Basics on mycotherapy: Preliminary concepts on the medicinal use of mycelia;Introduction à la mycothérapie: géné ralités sur l'intérêt des principaux mycelia

Phytotherapie

Volumn 8, Issue 3, 2010, Pages 191-197

  Donatini, B ^a  

^a Médecine Information Éducation ^*  (France)

Author keywords

Auto immunity; Cancer; Immunity; Mushroom; Virus

Indexed keywords

FUNGAL EXTRACT;

AGARICUS BLAZEI; ALLOPATHY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARMILLARIA MELLEA; AUTOIMMUNITY; CORIOLUS VERSICOLOR; FUNGUS; GANODERMA LUCIDUM; GRIFOLA FRONDOSA; HERICIUM ERINACEUS; IMMUNOSTIMULATION; LENTINULA EDODES; MYCELIUM; NONHUMAN; PHELLINUS INTEUS; PLEUROTUS OSTREATUS; POLYPORUS UMBELLATUS; REVIEW;

EID: 77956063133     PISSN: 16248597     EISSN: 17652847     Source Type: Journal    
DOI: 10.1007/s10298-010-0549-6     Document Type: Review

References (124)

1. W.S. Ahn D.J. Kim G.T. Chae 2004 Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy Int J Gynecol Cancer 14 589 94 15304151 10.1111/j.1048-891X.2004.14403.x
2. S. Arinaga N. Karimine K. Takamuku 1992 Enhanced production of interleuk in 1 and tumor necrosis factor by peripheral monocytes after lentinan administration in patients with gastric carcinoma Int J Immunopharmacol 14 1 43 7 1582733 10.1016/0192-0561(92)90103-R 1:CAS:528:DyaK38XhsVenur4%3D
3. J.R. Baker J.S. Kim S.Y. Park 2008 Composition and proposed structure of a water-soluble glycan from the Keumsa Sangwhang Mushroom (Phellinus linteus) Fitoterapia 79 5 345 50 18538951 10.1016/j.fitote.2008.03.002 1:CAS:528:DC%2BD1cXosVOnsbk%3D
4. X.F. Bao Y. Zhen L. Ruan 2002 Purification, characterization, and modification of T lymphocyte-stimulating polysaccharide from spores of Ganoderma lucidum Chem Pharm Bull (Tokyo) 50 5 623 9 10.1248/cpb.50.623 1:CAS:528:DC%2BD38Xks12lu74%3D
5. P. Bobek S. Galbavy L. Ozdin 1998 Effect of oyster mushroom (Pleurotus ostreatus) on pathological changes in dimethylhydrazine-induced rat colon cancer Oncol Rep 5 3 727 30 9538185 1:STN:280:DyaK1c3gslWmsQ%3D%3D
6. P. Bobek L. Ozdín S. Galbavý 1998 Dose- and time-dependent hypocholesterole em mic effect of oyster mushroom (Pleurotus ostreatus) in rats Nutrition 14 3 282 6 9583372 10.1016/S0899-9007(97)00471-1 1:STN:280: DyaK1c3kt1Kktg%3D%3D
7. P. Bobek V. Nosálová S. Cerná 2001 Effect of pleuran (beta-glucan from Pleurotus ostreatus) in diet or drinking fluid on colitis in rats Nahrung 45 5 360 3 11715351 10.1002/1521-3803(20011001)45:5<360::AID- FOOD360>3.0.CO;2-C 1:CAS:528:DC%2BD3MXotlGjsrs%3D
8. I.A. Butovich V.D. Semichaevskǐ 1986 Catalytic properties of extracellular phenol oxidases from the higher basidiomycete Pleurotus ostreatus (Fr.) Kumm (Article in Russian) Ukr Biokhim Zh 58 4 18 26 3090755 1:CAS:528:DyaL28Xlt12rtbs%3D
9. Y. Cheng R. Chaturvedi M. Asim 2005 Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc J Biol Chem 280 23 22492 6 15843384 10.1074/jbc.C500122200 1:CAS:528: DC%2BD2MXksl2htbw%3D
10. Y.H. Choi G.H. Yan O.H. Chai 2006 Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus Biol Pharm Bull 29 7 1360 5 16819169 10.1248/bpb.29.1360 1:CAS:528:DC%2BD28XovFKqsb0%3D
11. V. Chorváthová P. Bobek E. Ginter 1993 Effect of the oyster fungus on glycaemia and cholesterolaemia in rats with insulin-dependent diabetes Physiol Res 42 3 175 9
12. F. Di Mario P. Rapanà U. Tomati 2008 Chitin and chitosan from Basidiomycetes Int J Biol Macromol 43 1 8 12 18023863 10.1016/j.ijbiomac.2007. 10.005 1:CAS:528:DC%2BD1cXmvFSms7c%3D
