Neuroimaging genetics: New perspectives in research on major depression?

Acta Psychiatrica Scandinavica

Volumn 118, Issue 5, 2008, Pages 363-372

  Frodl, T ^a   Moller H J ^a   Meisenzahl, E ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Hippocampus; Major depression; Neuroimaging genetics; Neuroplasticity; Psychiatry

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER;

ALLELE; AMYGDALOID NUCLEUS; BRAIN SIZE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HIPPOCAMPUS; HOMOZYGOSITY; HUMAN; MAJOR DEPRESSION; NEUROIMAGING; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR BINDING; REVIEW;

ALLELES; AMYGDALA; AROUSAL; ATROPHY; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSIVE DISORDER, MAJOR; EMOTIONS; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE DETECTION; HIPPOCAMPUS; HOMOZYGOTE; HUMANS; MAGNETIC RESONANCE IMAGING; OXYGEN; POLYMORPHISM, GENETIC; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL;

EID: 53749101144     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/j.1600-0447.2008.01225.x     Document Type: Review

References (82)

1. Ustun TB, Cooper JE, Van Duuren-Kristen S, Kennedy C, Hendershot G, Sartorius N. Revision of the ICIDH: mental health aspects. WHO/MNH Disability Working Group. Disabil Rehabil 1995 17 : 202 209.
2. Murray CJ, Lopez AD. Global and regional descriptive epidemiology of disability: incidence, prevalence, healthy expectancies and years lived with disability. In : Murray CJ, Lopez AD, eds. The global burden of disease. Global burden of disease and injury series, Vol. I. Cambridge, MA : Harvard University Press, 1997 : 201 246.
3. Duman RS. Pathophysiology of depression: the concept of synaptic plasticity. Eur Psychiatry 2002 17 (suppl. 3 306 310.
4. Woolley CS, Gould E, Mcewen BS. Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons. Brain Res 1990 531 : 225 231.
5. Reagan LP, Mcewen BS. Controversies surrounding glucocorticoid-mediated cell death in the hippocampus. J Chem Neuroanat 1997 13 : 149 167.
6. Santarelli L, Saxe M, Gross C et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003 301 : 805 809.
7. Lu B, Gottschalk W. Modulation of hippocampal synaptic transmission and plasticity by neurotrophins. Prog Brain Res 2000 128 : 231 241.
8. Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 1995 15 : 7539 7547.
9. Berton O, Mcclung CA, Dileone RJ et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 2006 311 : 864 868.
10. Axelson DA, Doraiswamy PM, Mcdonald WM et al. Hypercortisolemia and hippocampal changes in depression. Psychiatry Res 1993 47 : 163 173.
11. Coffey CE, Wilkinson WE, Weiner RD et al. Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Arch Gen Psychiatry 1993 50 : 7 16.
12. Pantel J, Schroder J, Essig M et al. Quantitative magnetic resonance imaging in geriatric depression and primary degenerative dementia. J Affect Disord 1997 42 : 69 83.
13. Ashtari M, Greenwald BS, Kramer-Ginsberg E et al. Hippocampal/amygdala volumes in geriatric depression. Psychol Med 1999 29 : 629 638.
14. Posener JA, Wang L, Price JL et al. High-dimensional mapping of the hippocampus in depression. Am J Psychiatry 2003 160 : 83 89.
15. Caetano SC, Hatch JP, Brambilla P et al. Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression. Psychiatry Res 2004 132 : 141 147.
16. Vythilingam M, Vermetten E, Anderson GM et al. Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biol Psychiatry 2004 56 : 101 112.
17. Hastings RS, Parsey RV, Oquendo MA, Arango V, Mann JJ. Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression. Neuropsychopharmacology 2004 29 : 952 959.
18. Sheline YI, Sanghavi M, Mintun MA, Gado MH. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 1999 19 : 5034 5043.
19. Mervaala E, Fohr J, Kononen M et al. Quantitative MRI of the hippocampus and amygdala in severe depression. Psychol Med 2000 30 : 117 125.
20. Steffens DC, Byrum CE, Mcquoid DR et al. Hippocampal volume in geriatric depression. Biol Psychiatry 2000 48 : 301 309.
21. Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS. Hippocampal volume reduction in major depression. Am J Psychiatry 2000 157 : 115 118.
22. Janssen J, Hulshoff Pol HE, Lampe IK et al. Hippocampal changes and white matter lesions in early-onset depression. Biol Psychiatry 2004 56 : 825 831.
