Deregulation of the Sod1 and Nd1 genes in mouse fetal oocytes exposed to mono-(2-ethylhexyl) phthalate (MEHP)

Reproductive Toxicology

Volumn 30, Issue 3, 2010, Pages 387-392

  Bonilla, Edmundo ^a   del Mazo, Jesús ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

Fetal oocytes; Gene expression; MEHP, mono (2 ethylhexyl) phthalate; Mitochondrial respiratory chain; Nd1, NADH ubiquinone oxidoreductase chain 1; Reproductive toxicology; Sod1, Cu Zn superoxide dismutase

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; FETOTOXICITY; FETUS; GENE CONTROL; GENE EXPRESSION; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRENATAL EXPOSURE; UPREGULATION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DIETHYLHEXYL PHTHALATE; ENVIRONMENTAL POLLUTANTS; FEMALE; FETAL DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; OOCYTES; OVARY; PROMOTER REGIONS, GENETIC; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUPEROXIDE DISMUTASE; UP-REGULATION;

MURINAE;

EID: 77956447559     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2010.04.008     Document Type: Article

References (41)

1. Fabjan E., Hulzebos E., Mennes W., Piersma A.H. A category approach for reproductive effects of phthalates. Crit Rev Toxicol 2006, 36:695-726.
2. Bornehag C.G., Sundell J., Weschler C.J., Sigsgaard T., Lundgren B., Hasselgren M., et al. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Environ Health Perspect 2004, 112:1393-1397.
3. Wams T.J. Diethylhexylphthalate as an environmental contaminant-a review. Sci Total Environ 1987, 66:1-16.
4. Doull J., Cattley R., Elcombe C., Lake B.G., Swenberg J., Wilkinson C., et al. A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines. Regul Toxicol Pharmacol 1999, 29:327-357.
5. Hong Y.C., Park E.Y., Park M.S., Ko J.A., Oh S.Y., Kim H., et al. Community level exposure to chemicals and oxidative stress in adult population. Toxicol Lett 2009, 184:139-144.
6. Lovekamp T.N., Davis B.J. Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. Toxicol Appl Pharmacol 2001, 172:217-224.
7. Kleinsasser N.H., Harreus U.A., Kastenbauer E.R., Wallner B.C., Sassen A.W., Staudenmaier R., et al. Mono(2-ethylhexyl)phthalate exhibits genotoxic effects in human lymphocytes and mucosal cells of the upper aerodigestive tract in the comet assay. Toxicol Lett 2004, 148:83-90.
8. Melnick R.L., Brody C., DiGangi J., Huff J. The IARC evaluation of DEHP excludes key papers demonstrating carcinogenic effects. Int J Occup Environ Health 2003, 9:400-402.
9. Macdonald N., Chevalier S., Tonge R., Davison M., Rowlinson R., Young J., et al. Quantitative proteomic analysis of mouse liver response to the peroxisome proliferator diethylhexylphthalate (DEHP). Arch Toxicol 2001, 75:415-424.
10. Mylchreest E., Wallace D.G., Cattley R.C., Foster P.M. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation. Toxicol Sci 2000, 55:143-151.
11. Latini G., Verrotti A., De Felice C. DI-2-ethylhexyl phthalate and endocrine disruption: a review. Curr Drug Targets 2004, 4:37-40.
12. Zacharewski T.R., Meek M.D., Clemons J.H., Wu Z.F., Fielden M.R., Matthews J.B. Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicol Sci 1998, 46:282-293.
13. Moore R.W., Rudy T.A., Lin T.M., Ko K., Peterson R.E. Abnormalities of sexual development in male rats with in utero and lactational exposure to the antiandrogenic plasticizer Di(2-ethylhexyl) phthalate. Environ Health Perspect 2001, 109:229-237.
14. Fisher J.S., Macpherson S., Marchetti N., Sharpe R.M. Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum Reprod 2003, 18:1383-1394.
15. Andrade A.J., Grande S.W., Talsness C.E., Grote K., Golombiewski A., Sterner-Kock A., et al. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): effects on androgenic status, developmental landmarks and testicular histology in male offspring rats. Toxicology 2006, 225:64-74.
16. Oishi S. Strain differences in susceptibility to di-2-ethylhexyl phthalate-induced testicular atrophy in mice. Toxicol Lett 1993, 66:47-52.