13. Donatini B, Le Blaye I (2002) Mushrooms and weight loss: a randomized double blind study. IMC7 Oslo, p. 97 (conference 306)
14. T. Ebina Y. Fujimiya T. Yamaguchi 1998 The use of BRM-activated killer cells in adoptive immunotherapy: a pilot study with nine advanced cancer patients Biotherapy 11 4 241 53 9950100 10.1023/A:1008047628284 1:CAS:528:DyaK1MXhtFynsLg%3D
15. L.K. Ellertsen G. Hetland 2009 An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy Clin Mol Allergy 7 6 19416507 10.1186/1476-7961-7-6 1:CAS:528:DC%2BD1MXmt1ertrk%3D
16. S.K. Eo Y.S. Kim C.K. Lee 2000 Possible mode of antiviral activity of acidic protein bound polysaccharide isolated from Ganoderma lucidum on herpes simplex viruses J Ethnopharmacol 72 475 81 10996289 10.1016/S0378-8741(00)00266- X 1:CAS:528:DC%2BD3cXms1Sqtr8%3D
17. Y. Fujimiya Y. Suzuki R. Katakura 1999 Tumor-specific cytocidal and immunopotentiating effects of relatively low molecular weight products derived from the basidiomycete, Agaricus blazei Murill Anticancer Res 19 1A 113 8 10226531 1:STN:280:DyaK1M3ktlWiug%3D%3D
18. M. Fukuzawa R. Yamaguchi I. Hide 2008 Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its antitumor activity Biol Pharm Bull 31 10 1933 7 18827358 10.1248/bpb.31.1933 1:CAS:528:DC%2BD1cXhsVOjtbbL
19. Y. Gao S. Zhou W. Jiang 2003 Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients Immunol Invest 32 201 15 12916709 10.1081/IMM-120022979
20. B. Grinde G. Hetland E. Johnson 2006 Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection Int Immunopharmacol 6 8 1311 4 16782544 10.1016/j.intimp.2006.04.005 1:CAS:528:DC%2BD28XlvF2ktr4%3D
21. Y.H. Gu G. Sivam 2006 Cytotoxic effect of oyster mushroom Pleurotus ostreatus on human androgen-independent prostate cancer PC-3 cells J Med Food 9 2 196 204 16822205 10.1089/jmf.2006.9.196 1:CAS:528:DC%2BD28XmsFWmtrs%3D
22. N. Gunde-Cimerman A. Cimerman 1995 Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin Exp Mycol 19 1 1 6 7614366 10.1006/emyc.1995.1001 1:CAS:528:DyaK2MXlt1aqu7o%3D
23. A. Gutiérrez A. Prieto A.T. Martínez 1996 Structural characterization of extracellular polysaccharides produced by fungi from the genus Pleurotus Carbohydr Res 281 1 143 54 8839181 10.1016/0008-6215(95)00342-8
24. M. Haak-Frendscho K. Kino T. Sone 1993 Ling Zhi-8:a novel T cell mitogen induces cytokine production and upregulation of ICAM-1 expression Cell Immunol 150 101 13 8102083 10.1006/cimm.1993.1182
25. S.B. Han C.W. Lee J.S. Kang 2006 Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion Int Immunopharmacol 6 4 697 702 16504934 10.1016/j.intimp.2005.10.003 1:CAS:528:DC%2BD28XhslyrsLk%3D
26. N. Hatvani 2001 Antibacterial effect of the culture fluid of Lentinus edodes mycelium grown in submerged liquid culture Int J Antim microb Agents 17 1 71 4 10.1016/S0924-8579(00)00311-3 1:CAS:528:DC%2BD3MXnslSktg%3D%3D
27. C.L. Hawkins B.E. Brown M.J. Davies 2001 Hypochlorite- and hypobromite-mediated radical formation and its role in cell lysis Arch Biochem Biophys 395 2 137 45 11697850 10.1006/abbi.2001.2581 1:CAS:528: DC%2BD3MXotVynsL8%3D
28. M. Higaki F. Eguchi Y. Watanabe 1997 A stable culturing method and pharmacological effects of the Agaricus blazei Nippon Yakurigaku Zasshi (Japanese) 110 1 98P 103P
