Perspectives emerging from neuroscience on how people become addicted and what to do about it

Journal of Social Work Practice in the Addictions

Volumn 10, Issue 3, 2010, Pages 229-256

  Littrell, Jill ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Genetics of addiction; Incentive salience; Kindling; N acetylcysteine; Neuroscience of addiction; Self regulation

Indexed keywords

EID: 77955995467     PISSN: 1533256X     EISSN: 15332578     Source Type: Journal    
DOI: 10.1080/1533256X.2010.498741     Document Type: Article

References (154)

1. Aarts, H., & Dijksterhuis, A. (2000). Habits as knowledge structures: Automaticity in goal directed behavior. Journal of Personality and Social Psychology, 78, 53-63.
2. Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J.D., Hovarth, T. L. (2006). Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. Journal of Clinical Investigation, 116, 3229-3239.
3. Adler, C. M., Elman, I., Weisenfeld, N., Kestler, L., Pickar, D., & Breier, A. (2000). Effect of acute metabolic stress on striatal dopamine release in healthy volunteers. Neuropsychopharmacology, 22, 545-550.
4. Aguilar de Arcos, F., Verdejo-Garcia, A., Peralta-Ramirez, M. I., Sanchez-Barrera, M., & Perez-García, M. (2005). Experience of emotions in substance abusers exposed to images containing neutral, positive, and negative affective stimuli. Drug and Alcohol Dependence, 78, 159-167.
5. Ahern, G. L., Sollers, J. J., Lane, R. D., Labiner, D. M., Herring, A. M., Weinand, W.E., Thayer, J. F. (2001). Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test. Epilepsia, 42, 912-921.
6. Allen, M. T., Matthews, K. A., & Kenyon, K. L. (2000). The relationships of resting baroreflex sensitivity, heart rate variability and measures of impulse control in children and adolescents. International Journal of Psychophysiology, 37, 185-194.
7. Baldo, B. A., & Kelley, A. E. (2007). Discrete neurochemical coding of distinguishable motivational processes: Insights from nucleus accumbens control of feeding. Psychopharmacology, 191, 439-459.
8. Bargh, J. A., & Chartrand, T. L. (1999). The unbearable automaticity of being. American Psychologist, 54, 462-479.
9. Bargh, J. A., Gollwitzer, P. M., Lee-Chai, A., Barndollar, K., & Trotschel, R. (2001). The automated will: Nonconscious activation and pursuit of behavioral goals. Journal of Personality and Social Psychology, 81, 1014-1027.
10. Baumeister, R. F., Bratslavsky, E., Muraven, M., & Tice, D. M. (1998). Ego depletion: Is the active self a limited resource? Journal of Personality and Social Psychology, 74, 1252-1265.
11. Baumeister, R. F., Gailliot, M., DeWall, C. N., & Oaten M. (2006). Self-regulation and personality: How interventions increase regulatory success, and how depletion moderates the effects of traits on behavior. Journal of Personality, 74, 1773-1801.
12. Baumeister, R. F., Vohs, K. D., & Tice, D. M. (2007). The strength of the self-control. Current Directions in Psychological Science, 16, 351-355.
13. Bechara, A. (2001). Neurobiology of decision making: Risk and reward. Seminars in Clinical Neuropsychiatry, 6, 205-216.
14. Bechara, A. (2003). Risky business: Emotion, decision making and addiction. Journal of Gambling Studies, 19, 23-51.
15. Bechara, A. (2005). Decision making, impulse control, and loss of willpower to resist drugs: A neurocognitive perspective. Nature Neuroscience, 8, 1458-1463.
16. Bechara, A., Noel, X., & Crone, E. A. (2006). Loss of willpower: Abnormal neural mechanisms of impulse control and decision making in addiction. In R.W. Wiers & W. Stacy (Eds.), andbook of implicit cognition and addictions (pp. 215-232). Thousand Oaks, CA: Sage.