17. Gray L.E., Ostby J., Furr J., Price M., Veeramachaneni D.N., Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci 2000, 58:350-365.
18. Hallmark N., Walker M., McKinnell C., Mahood I.K., Scott H., Bayne R., et al. Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human. Environ Health Perspect 2007, 115:390-396.
19. Akingbemi B.T., Ge R., Klinefelter G.R., Zirkin B.R., Hardy M.P. Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. Proc Natl Acad Sci USA 2004, 101:775-780.
20. Ge R.S., Chen G.R., Tanrikut C., Hardy M.P. Phthalate ester toxicity in Leydig cells: developmental timing and dosage considerations. Reprod Toxicol 2007, 23:366-373.
21. Davis B.J., Weaver R., Gaines L.J., Heindel J.J. Mono-(2-ethylhexyl) phthalate suppresses estradiol production independent of FSH-cAMP stimulation in rat granulosa cells. Toxicol Appl Pharmacol 1994, 128:224-228.
22. Laskey J.W., Berman E. Steroidogenic assessment using ovary culture in cycling rats: effects of bis(2-diethylhexyl)phthalate on ovarian steroid production. Reprod Toxicol 1993, 7:25-33.
23. Anas M.K., Suzuki C., Yoshioka K., Iwamura S. Effect of mono-(2-ethylhexyl) phthalate on bovine oocyte maturation in vitro. Reprod Toxicol 2003, 17:305-310.
24. Bonilla E., del Mazo J. Deregulation of gene expression in fetal oocytes exposed to doxorubicin. Biochem Pharmacol 2003, 65:1701-1707.
25. De Felici M., Dolci S. Cellular interactions of mouse fetal germ cells in in vitro systems. Curr Top Dev Biol 1987, 23:147-162.
26. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J Mol Biol 1990, 215:403-410.
27. Bustin S.A. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 2000, 25:169-193.
28. Smith A.P., Polley S., Wells S., Stewart M., Vizor L., Humphreys J., et al. Analysis of breeding and pathology helps refine management practices of a large-scale N'-ethyl-N'-nitrosourea mouse mutagenesis programme. Lab Anim 2009, 43:1-10.
29. Rozen S., Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Meth Mol Biol 2000, 132:365-386.
30. Leemans R., Egger B., Loop T., Kammermeier L., He H., Hartmann B., et al. Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arrays. Proc Natl Acad Sci USA 2000, 97:12138-12143.
31. Ding H., Hashem M., Triggle C. Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: changes in expression of NADPH oxidase subunits and eNOS. Eur J Pharmacol 2007, 561:121-128.
32. Kavlock R., Boekelheide K., Chapin R., Cunningham M., Faustman E., Foster P., et al. NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reprod Toxicol 2002, 16:529-653.
33. Richburg J.H., Nanez A., Gao H. Participation of the Fas-signaling system in the initiation of germ cell apoptosis in young rat testes after exposure to mono-(2-ethylhexyl) phthalate. Toxicol Appl Pharmacol 1999, 160:271-278.
34. Treinen K.A., Dodson W.C., Heindel J.J. Inhibition of FSH-stimulated cAMP accumulation and progesterone production by mono(2-ethylhexyl) phthalate in rat granulosa cell cultures. Toxicol Appl Pharmacol 1990, 106:334-340.
35. Davis B.J., Maronpot R.R., Heindel J.J. Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats. Toxicol Appl Pharmacol 1994, 128:216-223.
36. Takai R., Hayashi S., Kiyokawa J., Iwata Y., Matsuo S., Suzuki M., et al. Collaborative work on evaluation of ovarian toxicity. 10) Two- or four-week repeated dose studies and fertility study of di-(2-ethylhexyl) phthalate (DEHP) in female rats. J Toxicol Sci 2009, 34(1):SP111-SP119.
37. Behrman H.R., Kodaman P.H., Preston S.L., Gao S. Oxidative stress and the ovary. J Soc Gynecol Invest 2001, 8:S40-S42.
38. Agarwal A., Gupta S., Sharma R.K. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005, 3:28.
39. Kasahara E., Sato E.F., Miyoshi M., Konaka R., Hiramoto K., Sasaki J., et al. Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate. Biochem J 2002, 365:849-856.
40. Duchen M.R. Mitochondria in health and disease: perspectives on a new mitochondrial biology. Mol Aspects Med 2004, 25:365-451.
41. Agarwal A., Saleh R.A., Bedaiwy M.A. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril 2003, 79:829-843.