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Volumn 77, Issue 12, 1996, Pages 2921-2929

A novel neutralization epitope on the 'thumb' subdomain of human immunodeficiency virus type 1 reverse transcriptase revealed by a monoclonal antibody

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ANTIBODY; EPITOPE; MONOCLONAL ANTIBODY; RNA DIRECTED DNA POLYMERASE; VIRUS ANTIGEN; VIRUS ENZYME;

EID: 8044223401     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-77-12-2921     Document Type: Article
Times cited : (11)

References (45)
  • 1
    • 0024324362 scopus 로고
    • Substrate binding in human immunodeficiency virus reverse transcriptase: An analysis of pyridoxal 5′-phosphate sensitivity and identification of lysine 263 in the substrate-binding domain
    • Basu, A., Tirumalai, R. S. & Modak, M. J. (1989). Substrate binding in human immunodeficiency virus reverse transcriptase: an analysis of pyridoxal 5′-phosphate sensitivity and identification of lysine 263 in the substrate-binding domain. Journal of Biological Chemistry 264, 8746-8752.
    • (1989) Journal of Biological Chemistry , vol.264 , pp. 8746-8752
    • Basu, A.1    Tirumalai, R.S.2    Modak, M.J.3
  • 2
    • 0027993294 scopus 로고
    • Structure/ function studies of human immunodeficiency virus type 1 reverse transcriptase: Alanine scanning mutagenesis of an α-helix on the thumb subdomain
    • Beard, W. A., Stahl, S. J., Kim, H.-R., Bebenek, K., Kumar, A., Strub, M.-P., Becerra, S. P., Kunkel, T. A. & Wilson, S. H. (1994). Structure/ function studies of human immunodeficiency virus type 1 reverse transcriptase: alanine scanning mutagenesis of an α-helix on the thumb subdomain. Journal of Biological Chemistry 269, 28091-28097.
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 28091-28097
    • Beard, W.A.1    Stahl, S.J.2    Kim, H.-R.3    Bebenek, K.4    Kumar, A.5    Strub, M.-P.6    Becerra, S.P.7    Kunkel, T.A.8    Wilson, S.H.9
  • 3
    • 0028341306 scopus 로고
    • Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutant does not
    • Boyer, P. L., Tantillo, C., Jacobo-Molina, A., Nanni, R. G., Ding, J., Arnold, E. & Hughes, S. H. (1994). Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutant does not. Proceedings of the National Academy of Sciences, USA 91, 4882-4886.
    • (1994) Proceedings of the National Academy of Sciences, USA , vol.91 , pp. 4882-4886
    • Boyer, P.L.1    Tantillo, C.2    Jacobo-Molina, A.3    Nanni, R.G.4    Ding, J.5    Arnold, E.6    Hughes, S.H.7
  • 4
    • 0026523623 scopus 로고
    • HIV inhibitors targeted at the reverse transcriptase
    • De Clercq, E. (1992). HIV inhibitors targeted at the reverse transcriptase. AIDS Research and Human Retroviruses 8, 119-134.
    • (1992) AIDS Research and Human Retroviruses , vol.8 , pp. 119-134
    • De Clercq, E.1
  • 6
    • 0028924567 scopus 로고
    • Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
    • Esnouf, R., Ren, J., Ross, C., Jones, Y., Stammers, D. & Stuart, D. (1995). Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Nature Structural Biology 2, 303-308.
    • (1995) Nature Structural Biology , vol.2 , pp. 303-308
    • Esnouf, R.1    Ren, J.2    Ross, C.3    Jones, Y.4    Stammers, D.5    Stuart, D.6
  • 7
    • 0002747447 scopus 로고
    • A non-label technology for real-time biospecific interaction analysis
    • New York: Academic Press
    • Fagerstam, L. (1991). A non-label technology for real-time biospecific interaction analysis. In Techniques in Protein Chemistry II, pp. 65-71. New York: Academic Press.
    • (1991) Techniques in Protein Chemistry II , pp. 65-71
    • Fagerstam, L.1
  • 12
    • 0023673620 scopus 로고
    • Identification and characterization of HIV-specific RNase H by monoclonal antibody
    • Hansen, J., Schulze, T., Mellert, W. & Moeling, K. (1988). Identification and characterization of HIV-specific RNase H by monoclonal antibody. EMBO Journal 7, 239-243.
    • (1988) EMBO Journal , vol.7 , pp. 239-243
    • Hansen, J.1    Schulze, T.2    Mellert, W.3    Moeling, K.4
  • 13
    • 0343450843 scopus 로고
    • Monoclonal antibodies to enzymes
    • Edited by R. H. Kennett, K. B. Bechtol & T. J. McKearn. New York: Plenum Press
    • Harris, H. (1984). Monoclonal antibodies to enzymes. In Monoclonal Antibodies and Functional Cell Lines: Progress and Application, pp. 33-65. Edited by R. H. Kennett, K. B. Bechtol & T. J. McKearn. New York: Plenum Press.
