Engineering allosteric regulation into the hinge region of a circularly permuted TEM-1 -lactamase

Protein Engineering, Design and Selection

Volumn 23, Issue 9, 2010, Pages 699-709

  Mathieu, Valéry ^a   Fastrez, Jacques ^a   Soumillion, Patrice ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

allosteric regulation; hinge region; metallic ions; permuted TEM 1 lactamase; phage display

Indexed keywords

ACTIVE SITE; ALLOSTERIC REGULATION; ALLOSTERIC SITE; BINDING AFFINITIES; BIOCHEMICAL PATHWAY; CONFORMATIONAL CHANGE; DIRECTED EVOLUTION; ENZYMATIC ACTIVITIES; LACTAMASES; METAL ION BINDING; METALLIC IONS; MONOMERIC ENZYMES; PHAGE-DISPLAY; RATIONAL DESIGN; REGULATORY SUBUNITS; TEM; TWO DOMAINS;

BINDING ENERGY; BIOCHEMISTRY; ENZYMES; LAWS AND LEGISLATION; LIGANDS; METAL IONS; ZINC;

BINDING SITES;

BETA LACTAMASE TEM 1; COPPER; HISTIDINE; METAL ION; NICKEL; ZINC ION;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HINGE REGION; PRIORITY JOURNAL;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BETA-LACTAMASES; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; KINETICS; METALS, HEAVY; MODELS, MOLECULAR; MUTATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY;

EID: 77956035832     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq041     Document Type: Article

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