29. S.A. Hong K. Kim S.J. Nam 2008 A case-control study on the dietary intake of mushrooms and breast cancer risk among Korean women Int J Cancer 122 919 923 17943725 10.1002/ijc.23134 1:CAS:528:DC%2BD1cXhsFShsLY%3D
30. C.H. Hsu K.C. Hwang Y.H. Chiang P. Chou 2008 The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B J Altern Complement Med 14 3 299 301 18370584 10.1089/acm.2006.6344
31. H. Hu N.S. Ahn X. Yang 2002 Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell Int J Cancer 102 3 250 3 12397644 10.1002/ijc.10707 1:CAS:528:DC%2BD38XotlaitLw%3D
32. T. Ikekawa H. Maruyama T. Miyano 1985 Proflamin, a new antitumor agent: preparation, physicochemical properties and anti-tumor activity Jpn J Cancer Res 76 2 142 8 3920103 1:CAS:528:DyaL2MXhvVans7o%3D
33. Y. Inaoka A. Shakuya H. Fukazawa 1994 Studies on active substances in herbs used for hair treatment. I. Effects of herb extracts on hair growth and isolation of an active substance from Polyporus umbellatus F Chem Pharm Bull (Tokyo) 42 3 530 3 1:CAS:528:DyaK2cXkvFWhurg%3D
34. N. Inagaki T. Shibata T. Itoh 2005 Inhibition of IgE-dependent mouse triphasic cutaneous reaction by a boiling water fraction separated from mycelium of Phellinus linteus Evid Based Complement Alternat Med 2 3 369 74 16136215 10.1093/ecam/neh105
35. A. Inoue N. Kodama H. Nanba 2002 Effect of maitake (Grifola frondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion Biol Pharm Bull 25 4 536 40 11995941 10.1248/bpb.25.536 1:CAS:528:DC%2BD38XkslWrsbw%3D
36. K. Irinoda K.N. Masihi G. Chihara 1992 Stimulation of microbicidal host defence mechanisms against aerosol influenza virus infection by lentinan Int J Immunopharmacol 14 6 971 7 1428370 10.1016/0192-0561(92)90140-G 1:CAS:528:DyaK38Xls1emsLk%3D
37. H. Ishida Y. Inaoka J. Shibatani 1999 Studies of the active substances in herbs used for hair treatment. II. Isolation of hair regrowth substances, acetosyringone and polyporusterone A and B, from Polyporus umbellatus Fries Biol Pharm Bull 22 11 1189 92 10598026 1:CAS:528:DyaK1MXns1Gqsr0%3D
38. H. Itoh H. Ito H. Hibasami 2008 Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells Oncol Rep 20 6 1359 61 19020714 1:CAS:528:DC%2BD1MXjs1Ghsw%3D%3D
39. Y. Kabir M. Yamaguchi S. Kimura 1987 Effect of shiitake (Lentinus edodes)and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats J Nutr Sci Vitaminol (Tokyo) 33 5 341 6 1:CAS:528:DyaL1cXlsVymsA%3D%3D
40. Y. Kariya N. Inoue T. Kihara 1992 Activation of human natural killer cells by the protein-bound polysaccharide PSK independently of interferon and interleukin 2 Immunol Lett 31 241 5 1372283 10.1016/0165-2478(92)90121-4 1:CAS:528:DyaK38XhsVenu74%3D
41. G.Y. Kim S.H. Kim S.Y. Hwang 2003 Oral administration of proteoglycan isolated from Phellinus linteus in the prevention and treatment of collagen-induced arthritis in mice Biol Pharm Bull 26 6 823 31 12808294 10.1248/bpb.26.823
42. H.M. Kim S.B. Han G.T. Oh 1996 Stimulation of humoral andcell mediated immunity by polysaccharide from mushroom Phellinus linteus Int J Immunopharmacol 18 5 295 303 8933208 10.1016/0192-0561(96)00028-8 1:CAS:528:DyaK28XntVOisbc%3D
43. Y. Kimura T. Kido T. Takaku 2004 Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and anti-metastatic actions Cancer Sci 95 9 758 64 15471563 10.1111/j.1349-7006.2004.tb03258.x 1:CAS:528:DC%2BD2cXpvFOgu70%3D
44. E. Kishida C. Kinoshita Y. Sone A. Misaki 1992 Structures and antitumor activities of polysaccharides isolated from mycelium of Volvariella volvacea Biosci Biotechnol Biochem 56 8 1308 9 1368842 10.1271/bbb.56.1308 1:CAS:528:DyaK38Xls1egtLg%3D
