In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy

Journal of the American Chemical Society

Volumn 130, Issue 29, 2008, Pages 9268-9281

  Cellitti, Susan E ^a   Jones, David H ^a   Lagpacan, Leanna ^a   Hao, Xueshi ^a   Zhang, Qiong ^a   Hu, Huiyong ^a   Brittain, Scott M ^a   Brinker, Achim ^a   Caldwell, Jeremy ^a   Bursulaya, Badry ^a   Spraggon, Glen ^a   Brock, Ansgar ^a   Ryu, Youngha ^b   Uno, Tetsuo ^a   Schultz, Peter G ^a,b   Geierstanger, Bernhard H ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; AMINATION; AMINES; AMINO ACIDS; ATOMS; BIOCHEMISTRY; HEALTH; MAGNETIC FIELDS; MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE; ORGANIC ACIDS; RESONANCE;

2-AMINO; IN-VIVO; LIGAND BINDING; MAGNETIC (CE); N MR STUDIES; PROPANOIC ACIDS; RESONANCE SPECTROSCOPY; SPECTRA (CO); SYNTHETASE;

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

2 AMINO 3 [4 (TRIFLUOROMETHOXY)PHENYL]PROPANOIC ACID; AMINO ACID; FATTY ACID SYNTHASE; PROPIONIC ACID DERIVATIVE; PROTEIN; TRANSFER RNA; TYROSINE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIUM CULTURE; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CODON; CONFORMATIONAL TRANSITION; ESCHERICHIA COLI; FLUORINE NUCLEAR MAGNETIC RESONANCE; LIGAND BINDING; MOLECULAR PROBE; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMID; PROTEIN ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE;

AMINO ACYL-TRNA SYNTHETASES; CARBON ISOTOPES; ESCHERICHIA COLI; FATTY ACID SYNTHETASE COMPLEX; ISOTOPE LABELING; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHENYLALANINE; PHENYLPROPIONATES; PLASMIDS; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; TYROSINE;

EID: 47749109536     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja801602q     Document Type: Article

References (53)