17. Belin, D., & Everitt, B. J. (2008). Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron, 57, 432-441.
18. Belin, D., Mar, A., Dalley, J. W., Robbins, T. W., & Everitt, B. J. (2008). High impulsivity predicts the switch to compulsive cocaine-taking. Science, 320, 1352-1354.
19. Berridge, K. C. (2003). Pleasures of the brain. Brain and Cognition, 52, 106-128.
20. Berridge, K. C. (2007a). Brain reward systems for food incentives and hedonics in normal appetite and eating disorders. In T. C. Kirkam & S. J. Cooper (Eds.), Progress in brain research: Appetite and body weight (pp. 191-216). New York: Academic.
21. Berridge, K. C. (2007b). The debate over dopamine's role in reward: The case for incentive salience. Psychopharmacology, 191, 391-431.
22. Berridge, K. C., & Kringelbach, M. L. (2008). Affective neuroscience of pleasure: Reward in humans and animals. Psychopharmacology, 199, 457-480.
23. Berridge K. C., & Robinson, T. E. (1998). What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience. Brain Research Review, 28, 309-369.
24. Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009). Dissecting components of reward: "Liking," "wanting," and learning. Current Opinion in Pharmacology, 9, 65-73.
25. Beveridge, T. J. R., Gill, K. E., Hanlon, C. A., & Porrino, L. J. (2008). Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys. Philosophical Transactions of the Royal Society B, 363, 3257-3266.
26. Bizot, J.-C., Le Bihan, C., Puech, A. J., Hamon, M., & Thiébot, M.-H. (1999). Serotonin and tolerance to delay of reward in rats. Psychopharmacology, 146, 400-412.
27. Boileau, I., Dagher, A., Leyton, M., Gunn, R. N., Baker, G. B., Diksic, M., & Benkelfat, C. (2006). Modeling sensitization to stimulants in humans: an [11C] raclopride/positron emission tomography study in healthy men. Archives of General Psychiatry, 63, 1386-1395.
28. Bostwick, J. M., Hecksel, K. A., Stevens, S. R., Bower, J. H., & Ahlskog, J. E. (2009). Frequency of new-onset pathologic compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson disease. Mayo Clinic Proceedings, 84, 310-316.
29. Brewer, J. A., & Potenza, M.N. (2008). The neurobiology and genetics of impulse control disorders: Relationships to drug addictions. Biochemical Pharmacology, 75, 63-75.
30. Brewer, J. A., Worhunsky, P. D., Carroll, K. M., Rounsaville, B. J., & Potenza, M.N. (2008). Pretreatment brain activation during Stroop task is associated with outcomes in cocaine-dependent patients. Biological Psychiatry, 64, 998-1004.
31. Carroll, K. M., & Onken, L. S. (2005). Behavioral therapies for drug abuse. American Journal of Psychiatry, 162, 1452-1460.
32. Carter, C. S., Grippo, A. J., Pournajafi-Nazarloo, H., Ruscio, M. G., & Porges, S. W. (2008). Oxytocin, vasopressin, and sociality. Progress in Brain Research, 170, 331-336.
33. Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O'Brien, C. P. (1999). Limbic activation during cue-induced cocaine craving. American Journal of Psychiatry, 156, 11-18.
34. Coffey, S. F., Gudleski, G. D., Saladin, M. E., & Brady, K. T. (2003). Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals. Experimental and Clinical Psychopharmacology, 11, 18-25.
35. Colzato, L. S., van den Wildenberg, W. P., & Hommel, B. (2007). Impaired inhibitory control in recreational cocaine users. PLoS ONE, 2(11), e1143. doi:10.1371/journal. Pone.0001143.
36. Cornish, J., & Kalivas, P. (2000). Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. Journal of Neuroscience, 20, 81-85.
37. Crone, E. A., Cutshall, C., Recknor, E., Van den Wildenberg, W. P., & Bechara, A. (2003). Impaired executive function in substance abusers: Evidence from inhibition, set-shifting, and working memory measures. Neuroscience, 663, S8.
38. Cummings, D. E., Naleid, A. M., & Lattemann, D. P. F. (2007). Ghrelin: A link between energy homeostasis and drug abuse? Addiction Biology, 12, 1-5.