45. N. Kochibe K.L. Matta 1989 Purification and properties of an N-acetylglucosamine-specific lectin from Psathyrella velutina mushroom J Biol Chem 264 1 173 7 2909513 1:CAS:528:DyaL1MXltlWrtA%3D%3D
46. E.V. Kolotushkina M.G. Moldavan K.Y. Voronin G.G. Skibo 2003 The influence of Hericium erinaceus extract on myelination process in vitro Fiziol Zh 49 1 38 45 12675022 1:STN:280:DC%2BD3s7lsl2ktQ%3D%3D
47. S. Konno D.G. Tortorelis S.A. Fullerton 2001 A possible hypoglycaemic effect of maitake mushroom on type 2 diabetic patients Diabet Med 18 12 1010 11903406 10.1046/j.1464-5491.2001.00532-5.x 1:STN:280:DC%2BD387mvFKruw%3D%3D
48. H. Kreutzmann T.M. Fliedner H.J. Galla E. Sackmann 1978 Fluorescence-polarization changes in mononuclear blood leucocytes after PHA incubation: differences in cells from patients with and without neoplasia Br J Cancer 37 797 805 656307 1:CAS:528:DyaE1cXlsVClurs%3D
49. K. Kubo H. Nanba 1996 The effect of maitake mushrooms on liver and serum lipids Altern Ther Health Med 2 5 62 6 8795938 1:STN:280:DyaK28zovVGgug%3D%3D
50. S. Kurashige Y. Akuzawa F. Endo 1997 Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine Immunopharmacol Immunotoxicol 19 2 175 83 9130004 10.3109/08923979709007657 1:CAS:528:DyaK2sXjtl2itbc%3D
51. B. Lakshmi T.A. Ajith N. Sheena 2003 Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum occurring in South India Teratog Carcinog Mutagen Suppl 1 85 97 10.1002/tcm.10065 1:CAS:528:DC%2BD3sXitFymurY%3D
52. I. Lavi D. Friesem S. Geresh 2006 An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells Cancer Lett 244 1 61 70 16413114 10.1016/j.canlet.2005.12.007 1:CAS:528:DC%2BD28XhtVGit7fJ
53. E.W. Lee K. Shizuki S. Hosokawa 2000 Two novel diterpenoids, erinacines H and I from the mycelia of Hericium erinaceum Biosci Biotechnol Biochem 64 11 2402 5 11193408 10.1271/bbb.64.2402 1:CAS:528:DC%2BD3cXos1SrtLk%3D
54. S.Y. Lee H.M. Rhee 1990 Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action Chem Pharm Bull (Tokyo) 38 5 1359 64 1:STN:280: DyaK3czmslajuw%3D%3D
55. J.H. Lee S.J. Lee Y.H. Choi 2006 Effects of mycelial culture of Phellinus linteus on ethanol-induced gastric ulcer in rats Phytother Res 20 5 396 402 16619369 10.1002/ptr.1868
56. B.O. Lim T.I. Jeon S.G. Hwang 2005 Phellinus linteus grown on germinated brown rice suppresses IgE production by the modulation of Th1/Th2 balance in murine mesenteric lymph node lymphocytes Biotechnol Lett 27 9 613 7 15977066 10.1007/s10529-005-4474-y 1:CAS:528:DC%2BD2MXlsFaksLo%3D
57. J. Liu H. McIntosh H. Lin 2001 Chinese medicinal herbs for chronic hepatitis B: a systematic review Liver 21 4 280 6 11454192 10.1034/j.1600-0676. 2001.021004280.x 1:STN:280:DC%2BD3MvltVOrsg%3D%3D
58. Q.L. Liu S. Sato T. Kishikawa 2001 Effectiveness of a traditional Chinese medicine, Wulingsan, in suppressing the development of nephrocalc cinosis induced by a high phosphorus diet in young rats Med Electron Microsc 34 2 103 14 11685659 10.1007/s007950170004 1:CAS:528:DC%2BD38XitFCltQ%3D%3D
59. W.K. Liu T.B. Ng S.F. Sze K.W. Tsui 1993 Activation of peritoneal macrophages by polysaccharopeptide from the mushroom, Coriolus versicolor Immunopharmacology 26 2 139 46 8282538 10.1016/0162-3109(93)90006-C 1:CAS:528:DyaK2cXhsFeju7c%3D
60. H. Lu E. Kyo T. Uesaka 2002 Prevention of development of N,N'-dimethylhydrazine-induced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia in male ICR mice Int J Mol Med 9 113 7 11786919