23. Frodl T, Schaub A, Banac S et al. Reduced hippocampal volume correlates with executive dysfunctioning in major depression. J Psychiatry Neurosci 2006 31 : 316 323.
24. Neumeister A, Wood S, Bonne O et al. Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects. Biol Psychiatry 2005 57 : 935 937.
25. Saylam C, Ucerler H, Kitis O, Ozand E, Gonul AS. Reduced hippocampal volume in drug-free depressed patients. Surg Radiol Anat 2006 28 : 82 87.
26. Campbell S, Marriott M, Nahmias C, Macqueen GM. Lower hippocampal volume in patients suffering from depression: a meta-analysis. Am J Psychiatry 2004 161 : 598 607.
27. Videbech P, Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 2004 161 : 1957 1966.
28. Sheline YI, Gado MH, Kraemer HC. Untreated depression and hippocampal volume loss. Am J Psychiatry 2003 160 : 1516 1518.
29. Frodl T, Meisenzahl E, Zetzsche T et al. Enlargement of the amygdala in patients with a first episode of major depression. Biol Psychiatry 2002 51 : 708 714.
30. Lange C, Irle E. Enlarged amygdala volume and reduced hippocampal volume in young women with major depression. Psychol Med 2004 34 : 1059 1064.
31. Frodl T, Meisenzahl EM, Zetzsche T et al. Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects. Biol Psychiatry 2003 53 : 338 344.
32. Sheline YI, Gado MH, Price JL. Amygdala core nuclei volumes are decreased in recurrent major depression. Neuroreport 1998 9 : 2023 2028.
33. Ballmaier M, Toga AW, Blanton RE et al. Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. Am J Psychiatry 2004 161 : 99 108.
34. Caetano SC, Kaur S, Brambilla P et al. Smaller cingulate volumes in unipolar depressed patients. Biol Psychiatry 2006 59 : 702 706.
35. Botteron KN, Raichle ME, Drevets WC, Heath AC, Todd RD. Volumetric reduction in left subgenual prefrontal cortex in early onset depression. Biol Psychiatry 2002 51 : 342 344.
36. Drevets WC, Price JL, Simpson JR, Jr et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997 386 : 824 827.
37. Bremner JD, Vythilingam M, Vermetten E et al. Reduced volume of orbitofrontal cortex in major depression. Biol Psychiatry 2002 51 : 273 279.
38. Husain MM, Mcdonald WM, Doraiswamy PM et al. A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Res 1991 40 : 95 99.
39. Krishnan KR, Mcdonald WM, Escalona PR et al. Magnetic resonance imaging of the caudate nuclei in depression. Preliminary observations. Arch Gen Psychiatry 1992 49 : 553 557.
40. Pompili M, Ehrlich S, De PE et al. White matter hyperintensities and their associations with suicidality in patients with major affective disorders. Eur Arch Psychiatry Clin Neurosci 2007 257 : 494 499.
41. Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ, Mintun MA. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol Psychiatry 2001 50 : 651 658.
42. Surguladze S, Brammer MJ, Keedwell P et al. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biol Psychiatry 2005 57 : 201 209.
43. Fu CH, Williams SC, Cleare AJ et al. Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry 2004 61 : 877 889.
44. Anand A, Li Y, Wang Y et al. Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry 2005 57 : 1079 1088.
45. Wagner G, Sinsel E, Sobanski T et al. Cortical inefficiency in patients with unipolar depression: an event-related FMRI study with the Stroop task. Biol Psychiatry 2006 59 : 958 965.
46. Rose EJ, Simonotto E, Ebmeier KP. Limbic over-activity in depression during preserved performance on the n-back task. Neuroimage 2006 29 : 203 215.
47. Fu CH, Williams SC, Cleare AJ et al. Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry 2004 61 : 877 889.
48. Schatzberg AF. Brain imaging in affective disorders: more questions about causes versus effects. Am J Psychiatry 2002 159 : 1807 1808.
49. Frodl T, Meisenzahl EM, Zetzsche T et al. Hippocampal changes in patients with a first episode of major depression. Am J Psychiatry 2002 159 : 1112 1118.
50. Bartley AJ, Jones DW, Weinberger DR. Genetic variability of human brain size and cortical gyral patterns. Brain 1997 120 (Pt 2 257 269.
51. Rujescu D, Meisenzahl EM, Giegling I et al. Methionine homozygosity at codon 129 in the prion protein is associated with white matter reduction and enlargement of CSF compartments in healthy volunteers and schizophrenic patients. Neuroimage 2002 15 : 200 206.