39. Dackis, C. A., Kampman, K. M., Lynch, K. G., Pettinati, H. M., & O'Brien, C. P. (2005). A double-blind, placebo-controlled trial of modafinil for cocaine dependence. Neuropsychopharmacology, 30, 205-211.
40. Dackis, C., & O'Brien, C. (2005). Neurobiology of addiction: Treatment and public policy ramifications. Nature Neuroscience, 8, 1431-1436.
41. Dahl, J. P., Kampman, K. M., Oslin, D. W., Weller, A. E., Lohoff, F. W., Ferraro, T. N., Berrettini, W. H. (2005). Association of a polymorphism in the Home1 gene with cocaine dependence in an African American population. Psychiatric Genetics, 15, 277-283.
42. Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004). Prefrontal executive and cognitive function in rodents: Neural and neurochemical substrates. Neuroscience and Biobehavioral Review, 28, 771-784.
43. Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S. J., Theobald, D. E. H., & Laane, K. (2007). Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science, 315, 1267-1270.
44. Desai, P., Roy, A., Brown, S., & Smelson, D. (1997). Impaired color vision in cocaine-withdrawn patients. Archives of General Psychiatry, 54, 696-699.
45. DeWitte, P., Littleton, J., Parot, P., & Koob, G. (2005). Neuroprotective and abstinence-promoting effects of acamprosate. CNS Drugs, 19, 517-537.
46. Di Ciano, P., & Everitt, B. J. (2001). Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine seeking behavior. Neuropsychopharmacology, 25, 341-360.
47. Dood, M. L., Klos, K. J., Bower, J. H., Geda, Y. E., Josephs, K. A., & Ahlskog, J. E. (2005). Pathological gambling caused by drugs used to treat Parkinson disease. Archives of Neurology, 62, 1377-1381.
48. Everitt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W., & Robbins, T.W. (2008). Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philosophical Transactions of the Royal Society B, 363, 3125-3135.
49. Everitt, B. J., & Robbins, T. W. (2005). Neural systems of reinforcement for drug addiction: From actions to habits to compulsion. Nature Neuroscience, 8, 1481-1489.
50. Fabes, R. A., & Eisenberg, N. (1997). Regulatory control and adults' stress-related responses to daily life events. Journal of Personality and Social Psychology, 731, 1107-1117.
51. Faure, A., Reynolds, S. M., Richard, J. M., & Berridge, K. C. (2008). Mesolimbic dopamine in desire and dread: Enabling motivation to be generated by localized glutamate disruptions in nucleus accumbens. Journal of Neuroscience, 28, 7184-7192.
52. Field, M., Mogg, K., & Bradley, B. P. (2006). Attention to drug-related cues in drug abuse and addiction: Component processes. In R.W. Wiers & A. W. Stacy (Eds.), Handbook of implicit cognition and addiction (pp. 151-163). Thousand Oaks, CA: Sage.
53. Fillmore, M. T., Rush, C. R., & Hays, L. (2005). Cocaine improves inhibitory control in a human model of response conflict. Experimental and Clinical Psychopharmacology, 3, 327-335.
54. Fils-Aime, M. L., Eckardt, M. J., George, D. T., Brown, G. L., Mefford, I., & Linnoila, M. (1996). Early onset alcoholics have lower cerebrospinal 5-hydroxyinoleacetic acid levels than late onset alcoholics. Archives of General Psychiatry, 53, 211-216.
55. Fishbein, D. H. (2005). Risky decision making and the anterior cingulate cortex in abstinent drug abusers and nonusers. Cognitive Brain Research, 23, 119-136.
56. Font, L., Mingote, S., Farrar, A. M., Pereira, M., Worden, L., Stopper, C., Salamone, J. D. (2008). Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats. Psychopharmacology, 199, 515-526.
57. Franklin, T. R., Acton, P. D., Maldjian, J. A., Gray, J. D., Croft, J. R., Dackis, C. A., Childress, A. R. (2002). Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. Biological Psychiatry, 51, 134-142.