    • (1984) Monoclonal Antibodies and Functional Cell Lines: Progress and Application , pp. 33-65
    • Harris, H.1
  • 14
    • 0028090098 scopus 로고
    • The 'helix clamp' in HIV-1 reverse transcriptase: A new nucleic acid binding motif common in nucleic acid polymerases
    • Hermann, T., Meier, T., Götte, M. & Heumann, H. (1994). The 'helix clamp' in HIV-1 reverse transcriptase: a new nucleic acid binding motif common in nucleic acid polymerases. Nucleic Acids Research 22, 4625-4633.
    • (1994) Nucleic Acids Research , vol.22 , pp. 4625-4633
    • Hermann, T.1    Meier, T.2    Götte, M.3    Heumann, H.4
  • 15
    • 0022344161 scopus 로고
    • Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions
    • Hoffman, A. D., Banapour, B. & Levy, J. A. (1985). Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions. Virology 147, 326-335.
    • (1985) Virology , vol.147 , pp. 326-335
    • Hoffman, A.D.1    Banapour, B.2    Levy, J.A.3
  • 17
    • 0026094405 scopus 로고
    • Role of the gag and pol genes of human immunodeficiency virus in the morphogenesis and maturation of retrovirus-like particles expressed by recombinant vaccinia virus: An ultrastructural study
    • Hoshikawa, N., Kojima, A., Yasuda, A., Takayashiki, E., Masuko, S., Chiba, J., Sata, T. & Kurata, T. (1991). Role of the gag and pol genes of human immunodeficiency virus in the morphogenesis and maturation of retrovirus-like particles expressed by recombinant vaccinia virus: an ultrastructural study. Journal of General Virology 72, 2509-2517.
    • (1991) Journal of General Virology , vol.72 , pp. 2509-2517
    • Hoshikawa, N.1    Kojima, A.2    Yasuda, A.3    Takayashiki, E.4    Masuko, S.5    Chiba, J.6    Sata, T.7    Kurata, T.8
  • 18
    • 0025775810 scopus 로고
    • HIV reverse transcriptase structure-function relationships
    • Jacobo-Molina, A. & Arnold, E. (1991). HIV reverse transcriptase structure-function relationships. Biochemistry 30, 6351-6361.
    • (1991) Biochemistry , vol.30 , pp. 6351-6361
    • Jacobo-Molina, A.1    Arnold, E.2
  • 20
    • 0018784438 scopus 로고
    • Surface and inside volumes in globular proteins
    • Janin, J. (1979). Surface and inside volumes in globular proteins. Nature 277. 491-492.
    • (1979) Nature , vol.277 , pp. 491-492
    • Janin, J.1
  • 21
    • 0025944815 scopus 로고
    • Immobilization of proteins to a carboxymethyldextran modified gold surface for biospecific interaction analysis in surface plasmon resonance
    • Johnsson, B., Lofas, S. & Lindquist, G. (1991). Immobilization of proteins to a carboxymethyldextran modified gold surface for biospecific interaction analysis in surface plasmon resonance. Analytical Biochemistry 198, 268-277.
    • (1991) Analytical Biochemistry , vol.198 , pp. 268-277
    • Johnsson, B.1    Lofas, S.2    Lindquist, G.3
  • 22
    • 0026693137 scopus 로고
    • Crystal structure at 3·5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor
    • Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A. & Steitz, T. A. (1992). Crystal structure at 3·5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256, 1783-1790.
    • (1992) Science , vol.256 , pp. 1783-1790
    • Kohlstaedt, L.A.1    Wang, J.2    Friedman, J.M.3    Rice, P.A.4    Steitz, T.A.5
  • 23
    • 0003153607 scopus 로고
    • The structure of HIV-1 reverse transcriptase
    • Edited by A. M. Skalka & S. P. Goff. New York: Cold Spring Harbor Laboratory
    • Kohlstaedt, L. A., Wang, J., Rice, P. A., Friedman, J. M. & Steitz, T. A. (1993). The structure of HIV-1 reverse transcriptase. In Reverse Transcriptase, pp. 223-249. Edited by A. M. Skalka & S. P. Goff. New York: Cold Spring Harbor Laboratory.
    • (1993) Reverse Transcriptase , pp. 223-249
    • Kohlstaedt, L.A.1    Wang, J.2    Rice, P.A.3    Friedman, J.M.4    Steitz, T.A.5
  • 24
    • 0000456849 scopus 로고
    • Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance
    • Edited by A. M. Skalka & S. P. Goff. New York: Cold Spring Harbor Laboratory
    • Larder, B. A. (1993). Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance. In Reverse Transcriptase, pp. 205-222. Edited by A. M. Skalka & S. P. Goff. New York: Cold Spring Harbor Laboratory.
