-
1
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-1186 (1971).
-
(1971)
N. Engl. J. Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
2
-
-
0015311426
-
Anti-angiogenesis: New concept for therapy of solid tumors
-
Folkman, J. Anti-angiogenesis: new concept for therapy of solid tumors. Ann. Surg. 175,409-416 (1972).
-
(1972)
Ann. Surg.
, vol.175
, pp. 409-416
-
-
Folkman, J.1
-
3
-
-
0036780251
-
Clinical translation of angiogenesis inhibitors
-
Kerbel, R, & Folkman, J. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2, 727-739 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 727-739
-
-
Kerbel, R.1
Folkman, J.2
-
4
-
-
0024281381
-
A zinc-finger encoding gene corregulated with c-Fos during growth and differentiation and after depolarization
-
Sukhatme, V.P. et al. A zinc-finger encoding gene corregulated with c-Fos during growth and differentiation and after depolarization. Cell 53, 37-43 (1988).
-
(1988)
Cell
, vol.53
, pp. 37-43
-
-
Sukhatme, V.P.1
-
5
-
-
0029161198
-
Early growth response protein 1 (Egr-1): Prototype of a zinc-finger family of transcription factors
-
Gashler, A. & Sukhatme, V. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog, Nucl. Acid Res, 50, 191-224 (1995).
-
(1995)
Prog. Nucl. Acid Res.
, vol.50
, pp. 191-224
-
-
Gashler, A.1
Sukhatme, V.2
-
6
-
-
0029996110
-
Egr-1-induced endothelial gene expression: A common theme in vascular injury
-
Khachigian, L.M., Lindner, V., Williams, A.J. & Collins, T. Egr-1-induced endothelial gene expression: a common theme in vascular injury, Science 271, 1427-1431 (1996).
-
(1996)
Science
, vol.271
, pp. 1427-1431
-
-
Khachigian, L.M.1
Lindner, V.2
Williams, A.J.3
Collins, T.4
-
7
-
-
0030818274
-
Inducible expression of Egr-1-dependent genes: A paradigm of transcriptional activation in vascular endothelium
-
Khachigian, L.M. & Collins, T. Inducible expression of Egr-1-dependent genes: a paradigm of transcriptional activation in vascular endothelium. Circ. Res, 81, 457-461 (1997).
-
(1997)
Circ. Res.
, vol.81
, pp. 457-461
-
-
Khachigian, L.M.1
Collins, T.2
-
9
-
-
0021055582
-
In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices
-
Montesano, R., Orci, L. & Vassalli, P. In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices. J, Cell Biol. 97, 1648-1652 (1983).
-
(1983)
J. Cell Biol.
, vol.97
, pp. 1648-1652
-
-
Montesano, R.1
Orci, L.2
Vassalli, P.3
-
10
-
-
0036510605
-
DNAzymes to beta 1 and beta 3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and Matrigel
-
Cieslak, M. et al. DNAzymes to beta 1 and beta 3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and Matrigel, J. Biol. Chem. 277, 6779-6787 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 6779-6787
-
-
Cieslak, M.1
-
11
-
-
0029812609
-
Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)
-
Lee, S. et al. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science 273, 1219-1221 (1996).
-
(1996)
Science
, vol.273
, pp. 1219-1221
-
-
Lee, S.1
-
12
-
-
0019521049
-
A corneal micropocket assay for angiogenesis in the rat eye
-
Fournier, G.A., Lutty, G.A., Watt, S., Fenselau, A. & Patz, A, A corneal micropocket assay for angiogenesis in the rat eye. Invest. Ophthalmol. Vis. Sci. 21, 351-354 (1981).
-
(1981)
Invest. Ophthalmol. Vis. Sci.
, vol.21
, pp. 351-354
-
-
Fournier, G.A.1
Lutty, G.A.2
Watt, S.3
Fenselau, A.4
Patz, A.5
-
13
-
-
0033168947
-
Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA
-
Parry, T.J. et al. Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA. Nucleic Acids Res. 27, 2569-2577 (1999).