58. Gailliot, M. T. (2008). Unlocking the energy dynamics of executive functioning: Linking executive functioning to brain glycogen. Perspectives on Psychological Science, 3, 245-263.
59. Gailliot, M. T., Baumeister, R. F., DeWall, C. N., Maner, J. K., Plant, E. A., & Tice, D.M. (2007). Self-control relies on glucose as a limited energy source: Willpower is more than a metaphor. Journal of Personality and Social Psychology, 92, 325-336.
60. Garavan, H., Kaufman, J. N., & Hester, R. (2008). Acute effects of cocaine on the neurobiology of cognitive control. Philosophical Transactions of the Royal Society B, 363, 3267-3276.
61. Garavan, H., Pankiewicz, J., Bloom, A., Cho, J.-K., Sperry, L., & Ross, T. J. (2000). Cue-induced cocaine craving: Neuroanatomical specificity for drug users and drug stimuli. American Journal of Psychiatry 157, 1789-1798.
62. Garavan, H., & Stout, J. C. (2005). Neurocognitive insights into substance abuse. Trends in Cognitive Science, 9, 195-201.
63. Goldstein, R. Z., & Volkow, N. D. (2002). Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry, 159, 1642-1652.
64. Gollwitzer, P. M., Fujita, K., & Oettingen, G. (2004). Planning and the implementation of goals. In R. F. Baumeister & K. D. Vohs (Eds.), Handbook of self-regulation: Research, theory, and applications (pp. 221-228). New York: Guilford.
65. Goodman, A. (2008). Neurobiology of addiction: An integrative review. Biochemical Pharmacology, 75, 266-322.
66. Grant, J. E., Kim, S. W., & Odlaug, B. L. (2007). N-acetyl-cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: A pilot study. Biological Psychiatry, 62, 652-657.
67. Grippo, A. J., Carter, C. S., & Porges, S. W. (2007). Oxytocin affects the heart's response to social isolation. News-Medical.Net. Retrieved May 4, 2009, from http://www.news-medical.net/news/2007/04/30/24353.aspx.
68. Hansen, A. L., Johnsen, B. H., Sollers, J. J., III, Stenvik, K., & Thayer, J. F. (2004). Heart rate variability and its relation to prefrontal cognitive function: The effects of training and detraining. European Journal of Applied Physiology, 93, 263-272.
69. Hansen, A. L., Johnsen, B. H., & Thayer, J. F. (2003). Vagal influence on working memory and sustained attention. International Journal of Psychophysiology, 48, 263-274.
70. Hayano, J., Sakakibara, Y., Yamada, M., Ohte, N., Fujinami, T., Yokoyama, K., Takata, K. (1990). Decreased magnitude of heart rate spectral components in coronary artery disease: Its relation to angiographic severity. Circulation, 81, 1217-1224.
71. Hayano, J., Yasuma, F., Okada, A., Mukai, S., & Fujinami, T. (1996). Respiratory sinus arrhythmia: A phenomenon improving pulmonary gas exchange and circulatory efficiency. Circulation, 94, 842-847.
72. Hester, R., & Garavan, H. (2004). Executive dysfunction in cocaine addiction: Evidence for discordant frontal, cingulated, and cerebral activity. Journal of Neuroscience, 24, 11017-11022.
73. Hyman, S. E. (2005). Addiction: A disease of learning and memory. American Journal of Psychiatry, 162, 1414-1422.
74. Ingjaldsson, J. T., Laberg, J. C., & Thayer, J. F. (2003). Reduced heart rate variability in chronic alcohol abuse: Relationship with negative mood, chronic thought suppression, and compulsive drinking. Biological Psychiatry, 54, 1427-1436.
75. Jentsch, J. D., & Taylor, J. R. (1999). Impulsivity resulting form frontostriatal dysfunction in drug abuse: Implications for the control of behavior by reward-related stimuli. Psychopharmacology, 146, 373-390.
76. Jerlhag, E., Egecioglu, E., Dickson, S. L., Douhan, A., Svensson, L., & Engel, J. A. (2007). Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addiction Biology, 12, 6-16.
