MVL-PLA2, a snake venom phospholipase A2, inhibits angiogenesis through an increase in microtubule dynamics and disorganization of focal adhesions

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Bazaa, Amine ^a   Pasquier, Eddy ^b   Defilles, Céline ^b   Limam, Ines ^a   Kessentini Zouari, Raoudha ^a   Kallech Ziri, Olfa ^a   Battari, Assou El ^b   Braguer, Diane ^b   Ayeb, Mohamed El ^a   Marrakchi, Naziha ^a,c   Luis, José ^b  

^a PASTEUR INSTITUTE OF TUNIS   (Tunisia)

^b AIX MARSEILLE UNIVERSITY   (France)

^c UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ARGINYLGLYCYLASPARTIC ACID; INTEGRIN; MATRIGEL; MVL PLA2; PACLITAXEL; PHOSPHOLIPASE A2; SNAKE VENOM; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; ANGIOGENESIS INHIBITOR;

ACTIN FILAMENT; ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL ADHESION; CELL MIGRATION; CHORIOALLANTOIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENDOTHELIUM CELL; FOCAL ADHESION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROTUBULE; VASCULAR ENDOTHELIUM; ANIMAL; CELL CULTURE; CELL MOTION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; METABOLISM;

MACROVIPERA LEBETINA;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FOCAL ADHESIONS; HUMANS; MICROTUBULES; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHOLIPASES A2; SNAKE VENOMS;

EID: 77956303573     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010124     Document Type: Article

References (45)

