The rhGM-CSF-EPO hybrid protein men 11300 induces anti-EPO antibodies and severe anaemia in rhesus monkeys

Cytokine

Volumn 10, Issue 12, 1998, Pages 964-969

  Coscarella, Annamaria ^a   Liddi, Roberto ^a   Di Loreto, Mario ^a   Bach, Simona ^a   Faiella, Angela ^a   Van Der Meide, Peter H ^b   Mele, Antonio ^a   De Santis, Rita ^a  

^a Menarini Ricerche SpA   (Italy)

^b BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

Author keywords

GM CSF fusion protein; Immunogenicity; Primate model

Indexed keywords

ANTIBODY; AUTOANTIBODY; ERYTHROPOIETIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; MEN 11300; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG;

ANEMIA; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; CLINICAL CHEMISTRY; CONTROLLED STUDY; ERYTHROCYTE COUNT; FEMALE; HEMATOPOIETIC CELL; IMMUNOGENICITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RETICULOCYTE COUNT; RHESUS MONKEY;

ANIMALIA; MACACA MULATTA; PRIMATES;

EID: 0032469128     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1998.0384     Document Type: Article

References (21)

1. 1. Coscarella A, Carloni C, Liddi R, Mauro S, Novelli S, Mele A, Massella B, Valtieri M, De Santis R (1997) Production of recombinant human GM-CSF-EPO hybrid proteins: in vitro biological characterization. Eur J Haematol 59:238-246.
2. 2. Coscarella A, Liddi R, Bach S, Zappitelli S, Urso R, Hele A, De Santis R (1998) Pharmacokinetic and immunogenic behavior of three recombinant human 6H-CSF-EPO hybrid proteins in cynomolcus monkeys. Mol Biotechnol (in press).
3. 3. Hopp TH, Woods K (1981) Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci USA 78:3824-3828.
4. 4. Amoresano A, Andolfo A, Siciliano RA, Mele A, Coscarella A, De Santis R, Mauro S, Pucci P, Marino G (1998) Structural characterization and independent folding of a chimeric glycoprotein comprising Granulocyte-Macrophage Colony Stimulating Factor and Erythropoietin sequences. Glycobiology 8:779-790.
5. 5. George JW, Bracco CA, Shannon KM, Davis J, Smith IL, Phibbs RH, Hendrickx AG (1990) Age-related differences in erythropoietic response to recombinant human erythropoietin: comparison in adult and infant rhesus monkeys. Pediatric Res 28:567-571.
6. 6. Burchiel SW, Oette D, Day PW, Stoll RE (1994) Analysis of radiolabeled CHO cell-derived rhGM-CSF pharmacokinetics and biodistribution in rhesus monkeys following intravenous and subcutaneous injection. Int J Immunopharmacol 16:75-90.
7. 7. Williams DW, Dunn JT, Park LS, Friend EA, Seiler FR, Farese AM, MacVittie TJ (1993) A GM-CSF/IL-3 fusion protein promotes neutrophil and platelet recovery in sublethally irradiated rhesus monkeys. Biotechnol Ther 4(1 & 2): 17-29.
8. 8. Tripathy SK, Black HB, Goldwasser E, Leiden JM (1996) Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nature Medicine 2:545-550.
9. 9. Wen D, Boissel JPR, Tracy TE, Gruninger RH, Mulcahy LS, Czelusniak J, Goodman M, Bunn HF (1993) Ertyhropoietin structure-function relationships: high degree of sequence homology among mammals. Blood 82:1507-1576.
10. 10. Jones T, Stern A, Lin R (1994) Potential role of granulocyte-macrophage colony-stimulating factor as vaccine adjuvant. Eur J Clin Microbiol Infect Dis 13(Suppl. 2):47-53.
11. 11. Tao MH, Levy R (1993) Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma. Nature 362:755-758.
12. 12. Curtis BM, Williams DE, Broxmeyer HE, Dunn J, Farrah T, Jeffery E, Clevenger W, DeRoos P, Martin U, Friend D, Craig V, Gayle R, Price V, Cosman D, March CJ, Park LS (1991) Enhanced hematopoietic activity of a human granulocyte/ macrophage colony-stimulating factor-interleukin 3 fusion protein. Proc Natl Acad Sci USA 88:5809-5813.
13. 13. Vadhan-Raj S, Broxmeyer H, Andreeff M, Bandres JC, Buescher ES, Benjamin RS, Papadopulos NE, Burgess A, Patel S, Plager C, Hittelman WN, McAlister I, Garrison L, Williams DE (1995) In vivo biological effects of PIXY321, a synthetic hybrid protein of recombinant human granulocyte-macrophage colony-stimulating factor and interleukin-3 in cancer patients with normal hematopoiesis: a phase I study. Blood 86: 6:2098-2105.
14. 14. Vadhan-Raj S, Papadopulos NE, Burgess M, Linke KA, Patel SR, Hays C, Arcenas A, Plager C, Kudelka AP, Hittelman WN, Broxmeyer HE, Williams DP, Garrison L, Benjamin RS (1994) Effects of PIXY321, a granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein, on chemotherapy-induced multilineage myelosuppression in patients with sarcoma. J Clin Oncol 12:715-724.
15. 15. Antonelli G (1994) Development of neutralizing and binding antibodies to Interferon (IFN) in patients undergoing IFN therapy. Antiviral Res 24:235-244.
16. 16. Allegretta M, Atkins MB, Dempsey RA, Bradley EC, Konrad MW, Childs A, Wolfe SN, Mier JW (1986) The development of anti-interleukin-2 antibodies in patients treated with recombinant human interleukin-2 (IL-2). J Clin Immunol 6:481-490.
17. 17. Ciapponi L, Maione D, Scoumanne A, Costa P, Hansen MB, Svenson M, Bendtzen K, Alonzi T, Paonessa G, Cortese R, Ciliberto G, Savino R (1997) Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist. Nature Biotechnol 15:997-1001.
18. 18. Debets R, Savelkoul FJ (1994) Cytokine antagonist and their potential therapeutic use. Immunol Today 15:445-458.
19. 19. D'Andrea AD, Youssoufian H, Zon LI, Koo JW, Lodish H (1991) The cytoplasmatic region of the erythropoietin receptor contains non overlapping positive and negative growth-regulatory domains. Mol Cell Biol 11:1980-1987.
20. 20. Lange B, Valtieri M, Santoli D, Caracciolo D, Mavilio F, Gemperlein I, Griffin C, Emanuel B, Finan J, Nowell P, Rovera G (1987) Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines. Blood 70:192-199.
21. 21. Gibaldi M, Perrier D (1982) Pharmacokinetics, (2nd Edn), New York: Marcel Dekker.