77. Kalivas, P. W. (2005). How do we determine which drug-induced neuroplastic changes are important? Nature Neuroscience, 8, 1440-1441.
78. Kalivas, P. W., McFarland, K., Bowers, S., Szumlinski, K., Xi, K.-X., & Baker, D. (2003). Glutamate transmission and addiction to cocaine. Annals of the New York Academy of Sciences, 1003, 169-175.
79. Kalivas, P. W., & Volkow, N. D. (2005). The neural basis of addiction: A pathology of motivation and choice. American Journal of Psychiatry, 162, 1403-1413.
80. Kalivas, P. W., Volkow, N., & Seamans, J. (2005). Unmanageable motivation in addiction: A pathology of prefrontal-accumbens glutamate transmission. Neuron, 45, 647-650.
81. Kelley, A. E. (2004). Memory and addiction: Shared neural circuitry and molecular mechanisms. Neuron, 44, 161-179.
82. Kilts, C. D., Schweitzer, J. B., Quinn, C. K., Gross, R. E., Faber, T. L., Muhammad, F., Drexler, K. P. (2001). Neural activity related to drug craving in cocaine addiction. Archives of General Psychiatry, 58, 334-341.
83. Knackstedt, L. A., & Kalivas, P. W. (2009). Glutamate and reinstatement. Current Opinion in Pharmacology, 9, 59-64.
84. Knoblich, G., Curtis, D., Faustman, W. O., Zarcone, V., Stewart, S., Mefford, I., & King, R. (1992). Increased CSF HVA with craving in long-term abstinent cocaine abusers. Biological Psychiatry, 32, 96-100.
85. Kreek, M. J., Bart, G., Lilly, C., LaForge, K. S., & Nielsen, D. A. (2005). Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacological Review, 57, 1-26.
86. Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience, 8, 1450-1457.
87. LaRowe, S. D., Mardikian, P., Malcolm, R., Myrick, H., Kalivas, P., & McFarland, K. (2006). Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals. American Journal of Addictions, 15, 105-110.
88. LaRowe, S. D., Myrick, H., Hedden, S., Mardikian, P., Saladin, M., McRae, A., Malcolm, R. (2007). Is cocaine desire reduced by N-acetylcysteine? American Journal of Psychiatry, 164, 1115-1117.
89. Lehrer, P., Vaschillo, E., Lu, S. E., Eckberg, D. L., Vaschillo, B., Scardella, A., & Habib, R. (2006). Heart rate variability biofeedback: Effects of age on heart rate variability, baroreflex gain, and asthma. Chest, 129, 278-284.
90. Lehrer, P. M., Vaschillo, E., Vaschillo, B., Lu, S. E., Eckberg, D. L., Edelberg, R., Hamer, R. M. (2003). Heart rate variability biofeedback increases baroreflex gain and peak expiratory flow. Psychosomatic Medicine, 65, 796-805.
91. Lemon, N., & Manahan-Vaughan, D. (2006). Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. Journal of Neuroscience, 26, 7723-7729.
92. Leyton, M. (2007). Conditioned and sensitized responses to stimulant drugs in humans. Progress in Neuropsychopharmacology and Biological Psychiatry, 31, 1601-1613.
93. Littrell, J. (1991a). Understanding and treating alcoholism: Biological, psychological, and social aspects of alcohol consumption and abuse. Hillsdale, NJ: Lawrence Erlbaum.
94. Littrell, J. (1991b). Understanding and treating alcoholism: An empirically based clinician's handbook for the treatment of alcoholism. Hillsdale, NJ: Lawrence.
95. Martijin, C., Tenbult, P., Merckelbach, H., Dreezens, E., & de Vries, N. K. (2002). Getting a grip on ourselves: Challenging expectancies about loss of energy after self-control. Social Cognition, 20, 441-460.
96. McFarland, K., Lapish, C. C., & Kalivas, P. W. (2003). Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. Journal of Neuroscience, 23, 3531-3537.