1. Folkman J (1972) Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg 175: 409-416.
2. Garmy-Susini B, Varner JA (2008) Roles of integrins in tumor angiogenesis and lymphangiogenesis. Lymphat Res Biol 6: 155-163.
3. Akalu A, Cretu A, Brooks PC (2005) Targeting integrins for the control of tumour angiogenesis. Expert Opin Investig Drugs 14: 1475-1486.
4. Humphries MJ (2000) Integrin structure. Biochem Soc Trans 28: 311-339.
5. Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687.
6. Alghisi GC, Ruegg C (2006) Vascular integrins in tumor angiogenesis: mediators and therapeutic targets. Endothelium 13: 113-135.
7. Burridge K, Fath K, Kelly T, Nuckolls G, Turner C (1988) Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu Rev Cell Biol 4: 487-525.
8. Wehrle-Haller B, Imhof BA (2003) Actin, microtubules and focal adhesion dynamics during cell migration. Int J Biochem Cell Biol 35: 39-50.
9. Rodriguez OC, Schaefer AW, Mandato CA, Forscher P, Bement WM, et al. (2003) Conserved microtubule-actin interactions in cell movement and morphogenesis. Nat Cell Biol 5: 599-609.
10. Wu X, Kodama A, Fuchs E (2008) ACF7 Regulates Cytoskeletal-Focal Adhesion Dynamics and Migration and Has ATPase Activity. Cell 135: 137-148.
11. Small JV, Kaverina I (2003) Microtubules meet substrate adhesions to arrange cell polarity. Curr Opin Cell Biol 15: 40-47.
12. Andrews RK, Berndt MC (2000) Snake venom modulators of platelet adhesion receptors and their ligands. Toxicon 38: 775-791.
13. Olfa KZ, Jose L, Salma D, Amine B, Najet SA, et al. (2005) Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis. Lab Invest 85: 1507-1516.
14. Calvete JJ, Marcinkiewicz C, Sanz L (2007) KTS and RTS-disintegrins: antiangiogenic viper venom peptides specifically targeting the alpha 1 beta 1 integrin. Curr Pharm Des 13: 2853-2859.
15. McLane MA, Joerger T, Mahmoud A (2008) Disintegrins in health and disease. Front Biosci 13: 6617-6637.
16. Pilorget A, Conesa M, Sarray S, Michaud-Levesque J, Daoud S, et al. (2007) Lebectin, a Macrovipera lebetina venom-derived C-type lectin, inhibits angiogenesis both in vitro and in vivo. J Cell Physiol 211: 307-315.
17. Sarray S, Berthet V, Calvete JJ, Secchi J, Marvaldi J, et al. (2004) Lebectin, a novel C-type lectin from Macrovipera lebetina venom, inhibits integrinmediated adhesion, migration and invasion of human tumour cells. Laboratory Investigation 84: 573-581.
18. Sarray S, Delamarre E, Marvaldi J, El Ayeb M, Marrakchi N, et al. (2007) Lebectin and lebecetin, two C-type lectins from snake venom, inhibit a5b1 and av-containing integrins. Matrix Biol 26: 306-313.
19. Kini RM (2003) Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes. Toxicon 42: 827-840.
20. Bazaa A, Luis J, Srairi-Abid N, Kallech-Ziri O, Kessentini-Zouari R, et al. (2009) MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration. Matrix Biol 28: 188-193.
21. Zouari-Kessentini R, Luis J, Karray A, Kallech-Ziri O, Srairi-Abid N, et al. (2009) Two purified and characterized phospholipases A2 from Cerastes cerastes venom, that inhibit cancerous cell adhesion and migration. Toxicon 53: 444-453.
22. Pourroy B, Honore S, Pasquier E, Bourgarel-Rey V, Kruczynski A, et al. (2006) Antiangiogenic concentrations of vinflunine increase the interphase microtubule dynamics and decrease the motility of endothelial cells. Cancer Res 66: 3256-3263.
23. Delamarre E, Taboubi S, Mathieu S, Berenguer C, Rigot V, et al. (2009) Expression of integrin alpha6beta1 enhances tumorigenesis in glioma cells. Am J Pathol 175: 844-855.
24. Pasquier E, Carre M, Pourroy B, Camoin L, Rebai O, et al. (2004) Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway. Mol Cancer Ther 3: 1301-1310.
25. Pasquier E, Honore S, Pourroy B, Jordan MA, Lehmann M, et al. (2005) Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells. Cancer Res 65: 2433-2440.
26. Serini G, Valdembri D, Bussolino F (2006) Integrins and angiogenesis: a sticky business. Exp Cell Res 312: 651-658.
27. Hodivala-Dilke K (2008) alphavbeta3 integrin and angiogenesis: a moody integrin in a changing environment. Curr Opin Cell Biol 20: 514-519.
28. Gardel ML, Sabass B, Ji L, Danuser G, Schwarz US, et al. (2008) Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. J cell Biol 183: 999-1005.
29. Honore ́ S, Pasquier E, Braguer D (2005) Understanding microtubule dynamics for improved cancer therapy. Cell Mol Life Sci 62: 3039-3056.
30. Pasquier E, Honore ́ S, Braguer D (2006) Microtubule-targeting agents in angiogenesis: where do we stand? Drug Resist Updat 9: 74-86.
31. Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186.
32. Folkman J (2007) Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6: 273-286.
33. Drake CJ, Cheresh DA, Little CD (1995) An antagonist of integrin alpha v beta 3 prevents maturation of blood vessels during embryonic neovascularization. J Cell Sci 108 (Pt 7): 2655-2661.
34. Stupack DG, Cheresh DA (2004) Integrins and angiogenesis. Curr Top Dev Biol 64: 207-238.
35. Kim SY, Oh HK, Ha JM, Ahn HY, Shin JC, et al. (2007) RGD-peptide presents anti-adhesive effect, but not direct pro-apoptotic effect on endothelial progenitor cells. Arch Biochem Biophys 459: 40-49.
36. Sheu JR, Yen MH, Kan YC, Hung WC, Chang PT, et al. (1997) Inhibition of angiogenesis in vitro and in vivo: comparison of the relative activities of triflavin, an Arg-Gly-Asp-containing peptide and anti-alpha(v)beta3 integrin monoclonal antibody. Biochim Biophys Acta 1336: 445-454.
37. Lauffenburger DA, Horwitz AF (1996) Cell migration: a physically integrated molecular process. Cell 84: 359-369.
38. Castel S, Pagan R, Garcia R, Casaroli-Marano RP, Reina M, et al. (2000) Alpha v integrin antagonists induce the disassembly of focal contacts in melanoma cells. Eur J Cell Biol 79: 502-512.
39. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, et al. (2003) Cell migration: integrating signals from front to back. Science 302: 1704-1709.
40. Pasquier E, Andre N, Braguer D (2007) Targeting microtubules to inhibit angiogenesis and disrupt tumour vasculature: implications for cancer treatment. Curr Cancer Drug Targets 7: 566-581.
41. Honore ́ S, Pagano A, Gauthier G, Bourgarel-Rey V, Verdier-Pinard P, et al. (2008) Antiangiogenic vinflunine affects EB1 localization and microtubule targeting to adhesion sites. Mol Cancer Ther 7: 2080-2089.
42. Zaoui K, Honore S, Isnardon D, Braguer D, Badache A (2008) Memo-RhoAmDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells. J Cell Biol 183: 401-408.
43. Pletjushkina OJ, Ivanova OJ, Kaverina IN, Vasiliev JM (1994) Taxol-treated fibroblasts acquire an epithelioid shape and a circular pattern of actin bundles. Exp Cell Res 212: 201-208.
44. Etienne-Manneville S (2004) Actin and microtubules in cell motility: which one is in control? Traffic 5: 470-477.
45. Moissoglu K, Schwartz MA (2006) Integrin signalling in directed cell migration. Biol Cell 98: 547-555.