1. Wuthrich, K. Nat. Struct. Biol. 1998, 5, 492-495.
2. Mittermaier, A.; Kay, L. E. Science 2006, 312, 224-228.
3. Tugarinov, V.; Hwang, P. M.; Kay, L. E. Annu. Rev. Biochem. 2004, 73, 107-146.
4. Muchmore, D. C.; McIntosh, L. P.; Russell, C. B.; Anderson, D. E.; Dahlquist, F. W. Methods Enzymol. 1989, 177, 44-73.
5. Gerig, J. T. Prog. Nucl. Magn. Reson. Spectrosc. 1994, 26, 293-370.
6. Frieden, C.; Hoeltzli, S. D.; Bann, J. G. Methods Enzymol. 2004, 380, 400-415.
7. Danielson, M. A.; Falke, J. J. Annu. Rev. Biophys. Biomol. Struct. 1996, 25, 163-195.
8. Gakh, Y. G.; Gakh, A. A.; Gronenborn, A. M. Magn. Reson. Chem. 2000, 38, 551-558.
9. Kainosho, M.; Torizawa, T.; Iwashita, Y.; Terauchi, T.; Mei Ono, A.; Guntert, P. Nature 2006, 440, 52-57.
10. Tugarinov, V.; Kay, L. E. ChemBioChem 2005, 6, 1567-1577.
11. Gardner, K. H.; Rosen, M. K.; Kay, L. E. Biochemistry 1997, 36, 1389-1401.
12. Wang, L.; Xie, J.; Schultz, P. G. Annu. Rev. Biophys. Biomol. Struct 2006, 35, 225-249.
13. Ryu, Y.; Schultz, P. G. Nat. Methods 2006, 3, 263-265.
14. Wang, L.; Schultz, P. G. Chem. Biol. 2001, 3, 883-890.
15. Xie, J.; Schultz, P. G. Nat. Rev. Mol. Cell Biol. 2006, 7, 775-782.
16. Xie, J.; Schultz, P. G. Curr. Opin. Chem. Biol. 2005, 9, 548-554.
17. Xie, J.; Schultz, P. G. Methods 2005, 36, 227-238.
18. Liu, W.; Brock, A.; Chen, S.; Chen, S.; Schultz, P. G. Nat. Methods 2007, 4, 239-244.
19. Deiters, A.; Geierstanger, B. H.; Schultz, P. G. ChemBioChem 2005, 6, 55-58.
20. Hajduk, P. J.; Mack, J. C.; Olejniczak, E. T.; Park, C.; Dandliker, P. J.; Beutel, B. A. J. Am. Chem. Soc. 2004, 126, 2390-2398.
21. Skrynnikov, N. R.; Mulder, F. A. A.; Hon, B.; Dahlquist, F. W.; Kay, L. E. J. Am. Chem. Soc. 2001, 123, 4556-4566.
22. Jackson, J. C.; Hammill, J. T.; Mehl, R. A. J. Am. Chem. Soc. 2007, 129, 1160-1166.
23. Deiters, A.; Groff, D.; Ryu, Y.; Xie, J.; Schultz, P. G. Angew. Chem., Int. Ed. 2006, 45, 2728-2731.
24. Jayakumar, A.; Tai, M. H.; Huang, W. Y.; al-Feel, W.; Hsu, M.; Abu-Elheiga, L.; Chirala, S. S.; Wakil, S. J. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 8695-9.
25. White, S. W.; Zheng, J.; Zhang, Y. M.; Rock, C. H. Annu. Rev. Biochem. 2005, 74, 791-831.
26. Kuhajda, F. P. Cancer Res. 2006, 66, 5977-5980.
27. Ronnett, G. V.; Kleman, A. M.; Kim, E. K.; Landree, L. E.; Tu, Y. Obesity 2006, 14 (14, Suppl 5), 201S-207S.
28. Kridel, S. J.; Axelrod, F.; Rozenkrantz, N.; Smith, J. W. Cancer Res. 2004, 64, 2070-2075.
29. Knowles, L. M.; Axelrod, F.; Browne, C. D.; Smith, J. W. J. Biol. Chem. 2004, 279, 30540-30545.
30. Pemble, C. W.; Johnson, L. C.; Kridel, S. J.; Lowther, W. T. Nat. Struct. Mol. Biol. 2007, 14, 704-709.
31. Klock, H. E.; Koesema, E. J.; Knuth, M. W.; Lesley, S. A. Proteins 2008, 71, 982-994.
32. Chakravarty, B.; Gu, Z.; Chirala, S. S.; Wakil, S. J.; Quiocho, F. A. Proc. Nat. Acad. Sci. U.S.A. 2004, 101, 15567-15572.
33. Brown, C. M.; Stockwell, P. A.; Trotman, C. N.; Tate, W. P. Nucleic Acids Res. 1990, 18, 6339-6345.
34. Wang, L.; Brock, A.; Herberich, B.; Schultz, P. G. Science 2001, 292, 498-500.
35. Schultz, K. C.; Supekova, L.; Ryu, Y. H.; Xie, J. M.; Perera, R.; Schultz, P. G. J. Am. Chem. Soc. 2006, 128, 13984-13985.
36. Wang, L.; Zhang, Z.; Brock, A.; Schultz, P. G. Proc. Natl. Acad. Sei. U.S.A. 2003, 100, 56-61.
37. Michnick, S. W.; Rosen, M. K.; Wandless, T. J.; Karplus, M.; Schreiber, S. L. Science 1991, 252, 836-839.
38. Chen, S.; Schultz, P. G.; Brock, A. J. Mol. Biol. 2007, 371, 112-122.
39. Davis, A. L.; Keeler, J.; Laue, E. D.; Moskau, D. J. Magn. Reson. 1992, 98, 207-216.
40. Mori, S.; Abeygunawardana, C.; Johnson, M. O.; Vanzijl, P. C. M. J. Magn. Reson. Series B 1995, 108, 94-98.
41. Bodanzky, N.; Bodanzky, A. The Practice of Peptide Synthesis, 2nd ed.; Springer Verlag: Berlin-Heidelberg, 1994.
42. Budisa, N.; Pipitone, O.; Siwanowicz, I.; Rubini, M.; Pal, P. P.; Holak, T. A.; Gelmi, M. L. Chem. Biodivers. 2004, 1, 1465-1475.
43. Kobayashi, T.; Nureki, O.; Ishitani, R.; Yaremchuk, A.; Tukalo, M.; Cusack, S.; Sakamoto, K.; Yokoyama, S. Nat. Struct. Biol. 2003, 10, 425-432.
44. Alper, P. B.; Hung, S. C.; Wong, C. H. Tetrahedron Lett. 1996, 37, 6029-6032.
45. Kay, L. E.; Bull, T. E.; Nicholson, L. K.; Griesinger, C.; Schwalbe, H.; Bax, A.; Torchia, D. A. J. Magn. Reson. 1992, 100, 538-558.
46. Kay, L. E.; Bull, T. E.; Nicholson, L. K.; Griesinger, C.; Schwalbe, H.; Bax, A.; Torchia, D. A. J. Magn. Reson. Series A 1994, 111, 231-232.
47. Bai, P.; Luo, L.; Peng, Z. Y. Biochemistry 2000, 39, 372-380.
48. Lee, K. H.; Lee, H. Y.; Slutsky, M. M.; Anderson, J. T.; Marsh, E. N. Biochemistry 2004, 43, 16277-16284.
49. Zhang, Y.; Wang, L.; Schultz, P. G.; Wilson, I. A. Protein Sci. 2005, 14, 1340-1349.
50. Santoro, S. W.; Wang, L.; Herberich, B.; King, D. S.; Schultz, P. G. Nat. Biotechnol. 2002, 20, 1044-1048.
51. Gardner, K. H.; Kay, L. E. Annu. Rev. Biophys. Biomol. Struct. 1998, 27, 357-406.
52. Wu, N.; Deiters, A.; Cropp, T. A.; King, D.; Schultz, P. G. J. Am. Chem. Soc. 2004, 126, 14306-14307.
53. Lemke, E. A.; Summerer, D.; Geierstanger, B. H.; Brittain, S. M.; Schultz, P. G. Nat. Chem. Biol. 2007, 3, 769-772.