Rapid detection of hypoxia-inducible factor-1-active tumours: Pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1α

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 37, Issue 8, 2010, Pages 1566-1574

  Ueda, Masashi ^a,b   Kudo, Takashi ^b   Kuge, Yuji ^b,c   Mukai, Takahiro ^d   Tanaka, Shotaro ^b   Konishi, Hiroaki ^b   Miyano, Azusa ^b   Ono, Masahiro ^b   Kizaka Kondoh, Shinae ^b   Hiraoka, Masahiro ^b   Saji, Hideo ^b  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

Hypoxia inducible factor 1 (HIF 1); Molecular imaging; Oxygen dependent degradation (ODD); Pretargeting; Tumour hypoxia

Indexed keywords

(3 IODOBENZOYL)NORBIOTINAMIDE I 123; (3 IODOBENZOYL)NORBIOTINAMIDE I 125; BIOTIN DERIVATIVE; HYBRID PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN POS; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BIOLUMINESCENCE; DRUG DISTRIBUTION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOLECULAR IMAGING; MOUSE; NONHUMAN; PROTEIN DEGRADATION; RADIOACTIVITY; TUMOR;

ANIMALS; BIOTIN; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MOLECULAR IMAGING; PANCREATIC NEOPLASMS; STREPTAVIDIN; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 77956181702     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-010-1467-4     Document Type: Article

References (40)