97. Metcalfe, J., & Mischel, W. (1999). A hot/cool-system analysis of delay of gratification: Dynamics of willpower. Psychological Review, 106, 3-19.
98. Miller, E. K. (2000). The prefrontal cortex and cognitive control. Nature Review Neuroscience, 1, 59-65.
99. Mischel, W., & Ayduk, O. (2004). Willpower in a cognitive-affective processing system. In R. F. Baumeister & K. D. Vohs (Eds.), Handbook of self-regulation: Research, theory, and application (pp. 99-129). New York: Guilford.
100. Montague, P. R., Hyman, S. E., & Cohen, J. D. (2004). Computational roles for dopamine in behavioral control. Nature, 413, 760-767.
101. Moussawi, K., Pacchioni, A., Moran, M., Olive, M. F., Gass, J. T., Lavin, A., & Kalivas, P. W. (2009). N-acetylcysteine reverses cocaine-induced metaplasticity. Nature Neuroscience, 12, 182-189.
102. Muraven, M., & Baumeister, R. F. (2000). Self-regulation and depletion of limited resources: Does self-control resemble a muscle? Psychological Bulletin, 126, 247-259.
103. Muraven, M., & Slessareva, E. (2003). Mechanisms of self-control failure: Motivation and limited resources. Personality and Social Psychology Bulletin, 29, 894-906.
104. Nader, M. A., Czoty, P. W., Gould, R.W., & Riddick, N. V. (2008). Positron emission tomography imaging studies of dopamine receptors in primate models of addiction. Philosophical Transactions of the Royal Society B, 363, 3223-3232.
105. Nader, M. A., Morgan, D., Gage, H. D., Nader, S. H., Calhoun, T. L., Buchheimer, N., Mach, R. H. (2006). PET imaging of dopamine D2 receptors during chronic cocaine self-dministration in monkeys. Nature Neuroscience, 9, 1050-1056.
106. Naqvi, N. H., & Bechara, A. (2009). The hidden island of addiction: The insula. Trends in Neuroscience, 32, 56-76.
107. Nestler, E. J. (2005). Is there a common molecular pathway for addiction? Nature Neuroscience, 8, 1445-1449.
108. Niv, Y., Daw, N. D., Joel, D., & Dayan, P. (2007). Tonic dopamine: Opportunity costs and the control of response vigor. Psychopharmacology, 191, 507-520.
109. Nocjar, C., & Panksepp, J. (2002). Chronic intermittent amphetamine pretreatment enhances future appetitive behavior for drug- and natural-reward: Interaction with environmental variables. Behavior and Brain Research, 128, 189-203.
110. O'Brien, C. P. (2008). Evidence-based treatments of addiction. Philosophical Transactions of the Royal Society B, 363, 3277-3286.
111. Palfai, T. P. (2004). Automatic processes in self-regulation: Implications for alcohol interventions. Cognitive and Behavioral Practice, 11, 190-201.
112. Palfai, T. P. (2006). Automatic processes in the self-regulation of addictive behaviors. In R.W. Wiers & W. Stacy (Eds.), Handbook of implicit cognition and addictions (pp. 411-424). Thousand Oaks, CA: Sage.
113. Peciña, S., Smith, K. S., & Berridge, K. C. (2006). Hedonic hot spots in the brain. Neuroscientist, 12, 500-511.
114. Physician's Desk Reference (49th ed.). (1995). Montvale, NJ: Medical Economics Data Production.
115. Pohjalainen, T., Rinne, J. O., Nägren, K., Lehikoinen, P., Anttila, K., Syvälahti, E. K., & Hietala, J. (1998). The A1 allele of human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Molecular Psychiatry, 3, 256-260.
116. Porges, S. W. (2007). The polyvagal perspective. Biological Psychology, 72, 116-143.
117. Porges, S. W. (2009). The polyvagal theory: New insights into adaptive reactions of the autonomic nervous system. Cleveland Clinic Journal of Medicine, 76 (Suppl. 2), S86-S90.
