New Insights into the Dynamics of Cell Adhesions

International Review of Cell and Molecular Biology

Volumn 283, Issue C, 2010, Pages 57-91

  Costa, Patricia ^a   Parsons, Maddy ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cadherin; Cell adhesion; Cytoskeleton; Dynamics; Extracellular matrix; Integrin; Microscopy; Signaling

Indexed keywords

ACTIN; ADAPTOR PROTEIN; CELL PROTEIN; INTEGRIN;

BLEACHING; BOOK; CELL ADHESION; CELL CONTACT; CONFOCAL MICROSCOPY; CYTOSKELETON; EXTRACELLULAR MATRIX; FLUORESCENCE; FLUORESCENCE MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; MICROTUBULE; NONHUMAN; PHOTOACTIVATION; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN STRUCTURE; REGULATORY MECHANISM;

EID: 77956143566     PISSN: 19376448     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1937-6448(10)83002-3     Document Type: Chapter

References (141)

1. Albiges-Rizo C., Destaing O., Fourcade B., Planus E., Block M.R. Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions. J. Cell Sci. 2009, 122:3037-3049.
2. Anilkumar N., Parsons M., Monk R., Ng T., Adams J.C. Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. EMBO J. 2003, 22:5390-5402.
3. Artym V.V., Zhang Y., Seillier-Moiseiwitsch F., Yamada K.M., Mueller S.C. Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res. 2006, 66:3034-3043.
4. Askari J.A., Buckley P.A., Mould A.P., Humphries M.J. Linking integrin conformation to function. J. Cell Sci. 2009, 122:165-170.
5. Bacac M., Stamenkovic I. Metastatic cancer cell. Annu. Rev. Pathol. 2008, 3:221-247.
6. Bacallao R., Antony C., Dotti C., Karsenti E., Stelzer E.H., Simons K. The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium. J. Cell Biol. 1989, 109:2817-2832.
7. Badowski C., Pawlak G., Grichine A., Chabadel A., Oddou C., Jurdic P., et al. Paxillin phosphorylation controls invadopodia/podosomes spatiotemporal organization. Mol. Biol. Cell 2008, 19:633-645.
8. Banno A., Ginsberg M.H. Integrin activation. Biochem. Soc. Trans. 2008, 36:229-234.
9. Bartolini F., Gundersen G.G. Generation of noncentrosomal microtubule arrays. J. Cell Sci. 2006, 119:4155-4163.
10. Bass M.D., Roach K.A., Morgan M.R., Mostafavi-Pour Z., Schoen T., Muramatsu T., et al. Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J. Cell Biol. 2007, 177:527-538.
11. Bear J.E., Gertler F.B. Ena/VASP: towards resolving a pointed controversy at the barbed end. J. Cell Sci. 2009, 122:1947-1953.
12. Betzig E., Patterson G.H., Sougrat R., Lindwasser O.W., Olenych S., Bonifacino J.S., et al. Imaging intracellular fluorescent proteins at nanometer resolution. Science 2006, 313:1642-1645.
13. Bianco A., Poukkula M., Cliffe A., Mathieu J., Luque C.M., Fulga T.A., et al. Two distinct modes of guidance signalling during collective migration of border cells. Nature 2007, 448:362-365.
14. Bretscher M.S. Endocytosis and recycling of the fibronectin receptor in CHO cells. EMBO J. 1989, 8:1341-1348.
15. Broussard J.A., Webb D.J., Kaverina I. Asymmetric focal adhesion disassembly in motile cells. Curr. Opin. Cell Biol. 2007, 20:85-90.
16. Brown E.J. Integrin-associated proteins. Curr. Opin. Cell Biol. 2002, 14:603-607.
17. Brown M.C., Cary L.A., Jamieson J.S., Cooper J.A., Turner C.E. Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol. Biol. Cell 2005, 16:4316-4328.
18. Brown C.M., Hebert B., Kolin D.L., Zareno J., Whitmore L., Horwitz A.R., et al. Probing the integrin-actin linkage using high-resolution protein velocity mapping. J. Cell Sci. 2006, 119:5204-5214.
