Tracing sequence diversity change of RNA-cleaving deoxyribozymes under increasing selection pressure during in vitro selection

Biochemistry

Volumn 43, Issue 30, 2004, Pages 9695-9707

  Schlosser, Kenny ^a   Li, Yingfu ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL REACTIONS; DNA; ENZYMES; PRESSURE EFFECTS; RNA;

CATALYTIC SEQUENCE; IN VITRO SELECTION; RNA CLEAVAGE;

BIOCHEMISTRY;

DEOXYRIBOZYME; DNA; RNA CLEAVING DEOXYRIBOZYME; UNCLASSIFIED DRUG;

ARTICLE; DNA LIBRARY; DNA SEQUENCE; IN VITRO SELECTION; METHODOLOGY; MOLECULAR CLONING; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROBABILITY; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; REACTION TIME; RNA CLEAVAGE; SELECTION PRESSURE; SEQUENCE ANALYSIS; SEQUENCE DIVERSITY;

BASE SEQUENCE; CATIONS, DIVALENT; COENZYMES; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA PRIMERS; DNA, CATALYTIC; DNA-DIRECTED RNA POLYMERASES; GENE LIBRARY; GENETIC ENGINEERING; HYDROLYSIS; METALS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTATION; RNA; SEQUENCE ANALYSIS, DNA; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

EID: 3342955521     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049757j     Document Type: Article

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