Targeted genomic disruption of H-ras induces hypotension through a NO-cGMP-PKG pathway-dependent mechanism

Hypertension

Volumn 56, Issue 3, 2010, Pages 484-489

  Chamorro Jorganes, Aranzazu ^a,b   Grande, Maria Teresa ^b,c   Herranz, Beatriz ^a,b   Jerkic, Mirjana ^a,b,c,e   Griera, Mercedes ^b   Gonzalez Nuñez, Maria ^b,c   Santos, Eugenio ^c   Rodriguez Puyol, Diego ^a,b,d   Lopez Novoa, Jose Miguel ^b,c   Rodriguez Puyol, Manuel ^a,b  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b Instituto Reina Sofía de Investigaciones Nefrológicas   (Spain)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

arterial pressure; cGMP dependent protein kinase; cyclic GMP; H Ras protein; nitric oxide; soluble guanylyl cyclase

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE; NITRIC OXIDE; NITRITE; NITROPRUSSIDE SODIUM; PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA PRESSURE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENE DISRUPTION; GENE TARGETING; HYPOTENSION; MOUSE; NONHUMAN; ONCOGENE C H RAS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; SPHYGMOMANOMETRY; TELEMETRY; UPREGULATION; URINARY EXCRETION;

ANIMALS; AORTA; BLOOD PRESSURE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; FIBROBLASTS; GUANYLATE CYCLASE; HYPOTENSION; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; RAS PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; UP-REGULATION;

EID: 77955981809     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.110.152587     Document Type: Article

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