Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells

Cell Biology International

Volumn 34, Issue 8, 2010, Pages 815-826

  Virtanen, Sanna S ^a   Sandholm, Jouko ^a   Yegutkin, Gennady ^c   Väänänen, H Kalervo ^a   Härkönen, Pirkko L ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Actin cytoskeleton; Cofilin; Invasion; Mevalonate pathway; Prenyltransferase inhibitor; Prostate cancer

Indexed keywords

ALENDRONIC ACID; COFILIN; F ACTIN; FOCAL ADHESION KINASE; GELATINASE B; GERANYLGERANYLTRANSFERASE I; GERANYLGERANYLTRANSFERASE II; GERANYLTRANSFERASE; GGTI 298; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; NE 10790; P21 ACTIVATED KINASE 2; PAXILLIN; PROTEIN FARNESYLTRANSFERASE; SMALL INTERFERING RNA; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CYTOSKELETON; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; GENE DISRUPTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INHIBITION KINETICS; MALE; METASTASIS INHIBITION; PRENYLATION; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; ALKYL AND ARYL TRANSFERASES; BENZAMIDES; DIPHOSPHONATES; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; MALE; METHIONINE; MICROFILAMENTS; P21-ACTIVATED KINASES; PAXILLIN; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN PRENYLATION; PYRIDINES; RNA INTERFERENCE; TUMOR CELLS, CULTURED;

EID: 77956108573     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20090288     Document Type: Article

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