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Volumn 9, Issue 8, 2003, Pages 1026-1032

Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth

Author keywords

[No Author keywords available]

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; ENZYME; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; MATRIGEL; MESSENGER RNA; RNA CLEAVING PHOSPHODIESTER LINKED DNA BASED ENZYME; TRANSCRIPTION FACTOR EGR 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 0041464740     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm905     Document Type: Article
Times cited : (328)

References (45)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-1186 (1971).
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 0015311426 scopus 로고
    • Anti-angiogenesis: New concept for therapy of solid tumors
    • Folkman, J. Anti-angiogenesis: new concept for therapy of solid tumors. Ann. Surg. 175,409-416 (1972).
    • (1972) Ann. Surg. , vol.175 , pp. 409-416
    • Folkman, J.1
  • 3
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel, R, & Folkman, J. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2, 727-739 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 4
    • 0024281381 scopus 로고
    • A zinc-finger encoding gene corregulated with c-Fos during growth and differentiation and after depolarization
    • Sukhatme, V.P. et al. A zinc-finger encoding gene corregulated with c-Fos during growth and differentiation and after depolarization. Cell 53, 37-43 (1988).
    • (1988) Cell , vol.53 , pp. 37-43
    • Sukhatme, V.P.1
  • 5
    • 0029161198 scopus 로고
    • Early growth response protein 1 (Egr-1): Prototype of a zinc-finger family of transcription factors
    • Gashler, A. & Sukhatme, V. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog, Nucl. Acid Res, 50, 191-224 (1995).
    • (1995) Prog. Nucl. Acid Res. , vol.50 , pp. 191-224
    • Gashler, A.1    Sukhatme, V.2
  • 6
    • 0029996110 scopus 로고    scopus 로고
    • Egr-1-induced endothelial gene expression: A common theme in vascular injury
    • Khachigian, L.M., Lindner, V., Williams, A.J. & Collins, T. Egr-1-induced endothelial gene expression: a common theme in vascular injury, Science 271, 1427-1431 (1996).
    • (1996) Science , vol.271 , pp. 1427-1431
    • Khachigian, L.M.1    Lindner, V.2    Williams, A.J.3    Collins, T.4
  • 7
    • 0030818274 scopus 로고    scopus 로고
    • Inducible expression of Egr-1-dependent genes: A paradigm of transcriptional activation in vascular endothelium
    • Khachigian, L.M. & Collins, T. Inducible expression of Egr-1-dependent genes: a paradigm of transcriptional activation in vascular endothelium. Circ. Res, 81, 457-461 (1997).
    • (1997) Circ. Res. , vol.81 , pp. 457-461
    • Khachigian, L.M.1    Collins, T.2
  • 8
    • 0030898510 scopus 로고    scopus 로고
    • A general purpose RNA-cleaving DNA enzyme
    • Santoro, S.W. & Joyce, G.F. A general purpose RNA-cleaving DNA enzyme. Proc. Natl. Acad. Sci. USA 94, 4262-4266 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4262-4266
    • Santoro, S.W.1    Joyce, G.F.2
  • 9
    • 0021055582 scopus 로고
    • In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices
    • Montesano, R., Orci, L. & Vassalli, P. In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices. J, Cell Biol. 97, 1648-1652 (1983).
    • (1983) J. Cell Biol. , vol.97 , pp. 1648-1652
    • Montesano, R.1    Orci, L.2    Vassalli, P.3
  • 10
    • 0036510605 scopus 로고    scopus 로고
    • DNAzymes to beta 1 and beta 3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and Matrigel
    • Cieslak, M. et al. DNAzymes to beta 1 and beta 3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and Matrigel, J. Biol. Chem. 277, 6779-6787 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 6779-6787
    • Cieslak, M.1
  • 11
    • 0029812609 scopus 로고    scopus 로고
    • Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)
    • Lee, S. et al. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science 273, 1219-1221 (1996).
    • (1996) Science , vol.273 , pp. 1219-1221
    • Lee, S.1
  • 13
    • 0033168947 scopus 로고    scopus 로고
    • Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA
    • Parry, T.J. et al. Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA. Nucleic Acids Res. 27, 2569-2577 (1999).
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2569-2577
    • Parry, T.J.1
  • 14
    • 0035851218 scopus 로고    scopus 로고
    • Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis
    • Lowe, H.C, et al. Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis. Circ. Res. 89, 670-677 (2001).