19. Cadigan K.M., Peifer M. Wnt signaling from development to disease: insights from model systems. Cold Spring Harb. Perspect. Biol. 2009, 1:a002881.
20. Cai Y., Sheetz M.P. Force propagation across cells: mechanical coherence of dynamic cytoskeletons. Curr. Opin. Cell Biol. 2009, 21:47-50.
21. Campagnola P.J., Clark H.A., Mohler W.A., Lewis A., Loew L.M. Second-harmonic imaging microscopy of living cells. J. Biomed. Opt. 2001, 6:277-286.
22. Caplan M.J., Seo-Mayer P., Zhang L. Epithelial junctions and polarity: complexes and kinases. Curr. Opin. Nephrol. Hypertens. 2008, 17:506-512.
23. Caswell P.T., Spence H.J., Parsons M., White D.P., Clark K., Cheng K.W., et al. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev. Cell 2007, 13:496-510.
24. Caswell P.T., Chan M., Lindsay A.J., McCaffrey M.W., Boettiger D., Norman J.C. Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments. J. Cell Biol. 2008, 183:143-155.
25. Caswell P.T., Vadrevu S., Norman J.C. Integrins: masters and slaves of endocytic transport. Nat. Rev. Mol. Cell Biol. 2009, 10:843-853.
26. Cavey M., Lecuit T. Molecular bases of cell-cell junctions stability and dynamics. Cold Spring Harb. Perspect. Biol. 2009, 1:a002998.
27. Cavey M., Rauzi M., Lenne P.F., Lecuit T. A two-tiered mechanism for stabilization and immobilization of E-cadherin. Nature 2008, 453:751-756.
28. Chan K.T., Cortesio C.L., Huttenlocher A. FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. J. Cell Biol. 2009, 185:357-370.
29. Chan K.T., Bennin D.A., Huttenlocher A. Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J. Biol. Chem. 2010, 285:11418-11426.
30. Choi C.K., Vicente-Manzanares M., Zareno J., Whitmore L.A., Mogilner A., Horwitz A.R. Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat. Cell Biol. 2008, 10:1039-1050.
31. Cortesio C.L., Chan K.T., Perrin B.J., Burton N.O., Zhang S., Zhang Z.Y., et al. Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. J. Cell Biol. 2008, 180:957-971.
32. Critchley D.R., Gingras A.R. Talin at a glance. J. Cell Sci. 2008, 121:1345-1347.
33. Cukierman E., Pankov R., Stevens D.R., Yamada K.M. Taking cell-matrix adhesions to the third dimension. Science 2001, 294:1708-1712.
34. Deane J.A., Hickey M.J. Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging. Expert Rev. Mol. Med. 2009, 11:e25.
35. Dejana E. Endothelial cell-cell junctions: happy together. Nat. Rev. Mol. Cell Biol. 2004, 5:261-270.
36. DeMali K.A., Barlow C.A., Burridge K. Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. J. Cell Biol. 2002, 159:881-891.
37. DerMardirossian C., Bokoch G.M. GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol. 2005, 15:356-363.
38. DesMarais V., Ghosh M., Eddy R., Condeelis J. Cofilin takes the lead. J. Cell Sci. 2005, 118:19-26.
39. Destaing O., Saltel F., Geminard J.C., Jurdic P., Bard F. Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein. Mol. Biol. Cell 2003, 14:407-416.
40. Digman M.A., Wiseman P.W., Choi C., Horwitz A.R., Gratton E. Stoichiometry of molecular complexes at adhesions in living cells. Proc. Natl. Acad. Sci. USA 2009, 106:2170-2175.
41. Drees F., Pokutta S., Yamada S., Nelson W.J., Weis W.I. Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell 2005, 123:903-915.
42. Dubash A.D., Menold M.M., Samson T., Boulter E., Garcia-Mata R., Doughman R., et al. Chapter 1. Focal adhesions: new angles on an old structure. Int. Rev. Cell. Mol. Biol. 2009, 277:1-65.
