The power of the transmission disequilibrium test in the presence of population stratification

European Journal of Human Genetics

Volumn 18, Issue 9, 2010, Pages 1032-1038

  Sebro, Ronnie ^a,b   Rogus, John J ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JOSLIN DIABETES CENTER   (United States)

Author keywords

population stratification; power; Transmission Disequilibrium Test

Indexed keywords

ALLELE; ARTICLE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; POPULATION RESEARCH; PRIORITY JOURNAL; SAMPLE SIZE; TRANSMISSION DISEQUILIBRIUM TEST;

HETEROZYGOTE; HUMANS; LINKAGE DISEQUILIBRIUM;

EID: 77955980881     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2010.57     Document Type: Article

References (19)

1. Risch N, Merikangas K: The future of genetic studies of complex human diseases. Science 1996; 273: 1516-1518.
2. Devlin B, Roeder K, Bacanu SA: Unbiased methods for population-based association studies. Genet Epidemiol 2001; 21: 273-284.
3. Devlin B, Roeder K: Genomic control for association studies. Biometrics 1999; 55: 997-1004.
4. Knowler WC, Williams RC, Pettitt DJ, Steinberg AG: Gm3-5,13,14 and type-2 diabetes mellitus-an association in American-Indians with genetic admixture. Am J Hum Genet 1988; 43: 520-526.
5. Lander ES, Schork N: Genetic dissection of complex traits. Science 1994; 265: 2037-2048.
6. Pritchard JK, Donnelly P: Case-control studies of association in structured or admixed populations. Theor Popul Biol 2001; 60: 227-237.
7. Pritchard JK, Rosenberg NA: Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 1999; 65: 220-228.
8. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506-516.
9. Knapp M: A note on power approximations for the transmission/ disequilibrium test. Am J Hum Genet 1999; 64: 1177-1185.
10. Camp NJ: Genomewide transmission/disequilibrium testing-consideration of the genotypic relative risks at disease loci. Am J Hum Genet 1997; 61: 1424-1430.
11. Elandt-Johnson RC: Probability Models and Statistical Methods in Genetics. New York: Wiley, 1971.
12. Cavalli-Sforza LL, Menozzi P, Piazza A: The History and Geography of Human Genes. Princeton, NJ: Princeton University Press, 1994.
13. Akey JM, Zhang G, Zhang K, Jin L, Shriver MD: Interrogating a high-density SNP map for signatures of natural selection. Genome Res 2002; 12: 1805-1814.
14. Yasuda N: An extension of Wahlund's principle to evaluate mating type frequency. Am J Hum Genet 1968; 20: 1-23.
15. Risch N, Teng J: The relative power of family-based and case-control designs for association studies of complex human diseases. I. DNA pooling. Genome Res 1998; 8: 1273-1288.
16. Iles MM: On calculating the power of a TDT study-comparison of methods. Ann Hum Genet 2002; 66: 323-328.
17. Chen WM, Deng HW: A general and accurate approach for computing the statistical power of the transmission disequilibrium test for complex disease genes. Genet Epidemiol 2001; 21: 53-67.
18. Risch N: Searching for genetic determinants in the new millennium. Nature 2000; 405: 847-856.
19. Pritchard JK, Stephens M, Rosenberg NA, Donnelly P: Association mapping in structured populations. Am J Hum Genet 2000; 67: 170-181.