Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor βtype I receptor

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 26798-26805

  Burch, Micah L ^a,b   Ballinger, Mandy L ^a,c   Yang, Sundy N Y ^a   Getachew, Robel ^a   Itman, Catherine ^b   Loveland, Kate ^b   Osman, Narin ^a,b   Little, Peter J ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL REGIONS; CORE PROTEINS; CYTOSOLIC; EPIDERMAL GROWTH FACTOR RECEPTORS; G PROTEIN; G-PROTEIN COUPLED RECEPTORS; GLYCOSAMINOGLYCANS; GROWTH FACTOR; POTENT ACTIVATORS; PROTEASE ACTIVATED RECEPTORS; PROTEASE-ACTIVATED RECEPTOR-1; PROTEIN TYROSINE KINASE; PROTEOGLYCAN SYNTHESIS; PROTEOGLYCANS; SIGNAL CHANGES; SIGNALING PATHWAYS; THERAPEUTIC TARGETS; TRANSACTIVATION; TRANSFORMING GROWTH FACTORS; VASCULAR SMOOTH MUSCLE CELLS; VASCULAR SMOOTH MUSCLES;

AMINO ACIDS; BIOMIMETICS; BLOOD VESSEL PROSTHESES; ENZYME INHIBITION; GLYCOPROTEINS; MUSCLE; PHOSPHATASES; PHOSPHORYLATION; SIGNALING; TRANSCRIPTION FACTORS;

PEPTIDES;

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ENZYME INHIBITOR; G PROTEIN COUPLED RECEPTOR; JNJ 5177094; PROTEINASE ACTIVATED RECEPTOR 1; PROTEOGLYCAN; SMAD2 PROTEIN; SMAD2C PROTEIN; SMALL INTERFERING RNA; THROMBIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STIMULATION; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEOGLYCAN SYNTHESIS; RECEPTOR UPREGULATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

BENZAMIDES; CELLS, CULTURED; DIOXOLES; HUMANS; LIPOPROTEINS, LDL; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEOGLYCANS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, PAR-1; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; THROMBIN; TRANSCRIPTIONAL ACTIVATION; TRANSFORMING GROWTH FACTOR BETA;

EID: 77956258719     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.092767     Document Type: Article

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