43. Efimov A., Schiefermeier N., Grigoriev I., Ohi R., Brown M.C., Turner C.E., et al. Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. J. Cell Sci. 2008, 121:196-204.
44. Epstein Jr.E.H. The genetics of human skin diseases. Curr. Opin. Genet. Dev. 1996, 6:295-300.
45. Ezratty E.J., Partridge M.A., Gundersen G.G. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat. Cell Biol. 2005, 7:581-590.
46. Farmer C., Morton P.E., Snippe M., Santis G., Parsons M. Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK. Exp. Cell Res. 2009, 315:2637-2647.
47. Franco S.J., Rodgers M.A., Perrin B.J., Han J., Bennin D.A., Critchley D.R., et al. Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat. Cell Biol. 2004, 6:977-983.
48. Fukata M., Kaibuchi K. Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nat. Rev. Mol. Cell Biol. 2001, 2:887-897.
49. Gallant N.D., Michael K.E., Garcia A.J. Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly. Mol. Biol. Cell 2005, 16:4329-4340.
50. Giannone G., Dubin-Thaler B.J., Rossier O., Cai Y., Chaga O., Jiang G., et al. Lamellipodial actin mechanically links myosin activity with adhesion-site formation. Cell 2007, 128:561-575.
51. Giepmans B.N., van Ijzendoorn S.C. Epithelial cell-cell junctions and plasma membrane domains. Biochim. Biophys. Acta 2009, 1788:820-831.
52. Godsel L.M., Hsieh S.N., Amargo E.V., Bass A.E., Pascoe-McGillicuddy L.T., Huen A.C., et al. Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin. J. Cell Biol. 2005, 171:1045-1059.
53. Goldyn A.M., Rioja B.A., Spatz J.P., Ballestrem C., Kemkemer R. Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding. J. Cell Sci. 2009, 122:3644-3651.
54. Green K.J., Simpson C.L. Desmosomes: new perspectives on a classic. J. Invest. Dermatol. 2007, 127:2499-2515.
55. Green J.A., Yamada K.M. Three-dimensional microenvironments modulate fibroblast signaling responses. Adv. Drug Deliv. Rev. 2007, 59:1293-1298.
56. Habas R., He X. Activation of Rho and Rac by Wnt/frizzled signaling. Meth. Enzymol. 2006, 406:500-511.
57. Harburger D.S., Calderwood D.A. Integrin signalling at a glance. J. Cell Sci. 2009, 122:159-163.
58. Hashimoto Y., Parsons M., Adams J.C. Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis. Mol. Biol. Cell 2007, 18:4591-4602.
59. Himmel M., Ritter A., Rothemund S., Pauling B.V., Rottner K., Gingras A.R., et al. Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions. J. Biol. Chem. 2009, 284:13832-13842.
60. Hotulainen P., Lappalainen P. Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J. Cell Biol. 2006, 173:383-394.
61. Hu Y.L., Chien S. Dynamic motion of paxillin on actin filaments in living endothelial cells. Biochem. Biophys. Res. Commun. 2007, 357:871-876.
62. Hu K., Ji L., Applegate K.T., Danuser G., Waterman-Storer C.M. Differential transmission of actin motion within focal adhesions. Science 2007, 315:111-115.
63. Huang C., Rajfur Z., Yousefi N., Chen Z., Jacobson K., Ginsberg M.H. Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat. Cell Biol. 2009, 11:624-630.
64. Humphries J.D., Byron A., Humphries M.J. Integrin ligands at a glance. J. Cell Sci. 2006, 119:3901-3903.
65. Humphries J.D., Byron A., Bass M.D., Craig S.E., Pinney J.W., Knight D., et al. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci. Signal. 2009, 2:ra51.
66. Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 2002, 110:673-687.
67. Iwanicki M.P., Vomastek T., Tilghman R.W., Martin K.H., Banerjee J., Wedegaertner P.B., et al. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. J. Cell Sci. 2008, 121:895-905.
