In utero exposure of female CD-1 mice to AZT and/or 3TC: II. Persistence of functional alterations in cardiac tissue

Cardiovascular Toxicology

Volumn 10, Issue 2, 2010, Pages 87-99

  Torres, Salina M ^a,b   Divi, Rao L ^c   Walker, Dale M ^d   McCash, Consuelo L ^b   Carter, Meghan M ^b   Campen, Matthew J ^b   Einem, Tracey L ^c   Chu, Yvonne ^c   Seilkop, Steven K ^d   Kang, Huining ^e   Poirier, Miriam C ^c   Walker, Vernon E ^a,b,f,g  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d SKS Consulting Services   (United States)

^e UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^f BioMosaics Incorporated   (United States)

^g UNIVERSITY OF VERMONT   (United States)

Author keywords

3TC; AZT; Cardiotoxicity; Echocardiography; Mitochondrial DNA content; Mitochondrial DNA mutation; Mitochondrial dysfunction; Mitochondrial toxicity; OXPHOS; Transplacental exposure

Indexed keywords

CYTOCHROME C OXIDASE; LAMIVUDINE; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; MULTIENZYME COMPLEX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CELL FUNCTION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA CONTENT; ENZYME ACTIVITY; FEMALE; GENE MUTATION; GESTATIONAL AGE; HEART MITOCHONDRION; HEART MUSCLE CELL; MONOTHERAPY; MOUSE; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PUERPERIUM; TRANSTHORACIC ECHOCARDIOGRAPHY; ANIMAL; CHEMICALLY INDUCED; DRUG COMBINATION; DRUG EFFECTS; DRUG INTERACTION; ECHOCARDIOGRAPHY; ENVIRONMENTAL EXPOSURE; ENZYMOLOGY; FETOMATERNAL TRANSFUSION; GROWTH, DEVELOPMENT AND AGING; HEART; HEART MUSCLE; INBRED MOUSE STRAIN; LUMINESCENCE; METABOLISM; OXIDATIVE PHOSPHORYLATION; PATHOLOGY; PATHOPHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREGNANCY; PRENATAL EXPOSURE; PROCEDURES; TIME; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; ANTI-HIV AGENTS; CHEMILUMINESCENT MEASUREMENTS; DNA, MITOCHONDRIAL; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; ECHOCARDIOGRAPHY; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HEART; LAMIVUDINE; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; MICE; MICE, INBRED STRAINS; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA, HEART; MYOCARDIUM; OXIDATIVE PHOSPHORYLATION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; TIME FACTORS; ZIDOVUDINE; LUMINESCENT MEASUREMENTS;

MUS;

EID: 77956394304     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12012-010-9065-z     Document Type: Article

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