Absence of cardiac toxicity of zidovudine in infants

New England Journal of Medicine

Volumn 343, Issue 11, 2000, Pages 759-766

  Lipshultz, Steven E ^a,b,c,d,e   Easley, Kirk A ^f   Orav, E John ^g   Kaplan, Samuel ^h   Starc, Thomas J ⁱ   Bricker, J Timothy ^j   Lai, Wyman W ^k   Moodie, Douglas S ^f   Sopko, George ^l   McIntosh, Kenneth ^c,d   Colan, Steven D ^c,d  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f LERNER RESEARCH INSTITUTE   (United States)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h UCLA MEDICAL CENTER   (United States)

ⁱ Columbia University School of Medicine ^*  (United States)

^j BAYLOR COLLEGE OF MEDICINE   (United States)

^k MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^l NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

ZIDOVUDINE;

ARTICLE; CARDIOTOXICITY; DRUG EFFECT; ECHOCARDIOGRAPHY; HEART LEFT VENTRICLE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT DISEASE; MAJOR CLINICAL STUDY; PERINATAL DRUG EXPOSURE; PRIORITY JOURNAL;

ANTI-HIV AGENTS; CHILD, PRESCHOOL; FEMALE; HEART VENTRICLES; HIV INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; LONGITUDINAL STUDIES; MALE; MITOCHONDRIA, HEART; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PRENATAL CARE; PRENATAL EXPOSURE DELAYED EFFECTS; VENTRICULAR FUNCTION, LEFT; ZIDOVUDINE;

EID: 0034648743     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200009143431102     Document Type: Article

References (23)

1. The mitochondrial (mt) genotoxicity of transplacental exposure to 3'-azido-2',3'-dideoxythymidine (AZT) in fetal skeletal and cardiac muscle in paras monkeys
2. Transplacental exposure to 3'-azido-2',3'-dideoxythymidine (AZT) is genotoxic to fetal skeletal and cardiac muscle mitochondria
3. Fetal mitochondrial dys-function in Erthyrocebus Paras monkeys exposed in utero to zidovudine
4. Mitochondrial toxicity of antiviral nucleosides used in AIDS: Insights derived from toxic changes observed in tissues rich in mitochondria
5. In vivo tissue disposition of 3'-azido-3'-deoxythymidine and its anabolites in control and retrovirus-infected mice
6. Transplacental pharmacokinetics and fetal distribution of azidothymidine, its glucuronide, and phosphorylated metabolites in late-term rhesus macaques after maternal infusion
7. Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues
8. Specific mitochondrial DNA deletions in idiopathic dilated cardiomyopathy
9. Mitochondrial function in children with idiopathic dilated cardiomyopathy
10. Effect of zidovudine and didanosine treatment on heart function in children infected with human immunodeficiency virus
11. Cardiac structure and function in children with human immunodeficiency virus infection treated with zidovudine
12. Cardiovascular involvement in children with HIV infection
13. Zidovudine therapy and left ventricular function and mass in human immunodeficiency virus-infected patients
14. Fetal cardiorespiratory and neurobehavioral response to zidovudine (AZT) in the baboon
15. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment
16. Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women
17. Clinical approach to genetic cardiomyopathy in children
18. Limitations of fractional shortening as an index of contractility in pediatric patients infected with human immunodeficiency virus
19. 2 HIV Multicenter Study
20. Cardiac complications in children with human immunodeficiency virus infection
21. 2 HIV Multicenter Study
22. 2 HIV) infection study: Design and methods
23. HIV nucleoside analogues: New adverse effects on mitochondria?