68. Izzard C.S., Lochner L.R. Formation of cell-to-substrate contacts during fibroblast motility: an interference-reflexion study. J. Cell Sci. 1980, 42:81-116.
69. Johnson J.L., Winterwood N., DeMali K.A., Stipp C.S. Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts. J. Cell Sci. 2009, 122:2263-2273.
70. Joshi B., Strugnell S.S., Goetz J.G., Kojic L.D., Cox M.E., Griffith O.L., et al. Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. Cancer Res. 2008, 68:8210-8220.
71. Kametani Y., Takeichi M. Basal-to-apical cadherin flow at cell junctions. Nat. Cell Biol. 2007, 9:92-98.
72. Kaverina I., Rottner K., Small J.V. Targeting, capture, and stabilization of microtubules at early focal adhesions. J. Cell Biol. 1998, 142:181-190.
73. Kiuchi T., Ohashi K., Kurita S., Mizuno K. Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomers. J. Cell Biol. 2007, 177:465-476.
74. Kjenseth A., Fykerud T., Rivedal E., Leithe E. Regulation of gap junction intercellular communication by the ubiquitin system. Cell. Signal. 2010, 22:1267-1273.
75. Kojima T., Murata M., Go M., Spray D.C., Sawada N. Connexins induce and maintain tight junctions in epithelial cells. J. Membr. Biol. 2007, 217:13-19.
76. Koster R.W., Fraser S.E. Direct imaging of in vivo neuronal migration in the developing cerebellum. Curr. Biol. 2001, 11:1858-1863.
77. Lai-Cheong J.E., Parsons M., McGrath J.A. The role of kindlins in cell biology and relevance to human disease. Int. J. Biochem. Cell Biol. 2009, 42:595-603.
78. Langer H.F., Chavakis T. Leukocyte-endothelial interactions in inflammation. J. Cell. Mol. Med. 2009, 13:1211-1220.
79. Lee J.Y., Marston D.J., Walston T., Hardin J., Halberstadt A., Goldstein B. Wnt/Frizzled signaling controls C. elegans gastrulation by activating actomyosin contractility. Curr. Biol. 2006, 16:1986-1997.
80. Li F., Higgs H.N. The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition. Curr. Biol. 2003, 13:1335-1340.
81. Ligon L.A., Holzbaur E.L. Microtubules tethered at epithelial cell junctions by dynein facilitate efficient junction assembly. Traffic 2007, 8:808-819.
82. Linder S. The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol. 2007, 17:107-117.
83. Machacek M., Hodgson L., Welch C., Elliott H., Pertz O., Nalbant P., et al. Coordination of Rho GTPase activities during cell protrusion. Nature 2009, 461:99-103.
84. Margadant C., Frijns E., Wilhelmsen K., Sonnenberg A. Regulation of hemidesmosome disassembly by growth factor receptors. Curr. Opin. Cell Biol. 2008, 20:589-596.
85. Marshall T.W., Aloor H.L., Bear J.E. Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. J. Cell Sci. 2009, 122:3061-3069.
86. Meng W., Mushika Y., Ichii T., Takeichi M. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell 2008, 135:948-959.
87. Miller A.L., Wang Y., Mooseker M.S., Koleske A.J. The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. J. Cell Biol. 2004, 165:407-419.
88. Morgan M.R., Humphries M.J., Bass M.D. Synergistic control of cell adhesion by integrins and syndecans. Nat. Rev. Mol. Cell Biol. 2007, 8:957-969.
89. Narumiya S., Tanji M., Ishizaki T. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev. 2009, 28:65-76.
90. Nermut M.V., Green N.M., Eason P., Yamada S.S., Yamada K.M. Electron microscopy and structural model of human fibronectin receptor. EMBO J. 1988, 7:4093-4099.
91. Nobes C.D., Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995, 81:53-62.
92. Ochoa G.C., Slepnev V.I., Neff L., Ringstad N., Takei K., Daniell L., et al. A functional link between dynamin and the actin cytoskeleton at podosomes. J. Cell Biol. 2000, 150:377-389.
