Facilitation of acetylcholine release in rat frontal cortex by indeloxazine hydrochloride: Involvement of endogenous serotonin and 5-HT4 receptors

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 6, 1997, Pages 712-720

  Yamaguchi, Takashi ^a   Suzuki, Masanori ^a   Yamamoto, Minoru ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

5 HT4 receptor; Acetylcholine; Frontal cortex; Indeloxazine; Serotonin

Indexed keywords

4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 3 PIPERIDINOPROPYL ESTER; ACETYLCHOLINE; CITALOPRAM; INDELOXAZINE; MAPROTILINE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; NORADRENALIN; ONDANSETRON; RITANSERIN; SEROTONIN;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; AROUSAL; ARTICLE; CHOLINERGIC SYSTEM; COGNITION; CONTROLLED STUDY; FACILITATION; FRONTAL CORTEX; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NONHUMAN; RAT;

EID: 0030867059     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005110     Document Type: Article

References (50)

1. 1Dβ receptor. Mol Pharmacol 41:1-7
2. Barlus RT, Dean RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-416
3. Batsche K, Ashby CR, Lee C, Schwartz J, Wang RY (1994) The behavioral effects of the stereoisomers of 4-methylaminorex, a psychostimulant, in the rat. J Pharmacol Exp Ther 269:1029-1039
4. Blier P, de Montigny C (1994) Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15:220-226
5. Boddeke HW, Kalkman HO (1990) Zacopride and BRL 24924 induce an increase in EEG-energy in rats. Br J Pharmacol 101: 281-284
6. Cassel JC, Jeltsch H (1995) Serotonergic modulation of cholinergic function in the central nervous system:cognitive implications. Neuroscience 69:1-41
7. 4 receptor stimulation facilitates acetylcholine release in rat frontal cortex. Neuroreport 5:1230-1232
8. 3 receptors. J Neurochem 62:2254-2261
9. 1B receptors. J Pharmacol Exp Ther 277:823-830
10. Day J, Fibiger HC (1993) Dopaminergic regulation of cortical acetylcholine release: effects of dopamine receptor agonists. Neuroscience 54:643-648
11. Day JC, Tham CS, Fibiger HC (1994) Dopamine depletion attenuates amphetamine-induced increases of cortical acetylcholine release. Eur J Pharmacol 263:285-292
12. Decker MW, McGaugh JL (1991) The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 7:151-168
13. Descarries L, Lemay B, Doucet G, Berger B (1987) Regional and laminar density of the dopamine innervation in adult rat cerebral cortex. Neuroscience 21:807-824
14. 2 dopamine receptors. Neuroscience 19:125-137
15. 4 receptors. Trends Pharmacol Sci 16:391-397
16. Fibiger HC (1991) Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence. Trends Neurosci 14:220-223
17. Fuller RW (1994) Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci 55:163-167
18. Fuxe K, Hamberger B, Hökfelt T (1968) Distribution of noradrenaline nerve terminals in cortical areas of the rat. Brain Res 8: 125-131
19. Goffinet AM, de Voider A (1985) Autoradiographic analysis of adrenergic receptors in the mammalian brain. Acta Neurol Belg 85:82-109
20. Harada M, Maeno H (1979) Biochemical characteristics of a potential antidepressant, 2-(7-indenyloxymethy)morpholine hydrochloride (YM-08054-1). Biochem Pharmacol 28:2645-2651
21. Hirano H, Day J, Fibiger HC (1995) Serotonergic regulation of acetylcholine release in rat frontal cortex. J Neurochem 65: 1139-1145
22. Itoh Y, Ogasawara T, Mushiroi T, Yamazaki A, Ukai Y, Kimura K (1994) Effect of NS-3, a thyrotropin-releasing hormone analog, on in vivo acetylcholine release in rat brain: regional differences and its sites of action. J Pharmacol Exp Ther 271:884-890
23. Kihara T, Ikeda M (1995) Effects of duloxetine, a new serotonin and norepinephrine uptake inhibitor, on extracellular monoamine levels in rat frontal cortex. J Pharmacol Exp Ther 272: 177-183
24. Lehmann J, Nagy JI, Atmadja S, Fibiger HC (1980) The nucleus basalis magnocellularis: the origin of a cholinergic projection to the neocortex of the rat. Neuroscience 5:1161-1174
25. 1A receptors in vivo. Eur J Pharmacol 24:307-310
26. Lidov HG, Grzanna R, Molliver ME (1980) The serotonin innervation of the cerebral cortex in the rat - an immunohistochemical analysis. Neuroscience 5:207-227