    • (2001) Circ. Res. , vol.89 , pp. 670-677
    • Lowe, H.C.1
  • 15
    • 0021359304 scopus 로고
    • Heparin affinity: Purification of a tumor-derived capillary endothelial cell growth factor
    • Shing, Y. et al. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor, Science 223, 1296-1298 (1984).
    • (1984) Science , vol.223 , pp. 1296-1298
    • Shing, Y.1
  • 16
    • 0032996518 scopus 로고    scopus 로고
    • Egr-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2
    • Santiago, F.S., Lowe, H.C., Day, F.L., Chesterman, C,N. & Khachigian, L.M. Egr-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2. Am. J. Pathol. 154, 937-944 (1999).
    • (1999) Am. J. Pathol. , vol.154 , pp. 937-944
    • Santiago, F.S.1    Lowe, H.C.2    Day, F.L.3    Chesterman, C.N.4    Khachigian, L.M.5
  • 17
    • 0030999316 scopus 로고    scopus 로고
    • Basic fibroblast growth factor transcriptional autoregulation requires EGR-1
    • Wang, D., Mayo, M.W. & Baldwin, A.S., Jr. Basic fibroblast growth factor transcriptional autoregulation requires EGR-1. Oncogene 14, 2291-2299 (1997).
    • (1997) Oncogene , vol.14 , pp. 2291-2299
    • Wang, D.1    Mayo, M.W.2    Baldwin A.S., Jr.3
  • 18
    • 0029779351 scopus 로고    scopus 로고
    • Egr-1 activates basic fibroblast growth factor transcription
    • Biesiada, E., Razandi, M. & Levin, E.R. Egr-1 activates basic fibroblast growth factor transcription. J. Biol. Chem. 271, 18576-18581 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 18576-18581
    • Biesiada, E.1    Razandi, M.2    Levin, E.R.3
  • 19
    • 0031774306 scopus 로고    scopus 로고
    • Tumor growth of FGF or VEGF transfected MCF-7 breast carcinoma cells correlates with density of specific microvessels independent of the transfected angiogenic factor
    • McLeskey, S.W, et al. Tumor growth of FGF or VEGF transfected MCF-7 breast carcinoma cells correlates with density of specific microvessels independent of the transfected angiogenic factor. Am. J. Pathol. 153, 1993-2006 (1998).
    • (1998) Am. J. Pathol. , vol.153 , pp. 1993-2006
    • McLeskey, S.W.1
  • 20
    • 0029980289 scopus 로고    scopus 로고
    • Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis
    • McLeskey, S.W. et al. Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis. Breast Cancer Res. Treat. 39, 103-117 (1996).
    • (1996) Breast Cancer Res. Treat. , vol.39 , pp. 103-117
    • McLeskey, S.W.1
  • 21
    • 0033213955 scopus 로고    scopus 로고
    • Overexpression of fibroblast growth factor 1 in MCF-7 breast cancer cells facilitates tumor cell dissemination but does not support the development of macrometastases in the lungs or lymph nodes
    • Zhang, L., Kharbanda, S., McLeskey, S.W. & Kern, F.G. Overexpression of fibroblast growth factor 1 in MCF-7 breast cancer cells facilitates tumor cell dissemination but does not support the development of macrometastases in the lungs or lymph nodes. Cancer Res, 59, 5023-5029 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5023-5029
    • Zhang, L.1    Kharbanda, S.2    McLeskey, S.W.3    Kern, F.G.4
  • 22
    • 0029972404 scopus 로고    scopus 로고
    • Effects of AGM-1470 and pentosan polysulphate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells
    • McLeskey, S.W. et al. Effects of AGM-1470 and pentosan polysulphate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells. Br. J. Cancer 73, 1053-1062 (1996).