93. Osborn E.A., Rabodzey A., Dewey Jr.C.F., Hartwig J.H. Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress. Am. J. Physiol. Cell Physiol. 2006, 290:C444-C452.
94. Oser M., Yamaguchi H., Mader C.C., Bravo-Cordero J.J., Arias M., Chen X., et al. Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J. Cell Biol. 2009, 186:571-587.
95. Palazzo A.F., Cook T.A., Alberts A.S., Gundersen G.G. mDia mediates Rho-regulated formation and orientation of stable microtubules. Nat. Cell Biol. 2001, 3:723-729.
96. Papusheva E., Mello de Queiroz F., Dalous J., Han Y., Esposito A., Jares-Erijmanxa E.A., et al. Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility. J. Cell Sci. 2009, 122:656-666.
97. Parsons M., Adams J.C. Rac regulates the interaction of fascin with protein kinase C in cell migration. J. Cell Sci. 2008, 121:2805-2813.
98. Parsons M., Messent A.J., Humphries J.D., Deakin N.O., Humphries M.J. Quantification of integrin receptor agonism by fluorescence lifetime imaging. J. Cell Sci. 2008, 121:265-271.
99. Peng X., Cuff L.E., Lawton C.D., DeMali K.A. Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J. Cell Sci. 2010, 123:567-577.
100. Pollard T.D., Borisy G.G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003, 112:453-465.
101. Prasad M., Montell D.J. Cellular and molecular mechanisms of border cell migration analyzed using time-lapse live-cell imaging. Dev. Cell 2007, 12:997-1005.
102. Puklin-Faucher E., Sheetz M.P. The mechanical integrin cycle. J. Cell Sci. 2009, 122:179-186.
103. Reddig P.J., Juliano R.L. Clinging to life: cell to matrix adhesion and cell survival. Cancer Metastasis Rev. 2005, 24:425-439.
104. Reynolds A.R., Hart I.R., Watson A.R., Welti J.C., Silva R.G., Robinson S.D., et al. Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat. Med. 2009, 15:392-400.
105. Ridley A.J., Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992, 70:389-399.
106. Ridley A.J., Paterson H.F., Johnston C.L., Diekmann D., Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 1992, 70:401-410.
107. Robles E., Gomez T.M. Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding. Nat. Neurosci. 2006, 9:1274-1283.
108. Sahai E. Illuminating the metastatic process. Nat. Rev. Cancer 2007, 7:737-749.
109. Sahai E., Wyckoff J., Philippar U., Segall J.E., Gertler F., Condeelis J. Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy. BMC Biotechnol. 2005, 5:14.
110. Serrels B., Serrels A., Brunton V.G., Holt M., McLean G.W., Gray C.H., et al. Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat. Cell Biol. 2007, 9:1046-1056.
111. Serrels A., Timpson P., Canel M., Schwarz J.P., Carragher N.O., Frame M.C., et al. Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development. Cancer Res. 2009, 69:2714-2719.
112. Shaner N.C., Patterson G.H., Davidson M.W. Advances in fluorescent protein technology. J. Cell Sci. 2007, 120:4247-4260.
113. Shulman Z., Shinder V., Klein E., Grabovsky V., Yeger O., Geron E., et al. Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity 2009, 30:384-396.
114. Simpson K.J., Selfors L.M., Bui J., Reynolds A., Leake D., Khvorova A., et al. Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat. Cell Biol. 2008, 10:1027-1038.
115. Stehbens S.J., Paterson A.D., Crampton M.S., Shewan A.M., Ferguson C., Akhmanova A., et al. Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts. J. Cell Sci. 2006, 119:1801-1811.
116. Stramer B., Wood W., Galko M.J., Redd M.J., Jacinto A., Parkhurst S.M., et al. Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J. Cell Biol. 2005, 168:567-573.