118. Post, R. M., & Weiss, S. R. B. (1988). Sensitization and kindling: Implications for the evolution of psychiatric symptomatology. In P. W. Kalivas & C. D. Barnes (Eds.), Sensitization in the nervous system (pp. 257-291). Caldwell, NJ: Telford.
119. Potenza, M.N., Leung, H. C., Blumberg, H. P., Peterson, B. S., Fulbright, R. K., Lacadie, C. M., Gore, J. C. (2003). An fMRI Stroop task study of ventromedial prefrontal cortical function in pathological gamblers. American Journal of Psychiatry, 169, 1990-1994.
120. Pruessner, J. C., Champagne, F., Meaney, M. J., & Dagher, A. (2004). Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: A positron emission tomography study using [11C] raclopride. Journal of Neuroscience, 24, 2825-2831.
121. Robinson, T. E., & Berridge, K. C. (1993). The neural basis of drug craving: An incentive-sensitization theory of addiction. Brain Research Reviews, 18, 247-291.
122. Robinson, T. E., & Berridge, K. C. (2008). The incentive sensitization theory of addiction: Some current issues. Philosophical Transactions of the Royal Society B, 363, 3137-3146.
123. Roy, M., Roy, A., Williams, J., Weinberger, L., & Smelson, D. (1997). Reduced blue cone electroretinogram in cocaine-withdrawn patients. Archives of General Psychiatry, 54, 153-156.
124. Salamone, J. D., & Correa, M. (2002). Motivational views of reinforcement: Implications for understanding the behavioral functions of the nucleus accumbens dopamine. Behavioural Brain Research, 137, 3-25.
125. Salamone, J. D., Correa, M., Farrar, S., & Mingote, S. M. (2007). Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology, 191, 461-482.
126. Schmeichel, B. J., & Baumeister, R. F. (2004). Self-regulatory strength. In R. F. Baumeister & K. D. Vohs (Eds.), Handbook of self-regulation: Research, theory, and application (pp. 84-98). New York: Guilford.
127. Schulteis, G., & Koob, G. F. (1996). Reinforcement processes in opiate addiction: A homeostatic model. Neurochemical Research, 21, 1437-1454.
128. Segerstrom, S. C., & Solberg Nes, L. (2007). Heart rate variability reflects self-regulatory strength, effort, and fatigue. Psychological Science, 18, 275-281.
129. Shah, J. Y., Friedman, R. S., & Kruglanski, A. W. (2002). Forgetting all else: On the antecedents and consequences of goal shielding. Journal of Personality and Social Psychology, 83, 1261-1280.
130. Shipman, K., & Taussiq, H. (2009). Mental health treatment of child abuse and neglect: The promise of evidence-based practice. Pediatric Clinics of North America, 56, 417-428.
131. Simon, N. W., Mendex, I. A., & Setlow, B. (2007). Cocaine exposure causes long-term increases in impulsive choice. Behavioral Neuroscience, 121, 543-549.
132. Simpson, T. L., Kaysen, D., Bowen, S., MacPherson, L. M., Chawla, N., Blume, A., Larimer, M. (2007). PTSD symptoms, substance use and Vipassana meditation among incarcerated individuals. Journal of Traumatic Stress, 20, 239-249.
133. Smoller, J. W., Paulus, M. P., Fagerness, J. A., Purcell, S., Yamaki, L. H., Hirschfeld-Becker, D., Stein, M. B. (2008). Influence of RGS2 on anxiety-related temperament, personality, and brain function. Archives of General Psychiatry, 65, 298-308.
134. Stamey, W., & Jankovic, J. (2008). Impulse control disorders and pathological gambling in patients with Parkinson disease. Neurologist, 14, 89-99.
135. Szumlinski, K. K., Ary, A. W., & Lominac, K. D. (2008). Homers regulate druginduced neuroplasticity: Implications for addiction. Biochemical Pharmacology, 75, 112-133.
136. Tarter, R. E., Kirisci, L., Mezzich, A., Cornelius, J. R., Pajer, K., Vanyukov, M., Clark, D. (2003). Neurobehavioral disinhibition in childhood predicts early age onset of substance use disorder. American Journal of Psychiatry, 160, 1078-1085.