61. H. Matsuoka Y. Seo H. Wakasugi 1997 Lentinan potentiates immunity and prolongs the survival time of some patients Anti-cancer Res 17 4A 2751 5 1:CAS:528:DyaK2sXlsFajsb0%3D
62. C.G. Mendoza J.A. Leal M. Novaes-Ledieu 1979 Studies of the spore walls of Agaricus bisporus and Agaricus campestris Can J Microbiol 25 1 32 9 570877 10.1139/m79-005 1:STN:280:DyaE1M7ks1KitA%3D%3D
63. B.S. Min B.S. Yun H.K. Lee 2006 Two novel furan derivatives from Phellinus linteus with anti-complement activity Bioorg Med Chem Lett 16 12 3255 7 16581246 10.1016/j.bmcl.2006.03.027 1:CAS:528:DC%2BD28XksFeqs78%3D
64. M. Mizuno 2000 Antitumor polysaccharides from mushrooms during storage Biofactors 12 1-4 275 81 11216496 10.1002/biof.5520120141 1:CAS:528: DC%2BD3MXhsFensrs%3D
65. Y. Mizutani O. Yoshida 1991 Activation by the protein-bound polysaccharide PSK (krestin) of cytotoxic lymphocytes that act on fresh autologous tumor cells and T24 human urinary bladder transitional carcinoma cell line in patients with urinary bladder cancer J Urol 145 5 1082 7 2016797 1:STN:280:DyaK3M3gt1KmtQ%3D%3D
66. C. Moinard L. Cynober J.P. de Bandt 2005 Polyamines: metabolism and implications in human diseases Clin Nutr 24 2 184 97 15784477 10.1016/j.clnu.2004.11.001 1:CAS:528:DC%2BD2MXisVCmtr0%3D
67. Y. Monma T. Kawana F. Shimizu 1997 In vitro inactivation of herpes simplex virus by a biological response modifier, PSK Antiviral Res 35 3 131 8 9298752 10.1016/S0166-3542(97)00021-1 1:CAS:528:DyaK2sXltl2nt74%3D
68. K. Mori S. Inatomi K. Ouchi 2009 Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial Phytother Res 23 3 367 72 18844328 10.1002/ptr.2634 1:CAS:528:DC%2BD1MXkt1egt74%3D
69. A. Morigiwa K. Kitabatake Y. Fujimoto N. Ikekawa 1986 Angiotensin converting enzyme-inhibiting triterpenes from Ganoderma lucidum Chem Phar Bull 34 3025 3028 1:CAS:528:DyaL28Xls1yqsrg%3D
70. M. Mukai A. Kasai N. Hiramatsu 2008 Blockade of the aryl hydrocarbon receptor pathway triggered by dioxin, polycyclic aromatic hydrocarbons and cigarette smoke by Phellinus linteus Biol Pharm Bull 31 10 1888 93 18827349 10.1248/bpb.31.1888 1:CAS:528:DC%2BD1cXhsVOjtbnE
71. M. Nagao T. Sato N. Akimoto 2009 Augmentation of sebaceous lipogenesis by an ethanol extract of Grifola frondosa (Maitake mushroom) in hamsters in vivo and in vitro Exp Dermatol 18 8 730 3 19228191 10.1111/j.1600-0625.2008.00831.x
72. R. Nakai H. Masui H. Horio M. Ohtsuru 1999 Effect of maitake (Grifola frondosa) water extract on inhibition of adipocyte conversion of C3H10T1/2B2C1 cells J Nutr Sci Vitaminol (Tokyo) 45 3 385 9 1:CAS:528:DyaK1MXksVOrtrs%3D
73. H. Nakazato A. Koike S. Saji 1994 Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study group of immunochemotherapy with PSK for gastric cancer Lancet 343 1122 6 7910230 10.1016/S0140-6736(94)90233-X 1:STN:280:DyaK2c3jvFShtQ%3D%3D
74. K.S. Nam M.K. Kim Y.H. Shon 2007 Chemopreventive effect of chitosan oligosaccharide against colon carcinogenesis J Microbiol Biotechnol 17 9 1546 9 18062235 1:CAS:528:DC%2BD2sXht1GksL7J
75. H. Nanba 1995 Activity of maitake D-fraction to inhibit carcinogenesis and metastasis Ann N Y Acad Sci 768 243 5 8526356 10.1111/j.1749-6632.1995. tb12130.x 1:CAS:528:DyaK28XitV2it7s%3D