    • (1993) Reverse Transcriptase , pp. 205-222
    • Larder, B.A.1
  • 25
    • 0028323494 scopus 로고
    • Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase
    • Larder, B. A. (1994). Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase. Journal of General Virology 75, 951-957.
    • (1994) Journal of General Virology , vol.75 , pp. 951-957
    • Larder, B.A.1
  • 26
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-I reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder, B. A. & Kemp, S. D. (1989). Multiple mutations in HIV-I reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 246, 1155-1158.
    • (1989) Science , vol.246 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 27
    • 0023251351 scopus 로고
    • Site-specific mutagenesis of AIDS virus reverse transcriptase
    • Larder, B. A., Purifoy, D. J. M., Powell, K. L. & Darby, G. (1987). Site-specific mutagenesis of AIDS virus reverse transcriptase. Nature 327, 716-717.
    • (1987) Nature , vol.327 , pp. 716-717
    • Larder, B.A.1    Purifoy, D.J.M.2    Powell, K.L.3    Darby, G.4
  • 28
    • 0027461280 scopus 로고
    • Generation and characterization of murine monoclonal antibodies reactive against N-terminal and other regions of HIV-1 reverse transcriptase
    • Li, X., Amandoron, E., Wainberg, M. A. & Parniak, M. A. (1993). Generation and characterization of murine monoclonal antibodies reactive against N-terminal and other regions of HIV-1 reverse transcriptase. Journal of Medical Virology 39, 251-259.
    • (1993) Journal of Medical Virology , vol.39 , pp. 251-259
    • Li, X.1    Amandoron, E.2    Wainberg, M.A.3    Parniak, M.A.4
  • 29
    • 0023775755 scopus 로고
    • Studies on the mechanism of human immunodeficiency virus reverse transcriptase: Steady-state kinetics, processivity, and polynucleotide inhibition
    • Majumdar, C., Abbots, J., Broader, S. & Wilson, S. H. (1988). Studies on the mechanism of human immunodeficiency virus reverse transcriptase: steady-state kinetics, processivity, and polynucleotide inhibition. Journal of Biological Chemistry 263, 15657-15665.
    • (1988) Journal of Biological Chemistry , vol.263 , pp. 15657-15665
    • Majumdar, C.1    Abbots, J.2    Broader, S.3    Wilson, S.H.4
  • 30
    • 0344267099 scopus 로고
    • Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance
    • Edited by G. Myers, B. Korber, S. Wain-Hobson, K.-T. Jeang, L. E. Henderson & G. N. Pavlakis. Los Alamos, N. Mex.: Los Alamos National Laboratory
    • Mellors, J. W., Larder, B. A. & Schinazi, R. F. (1994). Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance. In Human Retroviruses and AIDS DATABASE 94, pp. III 93-106. Edited by G. Myers, B. Korber, S. Wain-Hobson, K.-T. Jeang, L. E. Henderson & G. N. Pavlakis. Los Alamos, N. Mex.: Los Alamos National Laboratory.
    • (1994) Human Retroviruses and AIDS DATABASE 94
    • Mellors, J.W.1    Larder, B.A.2    Schinazi, R.F.3
  • 31
    • 0025186450 scopus 로고
    • Molecular targets for AIDS therapy
    • Mitsuya, H., Yarchoan, R. & Broder, S. (1990). Molecular targets for AIDS therapy. Science 249, 1533-1544.
    • (1990) Science , vol.249 , pp. 1533-1544
    • Mitsuya, H.1    Yarchoan, R.2    Broder, S.3
  • 32
    • 0025856362 scopus 로고
    • Immunological characterization of the human immunodeficiency virus type 1 reverse transcriptase protein by the use of monoclonal antibodies
    • Örvell, C., Unge, T., Bhikhabhai, R., Bäckbro, K., Rudén, U., Strandberg, B., Wahren, B. & Fenyö, E. M. (1991). Immunological characterization of the human immunodeficiency virus type 1 reverse transcriptase protein by the use of monoclonal antibodies. Journal of General Virology 72, 1913-1918.
    • (1991) Journal of General Virology , vol.72 , pp. 1913-1918
    • Örvell, C.1    Unge, T.2    Bhikhabhai, R.3    Bäckbro, K.4    Rudén, U.5    Strandberg, B.6    Wahren, B.7    Fenyö, E.M.8
  • 33
    • 0026735812 scopus 로고
    • Human immunodeficiency virus reverse transcriptase: Steady-state and pre-steady-state kinetics of nucleotide incorporation
    • Reardon, J. E. (1992). Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation. Biochemistry 31, 4473-4479.