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 2569-2577
-
-
Parry, T.J.1
-
14
-
-
0035851218
-
Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis
-
Lowe, H.C, et al. Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis. Circ. Res. 89, 670-677 (2001).
-
(2001)
Circ. Res.
, vol.89
, pp. 670-677
-
-
Lowe, H.C.1
-
15
-
-
0021359304
-
Heparin affinity: Purification of a tumor-derived capillary endothelial cell growth factor
-
Shing, Y. et al. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor, Science 223, 1296-1298 (1984).
-
(1984)
Science
, vol.223
, pp. 1296-1298
-
-
Shing, Y.1
-
16
-
-
0032996518
-
Egr-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2
-
Santiago, F.S., Lowe, H.C., Day, F.L., Chesterman, C,N. & Khachigian, L.M. Egr-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2. Am. J. Pathol. 154, 937-944 (1999).
-
(1999)
Am. J. Pathol.
, vol.154
, pp. 937-944
-
-
Santiago, F.S.1
Lowe, H.C.2
Day, F.L.3
Chesterman, C.N.4
Khachigian, L.M.5
-
17
-
-
0030999316
-
Basic fibroblast growth factor transcriptional autoregulation requires EGR-1
-
Wang, D., Mayo, M.W. & Baldwin, A.S., Jr. Basic fibroblast growth factor transcriptional autoregulation requires EGR-1. Oncogene 14, 2291-2299 (1997).
-
(1997)
Oncogene
, vol.14
, pp. 2291-2299
-
-
Wang, D.1
Mayo, M.W.2
Baldwin A.S., Jr.3
-
18
-
-
0029779351
-
Egr-1 activates basic fibroblast growth factor transcription
-
Biesiada, E., Razandi, M. & Levin, E.R. Egr-1 activates basic fibroblast growth factor transcription. J. Biol. Chem. 271, 18576-18581 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 18576-18581
-
-
Biesiada, E.1
Razandi, M.2
Levin, E.R.3
-
19
-
-
0031774306
-
Tumor growth of FGF or VEGF transfected MCF-7 breast carcinoma cells correlates with density of specific microvessels independent of the transfected angiogenic factor
-
McLeskey, S.W, et al. Tumor growth of FGF or VEGF transfected MCF-7 breast carcinoma cells correlates with density of specific microvessels independent of the transfected angiogenic factor. Am. J. Pathol. 153, 1993-2006 (1998).
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 1993-2006
-
-
McLeskey, S.W.1
-
20
-
-
0029980289
-
Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis
-
McLeskey, S.W. et al. Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis. Breast Cancer Res. Treat. 39, 103-117 (1996).
-
(1996)
Breast Cancer Res. Treat.
, vol.39
, pp. 103-117
-
-
McLeskey, S.W.1
-
21
-
-
0033213955
-
Overexpression of fibroblast growth factor 1 in MCF-7 breast cancer cells facilitates tumor cell dissemination but does not support the development of macrometastases in the lungs or lymph nodes
-
Zhang, L., Kharbanda, S., McLeskey, S.W. & Kern, F.G. Overexpression of fibroblast growth factor 1 in MCF-7 breast cancer cells facilitates tumor cell dissemination but does not support the development of macrometastases in the lungs or lymph nodes. Cancer Res, 59, 5023-5029 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 5023-5029
-
-
Zhang, L.1
Kharbanda, S.2
McLeskey, S.W.3
Kern, F.G.4
-
22
-
-
0029972404
-
Effects of AGM-1470 and pentosan polysulphate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells
-
McLeskey, S.W. et al. Effects of AGM-1470 and pentosan polysulphate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells. Br. J. Cancer 73, 1053-1062 (1996).
