Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone: Reversed binding orientations in different redox states of the enzyme

Journal of Biological Chemistry

Volumn 280, Issue 14, 2005, Pages 13256-13264

  Race, Paul R ^a   Lovering, Andrew L ^a,c   Green, Richard M ^a   Ossor, Abdelmijd ^a,d   White, Scott A ^a   Searle, Peter F ^a   Wrighton, Christopher J ^b,e   Hyde, Eva I ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ML Laboratories ^*  (United Kingdom)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d STONY BROOK UNIVERSITY   (United States)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CATALYSIS; CRYSTAL STRUCTURE; ENZYMES; PROTEINS; REDOX REACTIONS; REDUCTION;

ANTIBACTERIAL AGENTS; FLAVOPROTEINS; NITROREDUCTASE (NTR); REDOX STATES;

ESCHERICHIA COLI;

AMIDE; ANTIBIOTIC AGENT; BACTERIAL ENZYME; FLAVINE MONONUCLEOTIDE; HYDROXYLAMINE; NITROFURAL; NITROREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

ACETATES; ANTI-INFECTIVE AGENTS, LOCAL; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAD; NITROFURAZONE; NITROREDUCTASES; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 17144417314     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409652200     Document Type: Article

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