76. I.J. Nieto Ramírez C. Chegwin Angarita H.J. Osorio Zuloaga 2007 Incorporation of caffeine into the macromicete fungus Pleurotus sajor-caju growing on coffee pulp (Article in Spanish) Rev Iberoam Micol 24 1 72 4 17592899 10.1016/S1130-1406(07)70008-6
77. J. Ning W. Zhang Y. Yi 2003 Synthesis of beta-(1→6)-branched beta-(1→3) glucohexaose and its analogues containing an alpha-(1→3) linked bond with antitumor activity Bioorg Med Chem 11 10 2193 203 12713829 10.1016/S0968-0896(03)00118-4 1:CAS:528:DC%2BD3sXjtFWhs7o%3D
78. Y.C. Niu J.C. Liu X. M. Zhao 2009 Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice Pharmazie 64 7 472 6 19694186 1:CAS:528:DC%2BD1MXhtVCgs7nJ
79. Y.C. Niu J.C. Liu X.M. Zhao X.X. Wu 2009 A low molecular weight polysaccharide isolated from Agaricus blazei suppresses tumor growth and angiogenesis in vivo Oncol Rep 21 1 145 52 19082455 1:STN:280: DC%2BD1M%2Fjt12ktg%3D%3D
80. H.K. No S.P. Meyers 2000 Application of chitosan for treatment of wastewaters Rev Environ Contam Toxicol 163 1 27 10771583 1:CAS:528: DC%2BD3cXitVOhtr4%3D
81. V. Nosál'ová P. Bobek S. Cerná 2001 Effects of pleuran (beta-glucan isolated from Pleurotus ostreatus) on experimental colitis in rats Physiol Res 50 6 575 81 11829318
82. N. Ohno M. Furukawa N.N. Miura 2001 Antitumor beta glucan from the cultured fruit body of Agaricus blazei Biol Pharm Bull 24 7 820 8 11456124 10.1248/bpb.24.820 1:CAS:528:DC%2BD3MXkvVaqsro%3D
83. L.M. Ojemann W.L. Nelson D.S. Shin 2006 Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions Epilepsy Behav 8 2 376 83 16461011 10.1016/j.yebeh.2005.12.009
84. M. Okazaki Y. Adachi N. Ohno T. Yadomae 1995 Structure-activity relationship of (1-3)-beta-D-glucans in the induction of cytokine production from macrophages, in vitro Biol Pharm Bull 18 10 1320 7 8593430 1:CAS:528:DyaK2MXpsFCnsbs%3D
85. K. Oshiman Y. Fujimiya T. Ebina 2002 Orally administered beta-1,6-D-polyglucose extracted from Agaricus blazei results in tumor regression in tumor-bearing mice Planta Med 68 7 610 4 12142994 10.1055/s-2002-32904 1:CAS:528:DC%2BD38XlslKltrk%3D
86. M.M. Padilha A.A. Avila P.J. Sousa 2009 Anti-inflammatory activity of aqueous and alkaline extracts from mushrooms (Agaricus blazei Murill) J Med Food 12 2 359 64 19459738 10.1089/jmf.2008.0177 1:CAS:528:DC%2BD1MXmtlWrs7w%3D
87. G. Palmieri P. Giardina L. Marzullo 1993 Stability and activity of a phenol oxidase from the ligninolytic fungus Pleurotus ostreatus Appl Microbiol Biotechnol 39 4-5 632 6 7763931 10.1007/BF00205066 1:CAS:528:DyaK3sXmsVCju7s%3D
88. A. Pusztai S.W. Ewen G. Grant 1993 Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins Br J Nutr 70 1 313 21 8399111 10.1079/BJN19930124 1:CAS:528:DyaK3sXmtVantLg%3D
89. U. Rau A. Kuenz V. Wray 2009 Production and structural analysis of the polysaccharide secreted by Trametes (Coriolus) versicolor ATCC 200801 Appl Microbiol Biotechnol 81 5 827 37 18800181 10.1007/s00253-008-1700-2 1:CAS:528:DC%2BD1cXhsFart7%2FO
90. T.L. Rizner M. Zakelj-Mavric 2000 Characterization of fungal 17-beta-hydroxysteroid dehydrogenases Comp Biochem Physiol B Biochem Mol Biol 127 1 53 63 11126752 10.1016/S0305-0491(00)00234-0 1:STN:280: DC%2BD3M3ls1CitA%3D%3D
91. T. Saito F. Aoki H. Hirai 1998 Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ramosum J Antibiot (Tokyo) 51 11 983 90 1:CAS:528:DyaK1cXnslyku7k%3D
92. H. Sakagami T. Aoki A. Simpson S. Tanuma 1991 Induction of immunopotentiation activity by a protein-bound polysaccharide, PSK (review) Anticancer Res 11 2 993 9 2064356 1:CAS:528:DyaK3MXlsV2mu7Y%3D
