Persistence of mitochondrial toxicity in hearts of female B6C3F1 mice exposed in uteroto 3′-azido-3′-deoxythymidine

Cardiovascular Toxicology

Volumn 4, Issue 2, 2004, Pages 133-153

  Walker, Dale M ^a   Poirier, Miriam C ^b   Campen, Matthew J ^a   Cook Jr , Dennis L ^a   Divi, Rao L ^b   Nagashima, Kynio ^c   Lund, Amie K ^d   Cossey, Patsy Y ^a   Hahn, Fletcher F ^a   Walker, Vernon E ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

^d UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

3TC; AZT; Cardiomyopathy; DGGE; Mitochondria; Mitochondrial DNA mutations

Indexed keywords

BIOLOGICAL MARKER; CYTOCHROME C OXIDASE; DRUG METABOLITE; LAMIVUDINE; MITOCHONDRIAL DNA; RNA DIRECTED DNA POLYMERASE INHIBITOR; THYMIDINE KINASE; TRANSFER RNA; ZIDOVUDINE; ZIDOVUDINE 5' PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMEGALY; CARDIOTOXICITY; CONTROLLED STUDY; DOSE RESPONSE; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; FEMALE; GENE MUTATION; HEART DISEASE; HEART FUNCTION; HEART MITOCHONDRION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MITOCHONDRIAL TOXICITY; MOUSE; MUSCLE FIBRIL; NEWBORN; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; ULTRASTRUCTURE;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTI-HIV AGENTS; BODY WEIGHT; CARDIOMYOPATHIES; DNA, MITOCHONDRIAL; DRUG INTERACTIONS; ELECTROCARDIOGRAPHY; ELECTRON TRANSPORT COMPLEX IV; FEMALE; LAMIVUDINE; MALE; MATERNAL-FETAL EXCHANGE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MUTATION; MYOCARDIUM; ORGAN SIZE; PILOT PROJECTS; PREGNANCY; SEX FACTORS; ZIDOVUDINE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 4744374408     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1385/CT:4:2:133     Document Type: Article

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