCHITECTURES; SOLID EDGE; SOLID MODELLING; STRESS-STRAIN RESPONSE; TRABECULAR STRUCTURE; UNIT CELLS;

BIOMECHANICS; BONE; COMPUTER SOFTWARE; CONCURRENT ENGINEERING; JOB ANALYSIS; MECHANICAL PROPERTIES; PROTEINS; RAPID PROTOTYPING; THREE DIMENSIONAL;

SCAFFOLDS;

EID: 75849136334     PISSN: 10226680     EISSN: None     Source Type: Book Series    
DOI: 10.4028/www.scientific.net/AMR.83-86.914     Document Type: Conference Paper

References (28)

1. P. Lal, and W. Sun, Computer modeling approach for microsphere-packed bone scaffold, Computer-Aided Design, vol. 36 (2004), 487-497.
2. B. Starly, W. Lau, T. Bradbury, and W. Sun, Internal architecture design and freeform fabrication of tissue replacement structures, Computer-Aided Design, vol. 38 (2006), 115-124.
3. M.J. Mondrinos, R. Dembzynski, L. Lu, V.K.C. Byrapogu, D.M. Wootton, P.I. Lelkes, and J. Zhou, Porogen-based solid freeform fabrication of polycaprolactone-calcium phosphate scaffolds for tissue engineering, Biomaterials, vol. 27 (2006), 4399-4408.
4. K.F. Leong, C.K. Chua, N. Sudarmadji, and W.Y. Yeong, Engineering functionally graded tissue engineering scaffolds, Journal of the Mechanical Behavior of Biomedical Materials, vol. 1 (2008), 140-152.
5. E. Saiz, L. Gremillard, G. Menendez, P. Miranda, K. Gryn, and A.P. Tomsia, Preparation of porous hydroxyapatite scaffolds, Materials Science and Engineering: C, vol. 27 (2007), 546-550.
6. L. Liulan, H. Qingxi, H. Xianxu, and X. Gaochun, Design and Fabrication of Bone Tissue Engineering Scaffolds via Rapid Prototyping and CAD, Journal of Rare Earths, vol. 25 (2007), 379-383.
7. B.-S. Kim, and D.J. Mooney, Development of biocompatible synthetic extracellular matrices for tissue engineering, Trends in Biotechnology, vol. 16 (1998), 224-230.
8. W.-Y. Yeong, C.-K. Chua, K.-F. Leong, and M. Chandrasekaran, Rapid prototyping in tissue engineering: challenges and potential, Trends in Biotechnology, vol. 22 (2004), 643-652.
9. C. Qu, Q.-H. Qin, and Y. Kang, A hypothetical mechanism of bone remodeling and modeling under electromagnetic loads, Biomaterials, vol. 27 (2006), 4050-4057.
10. S. Tayyar, P.S. Weinhold, R.A. Butler, J.C. Woodard, L.D. Zardiackas, K.R. St. John, J.M. Bledsoe, and J.A. Gilbert, Computer simulation of trabecular remodeling using a simplified structural model, Bone, vol. 25 (1999), 733-739.
11. M. Charles-Harris, S. del Valle, E. Hentges, P. Bleuet, D. Lacroix, and J.A. Planell, Mechanical and structural characterisation of completely degradable polylactic acid/calcium phosphate glass scaffolds, Biomaterials, vol. 28 (2007), 4429-4438.
12. W. Helen, and J.E. Gough, Cell viability, proliferation and extracellular matrix production of human annulus fibrosus cells cultured within PDLLA/Bioglass® composite foam scaffolds in vitro, Acta Biomaterialia, vol. 4 (2008), 230-243.
13. Y. Zhang, Y. Wang, B. Shi, and X. Cheng, A platelet-derived growth factor releasing chitosan/coral composite scaffold for periodontal tissue engineering, Biomaterials, vol. 28 (2007), 1515-1522.
14. H.H. Xu, and C.G. Simon, Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility, Biomaterials, vol. 26 (2005), 1337-1348.
15. P. Giannoudis, C. Tzioupis, T. Almalki, and R. Buckley, Fracture healing in osteoporotic fractures: Is it really different?: A basic science perspective, Scientific basis of fracture healing: an update, vol. 38 (2007), S90-S99.
16. D. Lacroix, and P.J. Prendergast, A mechano-regulation model for tissue differentiation during fracture healing: analysis of gap size and loading, Journal of Biomechanics, vol. 35 (2002), 1163-1171.
17. Z. Wu, W. Lei, Y. Hu, H. Wang, S. Wan, Z. Ma, H. Sang, S. Fu, and Y. Han, Effect of ovariectomy on BMD, micro-architecture and biomechanics of cortical and cancellous bones in a sheep model, Medical Engineering & Physics, vol. In Press, Corrected Proof.
18. B.C. Tellis, J.A. Szivek, C.L. Bliss, D.S. Margolis, R.K. Vaidyanathan, and P. Calvert, Trabecular scaffolds created using micro CT guided fused deposition modeling, Materials Science and Engineering: C, vol. 28 (2008), 171-178.
19. G.E. Ryan, A.S. Pandit, and D.P. Apatsidis, Porous titanium scaffolds fabricated using a rapid prototyping and powder metallurgy technique, Biomaterials, vol. 29 (2008), 3625-3635.
20. A.S. Lin, T.H. Barrows, S.H. Cartmell, and R.E. Guldberg, Microarchitectural and mechanical characterization of oriented porous polymer scaffolds, Biomaterials, vol. 24 (2003), 481-489.
21. M. Wettergreen, B. Bucklen, W. Sun, and M. Liebschner, Computer-Aided Tissue Engineering of a Human Vertebral Body, Annals of Biomedical Engineering, vol. 33 (2005), 1333-1343.
22. A.C. Jones, C.H. Arns, A.P. Sheppard, D.W. Hutmacher, B.K. Milthorpe, and M.A. Knackstedt, Assessment of bone ingrowth into porous biomaterials using MICRO-CT, Biomaterials, vol. 28 (2007), 2491-2504.
23. J.R. Woodard, A.J. Hilldore, S.K. Lan, C.J. Park, A.W. Morgan, J.A.C. Eurell, S.G. Clark, M.B. Wheeler, R.D. Jamison, and A.J. Wagoner Johnson, The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity, Biomaterials, vol. 28 (2007), 45-54.
24. V. Karageorgiou, and D. Kaplan, Porosity of 3D biomaterial scaffolds and osteogenesis, Biomaterials, vol. 26 (2005), 5474-5491.
25. S. Bose, J. Darsell, M. Kintner, H. Hosick, and A. Bandyopadhyay, Pore size and pore volume effects on alumina and TCP ceramic scaffolds, Materials Science and Engineering: C, vol. 23 (2003), 479-486.
26. P. Mc Donnell, M.A. Liebschner, W. Tawackoli, and P.E. Mc Hugh, Vibrational testing of trabecular bone architectures using rapid prototype models, Medical Engineering & Physics, vol. In Press, Corrected Proof.
27. X.J. Wang, X.B. Chen, P.D. Hodgson, and C.E. Wen, Elastic modulus and hardness of cortical and trabecular bovine bone measured by nanoindentation, Transactions of Nonferrous Metals Society of China, vol. 16 (2006), s744-s748.
28. J.Y. Rho, R.B. Ashman, and C.H. Turner, Young's modulus of trabecular and cortical bone material: Ultrasonic and microtensile measurements, Journal of Biomechanics, vol. 26 (1993), 111-119.