    • (1992) Biochemistry , vol.31 , pp. 4473-4479
    • Reardon, J.E.1
  • 34
    • 0025785370 scopus 로고
    • Human immunodeficiency virus reverse transcriptase: Effect of primer length on template-primer binding
    • Reardon, J. E., Furfine, E. S. & Cheng, N. (1991). Human immunodeficiency virus reverse transcriptase: effect of primer length on template-primer binding. Journal of Biological Chemistry 266, 14128-14134.
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 14128-14134
    • Reardon, J.E.1    Furfine, E.S.2    Cheng, N.3
  • 36
    • 0026647870 scopus 로고
    • Structure-function relationships of HIV-1 reverse transcriptase determined using monoclonal antibodies: Interaction with a possible deoxynucleoside triphosphate binding domain
    • Restle, T., Pawlita, M., Sczakiel, G., Müller, B. & Goody, R. S. (1992). Structure-function relationships of HIV-1 reverse transcriptase determined using monoclonal antibodies: interaction with a possible deoxynucleoside triphosphate binding domain. Journal of Biological Chemistry 267, 14654-14661.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 14654-14661
    • Restle, T.1    Pawlita, M.2    Sczakiel, G.3    Müller, B.4    Goody, R.S.5
  • 38
    • 0025110162 scopus 로고
    • Overproduction of human immunodeficiency virus type I reverse transcriptase in Escherichia coli and purification of the enzyme
    • Saitoh, A., Iwasaki, H., Nakata, A., Adachi, A. & Shinagawa, H. (1990). Overproduction of human immunodeficiency virus type I reverse transcriptase in Escherichia coli and purification of the enzyme. Microbiology and Immunology 34, 509-521.
    • (1990) Microbiology and Immunology , vol.34 , pp. 509-521
    • Saitoh, A.1    Iwasaki, H.2    Nakata, A.3    Adachi, A.4    Shinagawa, H.5
  • 40
    • 0026153423 scopus 로고
    • Quantitative determination of surface concentration of protein with surface plasmon resonance by using radiolabeled proteins
    • Stenberg, E., Persson, B., Roos, H. & Urbaniczky, C. (1991). Quantitative determination of surface concentration of protein with surface plasmon resonance by using radiolabeled proteins. Journal of Colloid Interface Science 143, 513-526.
    • (1991) Journal of Colloid Interface Science , vol.143 , pp. 513-526
    • Stenberg, E.1    Persson, B.2    Roos, H.3    Urbaniczky, C.4
  • 42
    • 0027202093 scopus 로고
    • Human immunodeficiency virus reverse transcriptase: Expression in Escherichia coli, purification, and characterization of a functionally and structurally asymmetric dimeric polymerase
    • Thimmig, R. L. & McHenry, C. S. (1993). Human immunodeficiency virus reverse transcriptase: expression in Escherichia coli, purification, and characterization of a functionally and structurally asymmetric dimeric polymerase. Journal of Biological Chemistry 268, 16528-16536.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 16528-16536
    • Thimmig, R.L.1    McHenry, C.S.2
  • 43
    • 0023788116 scopus 로고
    • Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: Role of the C terminus in antibody reactivity and enzyme function
    • Tisdale, M., Ertl, P., Larder, B. A., Purifoy, D. J. M., Darby, G. & Powell, K. L. (1988). Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: role of the C terminus in antibody reactivity and enzyme function. Journal of Virology 62, 3662-3667.
    • (1988) Journal of Virology , vol.62 , pp. 3662-3667
    • Tisdale, M.1    Ertl, P.2    Larder, B.A.3    Purifoy, D.J.M.4    Darby, G.5    Powell, K.L.6
  • 44
    • 0027280807 scopus 로고
    • Monoclonal antibody-mediated inhibition of HIV-1 reverse transcriptase polymerase activity
    • Wu, J., Amandoron, E., Li, X., Wainberg, M. A. & Parniak, M. A. (1993). Monoclonal antibody-mediated inhibition of HIV-1 reverse transcriptase polymerase activity. Journal of Biological Chemistry 268, 9980-9985.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 9980-9985
    • Wu, J.1    Amandoron, E.2    Li, X.3    Wainberg, M.A.4    Parniak, M.A.5
  • 45
    • 0023844681 scopus 로고
    • High performance liquid chromatography of mouse monoclonal antibodies on spherical hydroxyapatite beads
    • Yamakawa, Y. & Chiba, J. (1988). High performance liquid chromatography of mouse monoclonal antibodies on spherical hydroxyapatite beads. Journal of Liquid Chromatography 11, 665-681.
    • (1988) Journal of Liquid Chromatography , vol.11 , pp. 665-681
    • Yamakawa, Y.1    Chiba, J.2


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