Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with99mTc-labeled anti-LOX-1 antibody: Potential agent for imaging of vulnerable plaque

Journal of Nuclear Medicine

Volumn 49, Issue 10, 2008, Pages 1677-1685

  Ishino, Seigo ^a   Mukai, Takahiro ^b   Kuge, Yuji ^a   Kume, Noriaki ^a   Ogawa, Mikako ^c   Takai, Nozomi ^a   Kamihashi, Junko ^a   Shiomi, Masashi ^d   Minami, Manabu ^a   Kita, Toru ^a   Saji, Hideo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antibody; Atherosclerosis; Imaging; Plaque; Receptor

Indexed keywords

6 HYDRAZINONICOTINIC ACID; IMMUNOGLOBULIN G2A; LOX 1 MONOCLONAL ANTIBODY TC 99M; NICOTINIC ACID DERIVATIVE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROMATOSIS; ATHEROSCLEROTIC PLAQUE; AUTORADIOGRAPHY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG TARGETING; FEMALE; HEART INFARCTION; HYPERLIPIDEMIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOACTIVITY;

ANIMALS; ANTIBODIES, MONOCLONAL; AORTA; ATHEROSCLEROSIS; DIAGNOSTIC IMAGING; FEMALE; FLUORODEOXYGLUCOSE F18; HYPERLIPIDEMIAS; IMMUNOGLOBULIN G; MALE; RABBITS; RADIOPHARMACEUTICALS; SCAVENGER RECEPTORS, CLASS E; TECHNETIUM;

EID: 53749092641     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.107.049536     Document Type: Article

References (38)

1. Lendon C, Born GV, Davies MJ, Richardson PD. Plaque fissure: the link between atherosclerosis and thrombosis. Nouv Rev Fr Hematol. 1992;34:27-29.
2. Ruberg FL, Leopold JA, Loscalzo J. Atherothrombosis: plaque instability and thrombogenesis. Prog Cardiovasc Dis. 2002;44:381-394.
3. Kolodgie FD, Virmani R, Burke AP, et al. Pathologic assessment of the vulnerable human coronary plaque. Heart. 2004;90:1385-1391.
4. Sawamura T, Kume N, Aoyama T, et al. An endothelial receptor for oxidized low-density lipoprotein. Nature. 1997;386:73-77.
5. Kume N, Kita T. Roles of lectin-like oxidized LDL receptor-1 and its soluble forms in atherogenesis. Curr Opin Lipidol. 2001;12:419-423.
6. Moriwaki H, Kume N, Kataoka H, et al. Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-alpha. FEBS Lett. 1998;440:29-32.
7. Kataoka H, Kume N, Miyamoto S, et al. Oxidized LDL modulates Bax/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2001;21:955-960.
8. Kume N, Kita T. Apoptosis of vascular cells by oxidized LDL: involvement of caspases and LOX-1 and its implication in atherosclerotic plaque rupture. Circ Res. 2004;94:269-270.
9. Li D, Liu L, Chen H, et al. LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells. Circulation. 2003;107:612-617.
10. Ishino S, Mukai T, Kume N, et al. Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability: analysis in hypercholesterolemic rabbits. Atherosclerosis. 2007;195:48-56.
11. Jaffer FA, Libby P, Weissleder R. Molecular and cellular imaging of atherosclerosis: emerging applications. J Am Coll Cardiol. 2006;47:1328-1338.
12. Davies JR, Rudd JH, Weissberg PL. Molecular and metabolic imaging of atherosclerosis. J Nucl Med. 2004;45:1898-1907.
13. Shiomi M, Ito T, Yamada S, et al. Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit). Arterioscler Thromb Vasc Biol. 2003;23:1239-1244.
14. Eto H, Miyata M, Kume N, et al. Expression of lectin-like oxidized LDL receptor-1 in smooth muscle cells after vascular injury. Biochem Biophys Res Commun. 2006;341:591-598.
15. Abrams MJ, Juweid M, tenKate CI, et al. Technetium-99m-human polyclonal IgG radiolabeled via the hydrazino nicotinamide derivative for imaging focal sites of infection in rats. J Nucl Med. 1990;31:2022-2028.
16. 99mTc-labeled hydrazino nicotinamide derivatized polypeptides and peptides. Nucl Med Biol. 2001;28:155-164.
17. 99mTc]tricine: a useful precursor complex for the radiolabeling of hydrazinonicotinate protein conjugates. Bioconjug Chem. 1995;6:635-638.
18. Ishii K, Kita T, Kume N, Nagano Y, Kawai C. Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia. Biochim Biophys Acta. 1988;962:387-389.
19. 99mF-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study. J Nucl Med. 2004;45:1245-1250.
20. Stary HC, Chandler AB, Glagov S, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1994;89:2462-2478.
21. Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995;92:1355-1374.
22. Kobayashi S, Inoue N, Ohashi Y, et al. Interaction of oxidative stress and inflammatory response in coronary plaque instability: important role of C-reactive protein. Arterioscler Thromb Vasc Biol. 2003;23:1398-1404.
23. Shiomi M, Ito T, Hirouchi Y, et al. Stability of atheromatous plaque affected by lesional composition: study of WHHL rabbits treated with statins. Ann N Y Acad Sci. 2001;947:419-423.
24. Mann JM, Davies MJ. Vulnerable plaque: relation of characteristics to degree of stenosis in human coronary arteries. Circulation. 1996;94:928-931.
25. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation. 1995;92:657-671.
26. Shiomi M, Ito T, Hirouchi Y, et al. Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins. Atherosclerosis. 2001;157:75-84.
27. Chen M, Kakutani M, Minami M, et al. Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol. 2000;20:1107-1115.
28. Tsimikas S, Palinski W, Halpern SE, Yeung DW, Curtiss LK, Witztum JL. Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo. J Nucl Cardiol. 1999;6:41-53.
29. Tsimikas S, Shaw PX. Non-invasive imaging of vulnerable plaques by molecular targeting of oxidized LDL with tagged oxidation-specific antibodies. J Cell Biochem Suppl. 2002;39:138-146.
30. Christensen S, Nielsen H. Permeability of arterial endothelium to plasma macromolecules. Atherosclerosis. 1977;27:447-463.
31. Smith EB, Staples EM. Distribution of plasma proteins across the human aortic wall: barrier functions of endothelium and internal elastic lamina. Atherosclerosis. 1980;37:579-590.
32. 18F]-fluorodeoxyglucose positron emission tomography. Circulation. 2002;105:2708-2711.
33. 99mTc-annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits. Eur J Nucl Med Mol Imaging. 2007;34:889-899.
34. Kietselaer BL, Reutelingsperger CP, Heidendal GA, et al. Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotidartery atherosclerosis. N Engl J Med. 2004;350:1472-1473.
35. 99mTc-annexin V imaging for in vivo detection of atherosclerotic lesions in porcine coronary arteries. J Nucl Med. 2005;46:1186-1193.
36. Behr TM, Becker WS, Bair HJ, et al. Comparison of complete versus fragmented technetium-99m-labeled anti-CEA monoclonal antibodies for immunoscintigraphy in colorectal cancer. J Nucl Med. 1995;36:430-441.
37. Sharkey RM, Karacay H, Cardillo TM, et al. Improving the delivery of radionuclides for imaging and therapy of cancer using pretargeting methods. Clin Cancer Res. 2005;11:7109-7121.
38. Sakahara H, Saga T. Avidin-biotin system for delivery of diagnostic agents. Adv Drug Deliv Rev. 1999;37:89-101.