27. Martin GR, Humphrey PPA (1994) Receptors for 5-hydroxytryptamine: current perspectives on classification and nomenclature. Neuropharmacology 33:261-273
28. Matsumoto M, Yoshioka M, Togashi H, Tochihara M, Ikeda T, Saito H (1995) Modulation of norepinephrine release by serotonergic receptors in the rat hippocampus as measured by in vivo microdialysis. J Pharmacol Exp Ther 272:1044-1051
29. Monsma FJ Jr, Shen Y, Ward RP, Hamblin MW, Sibley DR (1993) Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol 43:320-327
30. Nilsson OG, Strecker RE, Daszuta A, Björklund A (1988) Combined cholinergic and serotonergic denervalion of the forebrain produces severe deficits in a spatial learning task in the rat. Brain Res 453:235-246
31. Ohue T, Koshimura K, Takagi Y, Watanabe Y, Miwa S, Masaki T (1993) Enhancement of acetylcholine release in the hippocampus by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin is mediated by 5-hydroxytryptamine. Brain Res 607:255-260
32. Ozawa Y, Ohyama M, Suzuki M, Yamaguchi T, Miyata K, Terai M, Yamamoto M (1994) Pharmacological actions of indeloxazine hydrochloride, a cerebral activator, in forced swimming and passive avoidance tests of senescence-accelerated mouse. Jpn J Pharmacol 61:[Suppl] 358
33. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic Press, New York
34. 1C receptors. J Pharmacol Exp Ther 260:1361-1365
35. 4 recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology 33:543-549
36. Semba K, Reiner PB, McGeer EG, Fibiger HC (1988) Brainstem afferents to the magnocellular basal forebrain studied by axonal transport, immunohistochemistry, and electrophysiology in the rat. J Comp Neurol 267:433-453
37. 7 serotonin receptor subtype. J Biol Chem 268:18 200-18 204
38. Shimizu-Sasamata M, Yamamoto M, Okada M, Yamaguchi T, Tamura A (1991) Effects of indeloxazine hydrochloride on behavioral and biochemical changes in the chronic phase of focal cerebral ischemia in rats. Arch Int Pharmacodyn 314:74-89
39. 3H]choline from slices of guinea pig nucleus basalis magnocellularis. Naunyn-Schmiedeberg's Arch Pharmacol 350:10-14
40. Steckler T, Sahgal A (1995) The role of serotonergic-cholinergic interactions in the mediation of cognitive behaviour. Behav Brain Res 67:165-199
41. Terai T, Kuroiwa I (1985) Effects of indeloxazine hydrochloride on receptor binding. Clin Rep 19:4584-4588
42. 4 receptors and gastrointestinal prokinetic action. Pharmacol Res 24:5-14
43. Vanderwolf CH (1987) Near-total loss of 'learning' and 'memory' as a result of combined cholinergic and serotonergic blockade in the rat. Behav Brain Res 23:43-57
44. Yamaguchi T, Ozawa Y, Suzuki M, Yamamoto M, Nakamura T, Yamaura A (1996) Indeloxazine hydrochloride improves impairment of passive avoidance performance after fluid percussion brain injury in rats. Neuropharmacology 35:329-336
45. 4 receptor involvement in the enhancement of acetylcholine release by p-chloroamphetamine in rat frontal cortex. Brain Res (in press)
46. Yamamoto M (1990) Pharmacological and biochemical properties of indeloxazine hydrochloride, a new cerebral activator. Brain Dysfunct 3:130-147
47. Yamamoto M, Shimizu M (1988) Electroencephalographic studies on a new cerebral activator, indeloxazine hydrochloride. Curr Ther Res 43:92-105
48. Yamamoto M, Takahashi K, Yamaguchi T, Takeuchi H, Yatsugi S, Kogure K (1992) Effects of indeloxazine hydrochloride, a new cerebral activator, on passive avoidance response in gerbils subjected to repeated cerebral ischemia by carotid artery occlusion. Res Commun Psychol Psychiat Behav 17:123-132
49. Yamamoto M, Ooyama M, Ozawa Y, Okada M, Tada S, Yamaguchi T, Endo H (1993) Effects of indeloxazine hydrochloride, a cerebral activator, on passive avoidance learning impaired by disruption of cholinergic transmission in rats. Neuropharmacology 32:695-701
50. Zilles K, Werner L, Qü M, Schleicher A, Gross G (1991) Quantitative autoradiography of 11 different transmitter binding sites in the basal forebrain region of the rat - evidence of heterogeneity in distribution patterns. Neuroscience 42:473-481