1. P Vaupel F Kallinowski P Okunieff 1989 Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review Cancer Res 49 6449 6465 1:CAS:528:DyaK3cXltlSmtQ%3D%3D 2684393
2. GL Semenza 2000 Expression of hypoxia-inducible factor 1: mechanisms and consequences Biochem Pharmacol 59 47 53 10.1016/S0006-2952(99)00292-0 1:CAS:528:DC%2BD3cXhtV2htw%3D%3D 10605934
3. RH Wenger 2002 Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression FASEB J 16 1151 1162 10.1096/fj.01-0944rev 1:CAS:528: DC%2BD38XlslWrs78%3D 12153983
4. JR Ballinger 2001 Imaging hypoxia in tumors Semin Nucl Med 31 321 329 10.1053/snuc.2001.26191 1:STN:280:DC%2BD3MnmsFSgtQ%3D%3D 11710774
5. S Kizaka-Kondoh M Inoue H Harada M Hiraoka 2003 Tumor hypoxia: a target for selective cancer therapy Cancer Sci 94 1021 1028 10.1111/j.1349-7006.2003. tb01395.x 1:CAS:528:DC%2BD2cXhtlSrtbg%3D 14662015
6. BH Jiang GL Semenza C Bauer HH Marti 1996 Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension Am J Physiol 271 C1172 C1180 1:CAS:528:DyaK28XmsF2nurw%3D 8897823
7. H Harada S Kizaka-Kondoh G Li S Itasaka K Shibuya M Inoue, et al. 2007 Significance of HIF-1-active cells in angiogenesis and radioresistance Oncogene 26 7508 7516 10.1038/sj.onc.1210556 1:CAS:528:DC%2BD2sXhtlKmurvO 17563752
8. H Harada S Kizaka-Kondoh M Hiraoka 2005 Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals Mol Imaging 4 182 193 16194450
9. T Kudo M Ueda Y Kuge T Mukai S Tanaka M Masutani, et al. 2009 Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells J Nucl Med 50 942 949 10.2967/jnumed.108.061119 19443598
10. S Kizaka-Kondoh H Konse-Nagasawa 2009 Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia Cancer Sci 100 1366 1373 10.1111/j.1349-7006.2009.01195.x 1:CAS:528:DC%2BD1MXhtVWnsLrM 19459851
11. S Kizaka-Kondoh S Tanaka H Harada M Hiraoka 2009 The HIF-1-active microenvironment: an environmental target for cancer therapy Adv Drug Deliv Rev 61 623 632 10.1016/j.addr.2009.01.006 1:CAS:528:DC%2BD1MXmsFyhsb4%3D 19409433
12. NM Green 1963 Avidin. 3. The nature of the biotin-binding site Biochem J 89 599 609 1:CAS:528:DyaF2cXhtVyjtw%3D%3D 14101981
13. DM Goldenberg EA Rossi RM Sharkey WJ McBride CH Chang 2008 Multifunctional antibodies by the Dock-and-Lock method for improved cancer imaging and therapy by pretargeting J Nucl Med 49 158 163 10.2967/jnumed.107. 046185 1:CAS:528:DC%2BD1cXhs1agu70%3D 18077530
14. RM Sharkey TM Cardillo EA Rossi CH Chang H Karacay WJ McBride, et al. 2005 Signal amplification in molecular imaging by pretargeting a multivalent, bispecific antibody Nat Med 11 1250 1255 10.1038/nm1322 1:CAS:528: DC%2BD2MXhtFOhsLvL 16258537
15. RM Sharkey H Karacay S Litwin EA Rossi WJ McBride CH Chang, et al. 2008 Improved therapeutic results by pretargeted radioimmunotherapy of non-Hodgkin's lymphoma with a new recombinant, trivalent, anti-CD20, bispecific antibody Cancer Res 68 5282 5290 10.1158/0008-5472.CAN-08-0037 1:CAS:528: DC%2BD1cXnvFyjsb0%3D 18593929
16. S Kizaka-Kondoh S Itasaka L Zeng S Tanaka T Zhao Y Takahashi, et al. 2009 Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer Clin Cancer Res 15 3433 3441 10.1158/1078-0432.CCR-08-2267 1:CAS:528:DC%2BD1MXmtVKmu7Y%3D 19417024
17. CF Foulon KL Alston MR Zalutsky 1997 Synthesis and preliminary biological evaluation of (3-iodobenzoyl)norbiotinamide and ((5-iodo-3-pyridinyl)carbonyl) norbiotinamide: two radioiodinated biotin conjugates with improved stability Bioconjug Chem 8 179 186 10.1021/bc970006m 1:CAS:528:DyaK2sXhsFGjtb4%3D 9095358
18. C Motta-Hennessy RM Sharkey DM Goldenberg 1990 Metabolism of indium-111-labeled murine monoclonal antibody in tumor and normal tissue of the athymic mouse J Nucl Med 31 1510 1519 1:STN:280:DyaK3czmvFenug%3D%3D 2395019
19. S Ishino Y Kuge N Takai N Tamaki HW Strauss FG Blankenberg, et al. 2007 99mTc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits Eur J Nucl Med Mol Imaging 34 889 899 10.1007/s00259-006-0289-x 17216472
20. S Ishino T Mukai Y Kuge N Kume M Ogawa N Takai, et al. 2008 Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque J Nucl Med 49 1677 1685 10.2967/jnumed.107.049536 1:CAS:528: DC%2BD1cXhtlSgtrfJ 18794262
21. M Ueda Y Iida A Tominaga T Yoneyama M Ogawa Y Magata, et al. 2010 Nicotinic acetylcholine receptors expressed in the ventral posterolateral thalamic nucleus play an important role in antiallodynic effects Br J Pharmacol 159 1201 1210 10.1111/j.1476-5381.2009.00613.x 1:CAS:528:DC%2BC3cXjs1ektLk%3D 20136830