93. N. Shouji K. Takada K. Fukushima M. Hirasawa 2000 Anticaries effect of a component from shiitake (an edible mushroom) Caries Res 34 1 94 8 10601791 10.1159/000016559 1:STN:280:DC%2BD3c%2FmvFaluw%3D%3D
94. D. Sliva C. Labarrere V. Slivova 2002 Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells Biochem Biophys Res Commun 298 603 12 12408995 10.1016/S0006-291X(02)02496-8 1:CAS:528: DC%2BD38XotFSns7Y%3D
95. K. Sorimachi Y. Ikehara G. Maezato 2001 Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by western equine encephalitis (WEE) virus on VERO cells in vitro Biosci Biotechnol Biochem 65 7 1645 7 11515550 10.1271/bbb.65.1645 1:STN:280:DC%2BD3MvntFSjsA%3D%3D
96. M. Stadler A. Mayer H. Anke O. Sterner 1994 Fatty acids and other compounds with nematicidal activity from cultures of Basidiomycetes Planta Med 60 2 128 32 8202563 10.1055/s-2006-959433 1:CAS:528:DyaK2cXkt1KgsLc%3D
97. C.H. Su C.S. Sun S.W. Juan 1997 Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes Biomaterials 18 17 1169 74 9259514 10.1016/S0142-9612(97)00048-3 1:CAS:528:DyaK2sXkvVCnsLw%3D
98. K. Sugiyama A. Yamakawa 1996 Dietary eritaden nine-induced alteration of molecular species composition of phospholipids in rats Lipids 31 4 399 404 8743052 10.1007/BF02522926 1:CAS:528:DyaK28XisFSiurc%3D
99. C.M. Sun Q.D. Li S.Q. Wang 1992 Clinical study of rapid bladder filling agent Zhongguo Zhong Xi Yi Jie He Za Zhi 12 9 533 4 1298469
100. I. Suzuki K. Hashimoto S. Oikawa 1989 Antitumor and immunomodulating activities of a beta-glucan obtained from liquid-cultured Grifola frondosa Chem Pharm Bull (Tokyo) 37 2 410 3 1:CAS:528:DyaL1MXhvVGnurs%3D
101. T. Takaku Y. Kimura H. Okuda 2001 Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action J Nutr 131 5 1409 13 11340091 1:CAS:528:DC%2BD3MXjs1agsbc%3D
102. M. Torisu Y. Hayashi T. Ishimitsu 1990 Significant prolongation of disease-free period gained by oral polysaccharide K (PPSK) administration after curative surgical operation of colorectal cancer Cancer Immunol Immunother 31 5 261 8 2198088 10.1007/BF01740932 1:STN:280:DyaK3czivFKisw%3D%3D
103. S. Tsujitani Y. Kakeji H. Orita 1992 Postoperative adjuvant immunochemotherapy and infiltration of dendritic cells for patients with advanced gastric cancer Anticancer Res 12 3 645 8 1622120 1:STN:280: DyaK38zitFKmuw%3D%3D
104. C. Wang S. Guo X. Chen 1996 Contents of armillarin and melleolid at different stages of development of Armillaria mellea (Vahl ex Fr.) Quel Zhongguo Zhong Yao Za Zhi 21 5 274 6 9388931 1:CAS:528:DyaK28XmslWnurc%3D
105. 2, and HOCl Arch Biochem Biophys 304 1 189 96 8391779 10.1006/abbi.1993.1338 1:STN:280:DyaK3szht1SjsA%3D%3D
106. Y. Wang S.Y. Mo S.J. Wang 2005 A unique highly oxygenated pyrano [4,3-c] [2] benzopyran-1,6-dione derivative with antioxidant and cytotoxic activities from the fungus Phellinus igniarius Org Lett 7 9 1675 8 15844878 10.1021/ol0475764 1:CAS:528:DC%2BD2MXivVertbc%3D
107. S.P. Wasser 2002 Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides Appl Microbiol Biotechnol 60 3 258 74 12436306 10.1007/s00253-002-1076-7 1:CAS:528:DC%2BD38XoslOrtrk%3D
108. N. Watanabe T. Obuchi M. Tamai 1990 A novel N6-substituted adenosine isolated from mi huan jun (Armillaria mellea)as a cerebral-protecting compound Planta Med 56 1 48 52 2356243 10.1055/s-2006-960882 1:CAS:528:DyaK3cXksFagsbk%3D