-
(1996)
Br. J. Cancer
, vol.73
, pp. 1053-1062
-
-
McLeskey, S.W.1
-
23
-
-
0031974288
-
Both autocrine and paracrine effects of transfected acidic fibroblast growth factor are involved in the estrogen-independent and antiestrogen-resistant growth of MCF-7 breast cancer cells
-
Zhang, L., Kharabanda, S., Hanfelt, J. & Kern, F.G. Both autocrine and paracrine effects of transfected acidic fibroblast growth factor are involved in the estrogen-independent and antiestrogen-resistant growth of MCF-7 breast cancer cells. Cancer Res. 58, 352-361 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 352-361
-
-
Zhang, L.1
Kharabanda, S.2
Hanfelt, J.3
Kern, F.G.4
-
24
-
-
0035266283
-
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
-
Karpanen, T. et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res. 61, 1786-1790 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 1786-1790
-
-
Karpanen, T.1
-
25
-
-
0031039923
-
Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation
-
Gille, J., Swerlick, R.A. & Caughman, S.W. Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation. EMBO J. 16, 750-759 (1997).
-
(1997)
EMBO J.
, vol.16
, pp. 750-759
-
-
Gille, J.1
Swerlick, R.A.2
Caughman, S.W.3
-
26
-
-
0030753430
-
Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression
-
Finkenzeller, G., Sparacio, A., Technau, A., Marme, D. & Siemeister, G. Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression. Oncogene 15, 669-676 (1997).
-
(1997)
Oncogene
, vol.15
, pp. 669-676
-
-
Finkenzeller, G.1
Sparacio, A.2
Technau, A.3
Marme, D.4
Siemeister, G.5
-
27
-
-
0037124333
-
Active immunization against the vascular endothelial growth factor receptor flk1 inhibits tumor angiogenesis and metastasis
-
Li, Y. et al. Active immunization against the vascular endothelial growth factor receptor flk1 inhibits tumor angiogenesis and metastasis. J. Exp. Med. 195, 1575-1584 (2002).
-
(2002)
J. Exp. Med.
, vol.195
, pp. 1575-1584
-
-
Li, Y.1
-
28
-
-
0032698140
-
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
-
Prewett, M. et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res. 59, 5209-5218 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 5209-5218
-
-
Prewett, M.1
-
29
-
-
0033856239
-
Gene transfer of a soluble receptor of VEGF inhibits the growth of experimental eyelid malignant melanoma
-
Shiose, S. et al. Gene transfer of a soluble receptor of VEGF inhibits the growth of experimental eyelid malignant melanoma. Invest. Opthalmol. Vis. Sci. 41, 2395-2403 (2000).
-
(2000)
Invest. Opthalmol. Vis. Sci.
, vol.41
, pp. 2395-2403
-
-
Shiose, S.1
-
30
-
-
0025340141
-
Studies on the role of basic fibroblast growth factor in vivo: Inability of neutralizing antibodies to block tumor growth
-
Dennis, P.A. & Rifkin, D.B. Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth. J Cell. Physiol. 144, 84-98 (1990).
-
(1990)
J. Cell. Physiol.
, vol.144
, pp. 84-98
-
-
Dennis, P.A.1
Rifkin, D.B.2
-
31
-
-
0036021883
-
Anti-tumor angiogenesis therapy using soluble receptors: Enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor
-
Ogawa, T., Takayama, K., Takakura, N., Kitano, S. & Ueno, H. Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor. Cancer Gene Ther. 9, 633-640 (2002).
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 633-640
-
-
Ogawa, T.1
Takayama, K.2
Takakura, N.3
Kitano, S.4
Ueno, H.5
-
32
-
-
0037102369
-
ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
-
Wedge, S.R. et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 62, 4645-4655 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 4645-4655
-
-
Wedge, S.R.1
-
33
-
-
0029121235
-
Angiogenesis: Mechanistic insights, neovascular diseases, and therapeutic prospects
-
Battegay, E.J. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects. J. Mol. Med. 73, 333-346 (1995).
-
(1995)
J. Mol. Med.
, vol.73
, pp. 333-346
-
-
Battegay, E.J.1
-
34
-
-
0033529709
-
Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase
-
Haas, T.L., Stitelman, D., Davis, S.J., Apte, S.S. & Madri, J.A. Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase. J. Biol. Chem. 274, 22679-22685 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 22679-22685
-
-
Haas, T.L.1
Stitelman, D.2
Davis, S.J.3
Apte, S.S.4
Madri, J.A.5
-
35
-
-
0036172369
-
Intratumoral cancer chemotherapy and immunotherapy: Opportunities for nonsystemic preoperative drug delivery
-
Goldberg, E.P., Hadba, A.R., Almond, B.A. & Marotta, J.S. Intratumoral cancer chemotherapy and immunotherapy: opportunities for nonsystemic preoperative drug delivery. J. Pharm. Pharmacol. 54, 159-180 (2002).