22. H Harada X Xie S Itasaka L Zeng Y Zhu A Morinibu, et al. 2008 Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors Biochem Biophys Res Commun 373 533 538 10.1016/j.bbrc.2008.06.062 1:CAS:528:DC%2BD1cXptVKksrg%3D 18586004
23. L Marignol M Coffey M Lawler D Hollywood 2008 Hypoxia in prostate cancer: a powerful shield against tumour destruction? Cancer Treat Rev 34 313 327 10.1016/j.ctrv.2008.01.006 1:CAS:528:DC%2BD1cXmtlWiur0%3D 18334284
24. HL Ke YC Wei SF Yang CC Li DC Wu CH Huang, et al. 2008 Overexpression of hypoxia-inducible factor-1alpha predicts an unfavorable outcome in urothelial carcinoma of the upper urinary tract Int J Urol 15 200 205 10.1111/j.1442-2042. 2007.01978.x 1:CAS:528:DC%2BD1cXkvVaktLg%3D 18304212
25. K Miyake T Yoshizumi S Imura K Sugimoto E Batmunkh H Kanemura, et al. 2008 Expression of hypoxia-inducible factor-1alpha, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: correlation with poor prognosis with possible regulation Pancreas 36 e1 e9 10.1097/MPA. 0b013e31815f2c2a 1:CAS:528:DC%2BD1cXkvVenur0%3D 18362831
26. C Trastour E Benizri F Ettore A Ramaioli E Chamorey J Pouyssegur, et al. 2007 HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome Int J Cancer 120 1451 1458 10.1002/ijc.22436 1:CAS:528:DC%2BD2sXis12is7Y%3D 17245699
27. G Mees R Dierckx C Vangestel C Van de Wiele 2009 Molecular imaging of hypoxia with radiolabelled agents Eur J Nucl Med Mol Imaging 36 1674 1686 10.1007/s00259-009-1195-9 1:CAS:528:DC%2BD1MXht1WhtLrI 19565239
28. MP Dunphy JS Lewis 2009 Radiopharmaceuticals in preclinical and clinical development for monitoring of therapy with PET J Nucl Med 50 Suppl 1 106S 121S 10.2967/jnumed.108.057281 1:CAS:528:DC%2BD1MXmtFahtr4%3D 19380404
29. KA Krohn JM Link RP Mason 2008 Molecular imaging of hypoxia J Nucl Med 49 Suppl 2 129S 148S 10.2967/jnumed.107.045914 1:CAS:528:DC%2BD1cXotFahu78%3D 18523070
30. F He X Deng B Wen Y Liu X Sun L Xing, et al. 2008 Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers Cancer Res 68 8597 8606 10.1158/0008-5472.CAN-08-0677 1:CAS:528:DC%2BD1cXht1CmsbjP 18922936
31. CJ Yeom JK Chung JH Kang YH Jeon KI Kim YN Jin, et al. 2008 Visualization of hypoxia-inducible factor-1 transcriptional activation in C6 glioma using luciferase and sodium iodide symporter genes J Nucl Med 49 1489 1497 10.2967/jnumed.107.044461 1:CAS:528:DC%2BD1cXhtFOju7fK 18703592
32. S Sobhanifar C Aquino-Parsons EJ Stanbridge P Olive 2005 Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors Cancer Res 65 7259 7266 10.1158/0008-5472.CAN-04-4480 1:CAS:528:DC%2BD2MXns1Wrurs%3D 16103077
33. XF Li S Carlin M Urano J Russell CC Ling JA O'Donoghue 2007 Visualization of hypoxia in microscopic tumors by immunofluorescent microscopy Cancer Res 67 7646 7653 10.1158/0008-5472.CAN-06-4353 1:CAS:528:DC%2BD2sXptVGlsLg%3D 17699769
34. I Serganova M Doubrovin J Vider V Ponomarev S Soghomonyan T Beresten, et al. 2004 Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice Cancer Res 64 6101 6108 10.1158/0008-5472.CAN-04-0842 1:CAS:528: DC%2BD2cXntFClsLk%3D 15342393
35. CH Hsieh JW Kuo YJ Lee CW Chang JG Gelovani RS Liu 2009 Construction of mutant TKGFP for real-time imaging of temporal dynamics of HIF-1 signal transduction activity mediated by hypoxia and reoxygenation in tumors in living mice J Nucl Med 50 2049 2057 10.2967/jnumed.108.061234 1:CAS:528: DC%2BC3cXjvVansg%3D%3D 19910419
36. B Wen P Burgman P Zanzonico J O'Donoghue S Cai R Finn, et al. 2004 A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxia Eur J Nucl Med Mol Imaging 31 1530 1538 10.1007/s00259-004-1673-z 1:CAS:528:DC%2BD2cXptVejtr8%3D 15378285
37. M Ioannou R Papamichali E Kouvaras I Mylonis D Vageli T Kerenidou, et al. 2009 Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma Lung 187 321 329 10.1007/s00408-009-9169- z 1:CAS:528:DC%2BD1MXhtFCjurzO 19707816
38. GB van den Broek M Wildeman CR Rasch N Armstrong E Schuuring AC Begg, et al. 2009 Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin-based chemoradiation Int J Cancer 124 2643 2650 10.1002/ijc.24254 19253368
39. S North M Moenner A Bikfalvi 2005 Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors Cancer Lett 218 1 14 10.1016/j.canlet.2004.08.007 1:CAS:528:DC%2BD2MXitFelsA%3D%3D 15639335
40. HD Skinner JZ Zheng J Fang F Agani BH Jiang 2004 Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling J Biol Chem 279 45643 45651 10.1074/jbc.M404097200 1:CAS:528:DC%2BD2cXovVCns7k%3D 15337760