    • (1996) Br. J. Cancer , vol.73 , pp. 1053-1062
    • McLeskey, S.W.1
  • 23
    • 0031974288 scopus 로고    scopus 로고
    • Both autocrine and paracrine effects of transfected acidic fibroblast growth factor are involved in the estrogen-independent and antiestrogen-resistant growth of MCF-7 breast cancer cells
    • Zhang, L., Kharabanda, S., Hanfelt, J. & Kern, F.G. Both autocrine and paracrine effects of transfected acidic fibroblast growth factor are involved in the estrogen-independent and antiestrogen-resistant growth of MCF-7 breast cancer cells. Cancer Res. 58, 352-361 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 352-361
    • Zhang, L.1    Kharabanda, S.2    Hanfelt, J.3    Kern, F.G.4
  • 24
    • 0035266283 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
    • Karpanen, T. et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res. 61, 1786-1790 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 1786-1790
    • Karpanen, T.1
  • 25
    • 0031039923 scopus 로고    scopus 로고
    • Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation
    • Gille, J., Swerlick, R.A. & Caughman, S.W. Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation. EMBO J. 16, 750-759 (1997).
    • (1997) EMBO J. , vol.16 , pp. 750-759
    • Gille, J.1    Swerlick, R.A.2    Caughman, S.W.3
  • 26
    • 0030753430 scopus 로고    scopus 로고
    • Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression
    • Finkenzeller, G., Sparacio, A., Technau, A., Marme, D. & Siemeister, G. Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression. Oncogene 15, 669-676 (1997).
    • (1997) Oncogene , vol.15 , pp. 669-676
    • Finkenzeller, G.1    Sparacio, A.2    Technau, A.3    Marme, D.4    Siemeister, G.5
  • 27
    • 0037124333 scopus 로고    scopus 로고
    • Active immunization against the vascular endothelial growth factor receptor flk1 inhibits tumor angiogenesis and metastasis
    • Li, Y. et al. Active immunization against the vascular endothelial growth factor receptor flk1 inhibits tumor angiogenesis and metastasis. J. Exp. Med. 195, 1575-1584 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1575-1584
    • Li, Y.1
  • 28
    • 0032698140 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
    • Prewett, M. et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res. 59, 5209-5218 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5209-5218
    • Prewett, M.1
  • 29
    • 0033856239 scopus 로고    scopus 로고
    • Gene transfer of a soluble receptor of VEGF inhibits the growth of experimental eyelid malignant melanoma
    • Shiose, S. et al. Gene transfer of a soluble receptor of VEGF inhibits the growth of experimental eyelid malignant melanoma. Invest. Opthalmol. Vis. Sci. 41, 2395-2403 (2000).
    • (2000) Invest. Opthalmol. Vis. Sci. , vol.41 , pp. 2395-2403
    • Shiose, S.1
  • 30
    • 0025340141 scopus 로고
    • Studies on the role of basic fibroblast growth factor in vivo: Inability of neutralizing antibodies to block tumor growth
    • Dennis, P.A. & Rifkin, D.B. Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth. J Cell. Physiol. 144, 84-98 (1990).
    • (1990) J. Cell. Physiol. , vol.144 , pp. 84-98
    • Dennis, P.A.1    Rifkin, D.B.2
  • 31
    • 0036021883 scopus 로고    scopus 로고
    • Anti-tumor angiogenesis therapy using soluble receptors: Enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor
    • Ogawa, T., Takayama, K., Takakura, N., Kitano, S. & Ueno, H. Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor. Cancer Gene Ther. 9, 633-640 (2002).
    • (2002) Cancer Gene Ther. , vol.9 , pp. 633-640
    • Ogawa, T.1    Takayama, K.2    Takakura, N.3    Kitano, S.4    Ueno, H.5
  • 32
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge, S.R. et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 62, 4645-4655 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 4645-4655
    • Wedge, S.R.1
  • 33
    • 0029121235 scopus 로고
    • Angiogenesis: Mechanistic insights, neovascular diseases, and therapeutic prospects
    • Battegay, E.J. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects. J. Mol. Med. 73, 333-346 (1995).
    • (1995) J. Mol. Med. , vol.73 , pp. 333-346
    • Battegay, E.J.1
  • 34
    • 0033529709 scopus 로고    scopus 로고
    • Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase
    • Haas, T.L., Stitelman, D., Davis, S.J., Apte, S.S. & Madri, J.A. Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase. J. Biol. Chem. 274, 22679-22685 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 22679-22685
    • Haas, T.L.1    Stitelman, D.2    Davis, S.J.3    Apte, S.S.4    Madri, J.A.5
  • 35
    • 0036172369 scopus 로고    scopus 로고
    • Intratumoral cancer chemotherapy and immunotherapy: Opportunities for nonsystemic preoperative drug delivery
    • Goldberg, E.P., Hadba, A.R., Almond, B.A. & Marotta, J.S. Intratumoral cancer chemotherapy and immunotherapy: opportunities for nonsystemic preoperative drug delivery. J. Pharm. Pharmacol. 54, 159-180 (2002).