52. Meisenzahl EM, Rujescu D, Kirner A et al. Association of an interleukin-1beta genetic polymorphism with altered brain structure in patients with schizophrenia. Am J Psychiatry 2001 158 : 1316 1319.
53. Aston C, Jiang L, Sokolov BP. Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Mol Psychiatry 2005 10 : 309 322.
54. Gilad GM, Gilad VH. Stress-induced dynamic changes in mouse brain polyamines. Role in behavioral reactivity. Brain Res 2002 943 : 23 29.
55. Sequeira A, Gwadry FG, Ffrench-Mullen JM et al. Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry 2006 63 : 35 48.
56. Hariri AR, Drabant EM, Weinberger DR. Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biol Psychiatry 2006 59 : 888 897.
57. Meyer-Lindenberg A, Weinberger DR. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 2006 7 : 818 827.
58. Kim DH, Payne ME, Levy RM, Macfall JR, Steffens DC. APOE genotype and hippocampal volume change in geriatric depression. Biol Psychiatry 2002 51 : 426 429.
59. Steffens DC, Potter GG, Mcquoid DR et al. Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study. Am J Geriatr Psychiatry 2007 15 : 839 849.
60. Frodl T, Meisenzahl EM, Zill P et al. Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression. Arch Gen Psychiatry 2004 61 : 177 183.
61. Taylor WD, Steffens DC, Payne ME et al. Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. Arch Gen Psychiatry 2005 62 : 537 544.
62. Hickie IB, Naismith SL, Ward PB et al. Serotonin transporter gene status predicts caudate nucleus but not amygdala or hippocampal volumes in older persons with major depression. J Affect Disord 2007 98 : 137 142.
63. Egan MF, Kojima M, Callicott JH et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003 112 : 257 269.
64. Hariri AR, Goldberg TE, Mattay VS et al. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 2003 23 : 6690 6694.
65. Pezawas L, Verchinski BA, Mattay VS et al. The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 2004 24 : 10099 10102.
66. Nemoto K, Ohnishi T, Mori T et al. The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology. Neurosci Lett 2006 397 : 25 29.
67. Vollmayr B, Keck S, Henn FA, Schloss P. Acute stress decreases serotonin transporter mRNA in the raphe pontis but not in other raphe nuclei of the rat. Neurosci Lett 2000 290 : 109 112.
68. Frodl T, Schule C, Schmitt G et al. Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry 2007 64 : 410 416.
69. Taylor WD, Zuchner S, Mcquoid DR et al. The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression. Am J Geriatr Psychiatry 2008 16 : 263 271.
70. Kamiya A, Kubo K, Tomoda T et al. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat Cell Biol 2005 7 : 1167 1178.
71. Millar JK, Pickard BS, Mackie S et al. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 2005 310 : 1187 1191.
72. Sawamura N, Sawamura-Yamamoto T, Ozeki Y, Ross CA, Sawa A. A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proc Natl Acad Sci U S A 2005 102 : 1187 1192.
73. Hashimoto R, Numakawa T, Ohnishi T et al. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet 2006 15 : 3024 3033.
74. Hariri AR, Drabant EM, Munoz KE et al. A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 2005 62 : 146 152.
75. Heinz A, Braus DF, Smolka MN et al. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 2005 8 : 20 21.
76. Dannlowski U, Ohrmann P, Bauer J et al. 5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression. Neuropsychopharmacology 2008 33 : 418 424.
77. Dannlowski U, Ohrmann P, Bauer J et al. Serotonergic genes modulate amygdala activity in major depression. Genes Brain Behav 2007 6 : 672 676.
78. Ekman P, Friesen WV. Pictures of facial affect. Palo Alto, CA : Consulting Psychologists Press, 1976.
79. Parsey RV, Hastings RS, Oquendo MA et al. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry 2006 163 : 48 51.
80. Caspi A, Sugden K, Moffitt TE et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003 301 : 386 389.
81. Frodl T, Meisenzahl EM, Zetzsche T et al. Hippocampal and amygdala changes in patients with major depressive disorder and healthy controls during a 1-year follow-up. J Clin Psychiatry 2004 65 : 492 499.
82. Hariri AR, Mattay VS, Tessitore A et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002 297 : 400 403.