Two novel furan derivatives from Phellinus linteus with anti-complement activity

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 12, 2006, Pages 3255-3257

  Min, Byung Sun ^a   Yun, Bong Sik ^b   Lee, Hyeong Kyu ^b   Jung, Hee Jin ^c   Jung, Hyun Ah ^c   Choi, Jae Sue ^c  

^a Catholic University of Daegu   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Pukyong National University   (South Korea)

Author keywords

Anti complement activity; Furan derivatives; Phellinus linteus; Structural determination

Indexed keywords

ERYTHROCYTE ANTIBODY; FURAN DERIVATIVE; PHELLINUSFURAN A; PHELLINUSFURAN B; UNCLASSIFIED DRUG;

ARTICLE; COMPLEMENT INHIBITION; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; FRUIT; HEMOLYSIS; HUMAN; IC 50; MEDICINAL PLANT; PHELLINUS LINTEUS; SPECTROSCOPY; STEREOISOMERISM;

BASIDIOMYCOTA; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM PROTEINS; FURANS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE;

INONOTUS LINTEUS;

EID: 33646167629     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.027     Document Type: Article

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14. Anti-complement activity was determined by modified method of Mayer. For the classical pathway assay, a diluted solution of normal human serum (80 μL) collected from a healthy volunteer (Man) was mixed with gelatin veronal buffer (80 μL) with or without sample. Each sample was dissolved in DMSO and used as a negative control. The mixture was pre-incubated at 37 °C for 30 min, and sensitized erythrocytes (sheep red blood cells, 40 μL) were added. After incubation under the same conditions, the mixture was centrifuged (4 °C, 1500 rpm) and the optical density of the supernatant (100 μL) was measured at 405 nm. Rosmarinic acid was employed as positive controls.