-
(2002)
J. Pharm. Pharmacol.
, vol.54
, pp. 159-180
-
-
Goldberg, E.P.1
Hadba, A.R.2
Almond, B.A.3
Marotta, J.S.4
-
36
-
-
0033692912
-
Nuclease-resistant synthetic ribozymes: Developing a new class of therapeutics
-
Usman, N. & Blatt, L.M. Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics. J. Clin. Invest. 106, 1197-1202 (2000).
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1197-1202
-
-
Usman, N.1
Blatt, L.M.2
-
37
-
-
0034069028
-
Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors
-
Pavco, P.A. et al. Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors. Clin. Cancer Res. 6, 2094-2103 (2000).
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2094-2103
-
-
Pavco, P.A.1
-
38
-
-
0035885932
-
Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors
-
Masood, R. et al. Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors. Blood 98, 1904-1913 (2001).
-
(2001)
Blood
, vol.98
, pp. 1904-1913
-
-
Masood, R.1
-
39
-
-
0033396726
-
Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells
-
Herold-Mende, C. et al. Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells. Lab. Invest. 79, 1573-1782 (1999).
-
(1999)
Lab. Invest.
, vol.79
, pp. 1573-1782
-
-
Herold-Mende, C.1
-
40
-
-
0036959644
-
Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration
-
Eyetech. Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina 22, 143-152 (2002).
-
(2002)
Retina
, vol.22
, pp. 143-152
-
-
-
41
-
-
0035997959
-
DNAzymes: Cutting a path to a new class of therapeutics
-
Khachigian, L.M. DNAzymes: cutting a path to a new class of therapeutics. Curr. Opin. Mol. Ther. 4, 119-121 (2002).
-
(2002)
Curr. Opin. Mol. Ther.
, vol.4
, pp. 119-121
-
-
Khachigian, L.M.1
-
42
-
-
0032717640
-
New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth factor injury
-
Santiago, F.S. et al. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth factor injury. Nat. Med. 11, 1264-1269 (1999).
-
(1999)
Nat. Med.
, vol.11
, pp. 1264-1269
-
-
Santiago, F.S.1
-
43
-
-
0037151008
-
c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury: Inhibition by a novel DNAzyme targeting c-Jun
-
Khachigian, L.M., Fahmy, R.G., Zhang, G., Bobryshev, Y.V. & Kaniaros, A. c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury: inhibition by a novel DNAzyme targeting c-Jun. J. Biol. Chem. 277, 22985-22991 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22985-22991
-
-
Khachigian, L.M.1
Fahmy, R.G.2
Zhang, G.3
Bobryshev, Y.V.4
Kaniaros, A.5
-
44
-
-
0035153146
-
Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice
-
Chan, J.C., Duszczyszyn, D.A., Castellino, F.J. & Ploplis, V.A. Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice. Am. J. Pathol. 159, 1681-1688 (2001).
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 1681-1688
-
-
Chan, J.C.1
Duszczyszyn, D.A.2
Castellino, F.J.3
Ploplis, V.A.4
-
45
-
-
0034663948
-
Monocyte tissue factor induction by activation of beta 2-glycoprotein-1-specific T lymphocytes is associated with thrombosis and fetal loss in patients with antiphospholipid antibodies
-
Visvanathan, S., Geczy, C.L., Harmer, J.A. & McNeil, H.P. Monocyte tissue factor induction by activation of beta 2-glycoprotein-1-specific T lymphocytes is associated with thrombosis and fetal loss in patients with antiphospholipid antibodies. J. Immunol. 165, 2258-2262 (2000).
-
(2000)
J. Immunol.
, vol.165
, pp. 2258-2262
-
-
Visvanathan, S.1
Geczy, C.L.2
Harmer, J.A.3
McNeil, H.P.4
|