    • (2002) J. Pharm. Pharmacol. , vol.54 , pp. 159-180
    • Goldberg, E.P.1    Hadba, A.R.2    Almond, B.A.3    Marotta, J.S.4
  • 36
    • 0033692912 scopus 로고    scopus 로고
    • Nuclease-resistant synthetic ribozymes: Developing a new class of therapeutics
    • Usman, N. & Blatt, L.M. Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics. J. Clin. Invest. 106, 1197-1202 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 1197-1202
    • Usman, N.1    Blatt, L.M.2
  • 37
    • 0034069028 scopus 로고    scopus 로고
    • Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors
    • Pavco, P.A. et al. Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors. Clin. Cancer Res. 6, 2094-2103 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2094-2103
    • Pavco, P.A.1
  • 38
    • 0035885932 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors
    • Masood, R. et al. Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors. Blood 98, 1904-1913 (2001).
    • (2001) Blood , vol.98 , pp. 1904-1913
    • Masood, R.1
  • 39
    • 0033396726 scopus 로고    scopus 로고
    • Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells
    • Herold-Mende, C. et al. Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells. Lab. Invest. 79, 1573-1782 (1999).
    • (1999) Lab. Invest. , vol.79 , pp. 1573-1782
    • Herold-Mende, C.1
  • 40
    • 0036959644 scopus 로고    scopus 로고
    • Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration
    • Eyetech. Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina 22, 143-152 (2002).
    • (2002) Retina , vol.22 , pp. 143-152
  • 41
    • 0035997959 scopus 로고    scopus 로고
    • DNAzymes: Cutting a path to a new class of therapeutics
    • Khachigian, L.M. DNAzymes: cutting a path to a new class of therapeutics. Curr. Opin. Mol. Ther. 4, 119-121 (2002).
    • (2002) Curr. Opin. Mol. Ther. , vol.4 , pp. 119-121
    • Khachigian, L.M.1
  • 42
    • 0032717640 scopus 로고    scopus 로고
    • New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth factor injury
    • Santiago, F.S. et al. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth factor injury. Nat. Med. 11, 1264-1269 (1999).
    • (1999) Nat. Med. , vol.11 , pp. 1264-1269
    • Santiago, F.S.1
  • 43
    • 0037151008 scopus 로고    scopus 로고
    • c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury: Inhibition by a novel DNAzyme targeting c-Jun
    • Khachigian, L.M., Fahmy, R.G., Zhang, G., Bobryshev, Y.V. & Kaniaros, A. c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury: inhibition by a novel DNAzyme targeting c-Jun. J. Biol. Chem. 277, 22985-22991 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 22985-22991
    • Khachigian, L.M.1    Fahmy, R.G.2    Zhang, G.3    Bobryshev, Y.V.4    Kaniaros, A.5
  • 44
    • 0035153146 scopus 로고    scopus 로고
    • Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice
    • Chan, J.C., Duszczyszyn, D.A., Castellino, F.J. & Ploplis, V.A. Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice. Am. J. Pathol. 159, 1681-1688 (2001).
    • (2001) Am. J. Pathol. , vol.159 , pp. 1681-1688
    • Chan, J.C.1    Duszczyszyn, D.A.2    Castellino, F.J.3    Ploplis, V.A.4
  • 45
    • 0034663948 scopus 로고    scopus 로고
    • Monocyte tissue factor induction by activation of beta 2-glycoprotein-1-specific T lymphocytes is associated with thrombosis and fetal loss in patients with antiphospholipid antibodies
    • Visvanathan, S., Geczy, C.L., Harmer, J.A. & McNeil, H.P. Monocyte tissue factor induction by activation of beta 2-glycoprotein-1-specific T lymphocytes is associated with thrombosis and fetal loss in patients with antiphospholipid antibodies. J. Immunol. 165, 2258-2262 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 2258-2262
    • Visvanathan, S.1    Geczy, C.L.2    Harmer, J.A.3    McNeil, H.P.4


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