109. S.J. Won M.T. Lin W.L. Wu 1992 Ganoderma tsugae mycelium enhances splenic natural killer cell activity and serum interferon production in mice. Proflamin, a new antitumor agent: preparation, physicochemical propertie es and antitumor activity Jpn J Pharmacol 59 2 171 6 1279250 10.1254/jjp.59.171 1:CAS:528:DyaK38XltV2ktbc%3D
110. S.J. Wu J.Y. Tsai M.N. Lai L.T. Ng 2007 Armillariella mellea shows anti-inflammatory activity by inhibiting the expression of NO, iNOS, COX-2 and cytokines in THP-1 cells Am J Chin Med 35 3 507 16 17597509 10.1142/ S0192415X07005028 1:CAS:528:DC%2BD2sXmslCntr4%3D
111. L.L. Xiong 1993 Therapeutic effect of combined therapy of Salvia miltiorrhizae and Polyporus umbellatus polysaccharide in the treatment of chronic hepatitis B Zhongguo Zhong Xi Yi Jie He Za Zhi 13 9 533 5 8111209 1:STN:280:DyaK2c7lsVCktg%3D%3D
112. C.P. Xu W.W. Liu F.X. Liu 1985 A double-blind study of effectiveness of Hericium erinaceus pers therapy on chronic atrophic gastritis. A preliminary report Chin Med J (Engl) 98 6 455 6 1:STN:280:DyaL28%2FivFGhtA%3D%3D
113. S.Y. Xue X.R. Xu 1991 Effect of yunfujing on the vestibular system Acta Otolaryngol Suppl 481 626 8 1927487 10.3109/00016489109131488 1:STN:280:DyaK38%2FisFWhsw%3D%3D
114. D. Yang S. Li H. Wang 1999 Prevention of postoperative recurrence of bladder cancer: a clinical study Zhonghua Wai Ke Za Zhi 37 8 464 5 11829890 1:STN:280:DC%2BD387gtVSqsQ%3D%3D
115. D. Yuan J. Mori K.I. Komatsu 2004 An anti-aldosteronic diuretic component (drain dampness) in Polyporus sclerotium Biol Pharm Bull 27 867 70 15187435 10.1248/bpb.27.867 1:CAS:528:DC%2BD2cXltFKqtL8%3D
116. F. Yang Y. Ke S. Kuo 2000 Effect of fatty acids on the mycelial growth and polysaccharide formation by Ganoderma lucidum in shake flask cultures Enzyme Microb Technol 27 3-5 295 301 10899556 10.1016/S0141-0229(00)00213-1 1:CAS:528:DC%2BD3cXkslSjt7s%3D
117. J.S. Yang Y.L. Su Y.L. Wang 1989 Isolation and structures of two new sesquiterpenoid aromatic esters: armillarigin and armillarikin1 Planta Med 55 5 479 81 17262464 10.1055/s-2006-962070 1:CAS:528:DyaK3cXpsFGiuw%3D%3D
118. Y. Yaoita K. Danbara M. Kikuchi 2005 Two new aromatic compounds from Hericium erinaceum (Bull: Fr.) PERS (1) Chem Pharm Bull (Tokyo) 53 9 1202 3 10.1248/cpb.53.1202 1:CAS:528:DC%2BD2MXhtFWju77L
119. Yap AT, Ng ML (2002) Lentinan as a possible "oral vaccine" against tumor development. IMC7 Oslo, p. 54 (cconference 168)
120. T. Yokoe Y. Iino H. Takei 1997 HLA antigen as predictive index for the outcome of breast cancer patients with adjuvant immunochemotherapy with PSK Anticancer Res 17 4A 2815 8 9252721 1:CAS:528:DyaK2sXlsFajtr0%3D
121. G.L. Zhang Y.H. Wang W. Ni 2002 Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice World J Gastroenterol 8 728 33 12174387 1:CAS:528:DC%2BD38XntFeqt7k%3D
122. H. Zhang T. Morisaki H. Matsunaga 2000 Protein-bound polysaccharide PSK inhibits tumor invasiveness by down-regulation of TGF-bb and MMPs Clin Exp Metastasis 18 343 52 11448066 1:CAS:528:DC%2BD3MXlsVOrt7w%3D
123. H.N. Zhang J.H. He L. Yuan 2003 In vitro and in vivo protective effect of Ganoderma lucidum polysaccharid des on alloxan-induced pancreatic islets damage Life Sci 73 2307 19 12941433 10.1016/S0024-3205(03)00594-0 1:CAS:528: DC%2BD3sXms12hsL8%3D
124. M. Zhang J. Huang X. Xie C.D. Holman 2009 Dietary intake of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women Int J Cancer 124 1404 8 19048616 10.1002/ijc.24047 1:CAS:528:DC%2BD1MXisFGgs7c%3D