137. Tessari, M., Catalano, A., Pellitteri, M., Di Francesco, C., Marini, F., Gerrard, P. A., Melotto, S. (2007). Correlation between serum ghrelin levels and cocaine-seeking behavior triggered by cocaine-associated conditioned stimuli in rats. Addiction Biology, 12, 22-29.
138. Thayer, J. F. (2006). On the importance of inhibition: Central and peripheral manifestations of nonlinear inhibitory processes in neural systems. Dose-Response, 4, 2-21.
139. Thayer, J. F., & Lane, R. D. (2000). A model of neurovisceral integration in emotion regulation and dysregulation. Journal of Affective Disorder, 61, 201-216.
140. Tice, D. M., Baumeister, R. F., Shmueli, D., & Muraven, M. (2007). Restoring the self: Positive affect helps improve self-regulation following ego depletion. Journal of Experimental Social Psychology, 43, 379-384.
141. Verdejo-García, A. J., Lawrence, A. J., & Clark, L. (2008). Impulsivity as a vulnerability marker for substance-use disorders: Review of the findings from high-risk research, problem gamblers and genetic association studies. Neuroscience and Biobehavioral Reviews, 32, 777-810.
142. Verdejo-García, A. J., Perales, J. C., & Perez-García, M. (2007). Cognitive impulsivity in cocaine and heroin polysubstance abusers. Addictive Behavior, 32, 950-966.
143. Vohs, K. D., & Baumeister, R. F. (2004). Understanding self-regulation: An introduction. In R. F. Baumeister & K. D. Vohs (Eds.), Handbook of self-regulation: Research, theory, and application (pp. 1-12). New York: Guilford.
144. Volkow, N. D., Fowler, J. S., & Wang, G. J. (2004). The addicted human brain viewed in the light of imaging studies: Brain circuits and treatment strategies. Neuropharmacology, 47(Suppl. 1), 3-13.
145. Volkow, N. D., Fowler, J. S., Wang, G. J., Hitzemann, R., Logan, J., & Schlyer, D. J. (1993). Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abuse. Synapse, 14, 169-177.
146. Volkow, N. D., Wang, G. J., Fowler, J. S., Thanos, P. P., Logan, J., Gatley, S. J., Pappas, N. (2002). Brain DA D2 receptors predict reinforcing effects of stimulants in humans: Replication study. Synapse, 46, 79-82.
147. Volkow, N. D., Wang, G. J., Telang, F., Fowler, J. S., Logan, J., Childress, A. R., Wong, C. (2006). Cocaine cues and dopamine in dorsal striatum: Mechanisms of craving in cocaine addiction. Journal of Neuroscience, 26, 6583-6588.
148. Wade, T. R., de Wit, H., & Richards, J. B. (2000). Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats. Psychopharmacology, 150, 90-101.
149. Webb, T. L., & Sheeran, P. (2003). Can implementation intentions help to overcome ego-depletion? Journal of Experimental Social Psychology, 39, 279-286.
150. Williams, K. L., & Woods, J. H. (1999). Naltrexone reduces ethanoland/or water-reinforced responding in rhesus monkeys: Effect depends on ethanol concentration. Alcoholism: Clinical and Experimental Research, 23, 1462-1467.
151. Wise, R. A., & Bozarth, M. A. (1987). A psychomotor stimulant theory of addiction. Psychological Review, 94, 469-492.
152. Wise, R. A., & Rompre, P. P. (1989). Brain dopamine and reward. Annual Review of Psychology, 140, 191-225.
153. Yin, H. H., & Knowlton, B. J. (2006). Addiction and learning in the brain. In R.W. Wiers & W. Stacy (Eds.), Handbook of implicit cognition and addictions (pp. 167-184). Thousand Oaks, CA: Sage.
154. Zak, P. J., Kurban, R., & Matzner, W. T. (2004). The neurobiology of trust. Annals of the New York Academy of Sciences, 1032, 224-227.