117. Symons M., Segall J.E. Rac and Rho driving tumor invasion: who's at the wheel?. Genome Biol. 2009, 10:213.
118. Tadokoro S., Shattil S.J., Eto K., Tai V., Liddington R.C., de Pereda J.M., et al. Talin binding to integrin beta tails: a final common step in integrin activation. Science 2003, 302:103-106.
119. Takada Y., Ye X., Simon S. The integrins. Genome Biol. 2007, 8:215.
120. Takagi J., Erickson H.P., Springer T.A. C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1. Nat. Struct. Biol. 2001, 8:412-416.
121. Tomar A., Lim S.T., Lim Y., Schlaepfer D.D. A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J. Cell Sci. 2009, 122:1852-1862.
122. Totsukawa G., Wu Y., Sasaki Y., Hartshorne D.J., Yamakita Y., Yamashiro S., et al. Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts. J. Cell Biol. 2004, 164:427-439.
123. Vicente-Manzanares M., Choi C.K., Horwitz A.R. Integrins in cell migration-the actin connection. J. Cell Sci. 2009, 122:199-206.
124. Wallis S., Lloyd S., Wise I., Ireland G., Fleming T.P., Garrod D. The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells. Mol. Biol. Cell 2000, 11:1077-1092.
125. Waterman-Storer C.M., Desai A., Bulinski J.C., Salmon E.D. Fluorescent speckle microscopy, a method to visualize the dynamics of protein assemblies in living cells. Curr. Biol. 1998, 8:1227-1230.
126. Webb D.J., Donais K., Whitmore L.A., Thomas S.M., Turner C.E., Parsons J.T., et al. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 2004, 6:154-161.
127. Wherlock M., Mellor H. The Rho GTPase family: a Racs to Wrchs story. J. Cell Sci. 2002, 115:239-240.
128. Winograd-Katz S.E., Itzkovitz S., Kam Z., Geiger B. Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. J. Cell Biol. 2009, 186:423-436.
129. Wolf K., Wu Y.I., Liu Y., Geiger J., Tam E., Overall C., et al. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat. Cell Biol. 2007, 9:893-904.
130. Worth D.C., Parsons M. Adhesion dynamics: mechanisms and measurements. Int. J. Biochem. Cell Biol. 2008, 40:2397-2409.
131. Wozniak M.A., Modzelewska K., Kwong L., Keely P.J. Focal adhesion regulation of cell behavior. Biochim. Biophys. Acta 2004, 1692:103-119.
132. Xiong J.P., Li R., Essafi M., Stehle T., Arnaout M.A. An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain. J. Biol. Chem. 2000, 275:38762-38767.
133. Xiong J.P., Stehle T., Diefenbach B., Zhang R., Dunker R., Scott D.L., et al. Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science 2001, 294:339-345.
134. Yamada S., Pokutta S., Drees F., Weis W.I., Nelson W.J. Deconstructing the cadherin-catenin-actin complex. Cell 2005, 123:889-901.
135. Yauch R.L., Kazarov A.R., Desai B., Lee R.T., Hemler M.E. Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J. Biol. Chem. 2000, 275:9230-9238.
136. Yoo S.K., Deng Q., Cavnar P.J., Wu Y.I., Hahn K.M., Huttenlocher A. Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev. Cell 2010, 18:226-236.
137. Yuan L., Fairchild M.J., Perkins A.D., Tanentzapf G. Analysis of integrin turnover in fly myotendinous junctions. J. Cell Sci. 2010, 123:939-946.
138. Zaidel-Bar R., Ballestrem C., Kam Z., Geiger B. Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J. Cell Sci. 2003, 116:4605-4613.
139. Zaidel-Bar R., Cohen M., Addadi L., Geiger B. Hierarchical assembly of cell-matrix adhesion complexes. Biochem. Soc. Trans. 2004, 32:416-420.
140. Zaidel-Bar R., Itzkovitz S., Ma'ayan A., Iyengar R., Geiger B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007, 9:858-867.
141. Zhang X., Jiang G., Cai Y., Monkley S.J., Critchley D.R., Sheetz M.P. Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat. Cell Biol. 2008, 10:1062-1068.