A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)

AAPS Journal

Volumn 12, Issue 3, 2010, Pages 385-396

  Omkvist, Diana Højmark ^a   Larsen, Simon Birksø ^b   Nielsen, Carsten Uhd ^a   Steffansen, Bente ^a   Olsen, Lars ^b   Jørgensen, Flemming Steen ^b   Brodin, Birger ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

FLIPR membrane potential assay; PEPT1 (SLC15A1); QSAR; translocation; tripeptides

Indexed keywords

ASPARTYLISOLEUCYLARGININE; METHIONYLPROLYLPROLINE; PEPTIDE TRANSPORTER 1; TRIPEPTIDE; UNCLASSIFIED DRUG; COTRANSPORTER; LIGAND; OLIGOPEPTIDE; PROTON; SLC15A1 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CELL ASSAY; CELL STRAIN; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; LIGAND BINDING; MOLECULAR MODEL; PREDICTION; PRINCIPAL COMPONENT ANALYSIS; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN TRANSPORT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DOG; HUMAN; MEMBRANE POTENTIAL; METABOLISM; SPECTROFLUOROMETRY;

ANIMALS; CELL LINE; DOGS; HUMANS; LIGANDS; MEMBRANE POTENTIALS; OLIGOPEPTIDES; PRINCIPAL COMPONENT ANALYSIS; PROTONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROMETRY, FLUORESCENCE; SYMPORTERS;

EID: 77955979549     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-010-9195-z     Document Type: Article

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