4-Aminomethylbenzoic acid is a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1

Journal of Physiology

Volumn 512, Issue 3, 1998, Pages 629-634

  Meredith, D ^a,d   Boyd, C A R ^a   Bronk, J R ^b   Bailey, P D ^c   Morgan, K M ^c   Collier, I D ^c   Temple, C S ^a,e  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c HERIOT WATT UNIVERSITY   (United Kingdom)

^d SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

^e ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOMETHYLBENZOIC ACID; CARRIER PROTEIN;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY TUBULE EPITHELIUM; MEMBRANE VESICLE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN TRANSPORT; RABBIT; XENOPUS LAEVIS;

4-AMINOBENZOIC ACID; ALGORITHMS; ANILINE COMPOUNDS; ANIMALS; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; KINETICS; MODELS, MOLECULAR; OOCYTES; PHENYLACETATES; RATS; RNA, MESSENGER; SYMPORTERS; XENOPUS LAEVIS;

EID: 0032213639     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.629bd.x     Document Type: Article

References (19)

1. BIBER, J., STIEGER, B., HAASE, W. & MURER, H. (1981). A high yield preparation for rat kidney brush border membranes. Different behaviour of lysosomal markers. Biochimica et Biophysica Acta 647, 169-176.
2. DANIEL, H. (1997). First insights into the operational mode of epithelial peptide transporters. Journal of Physiology 498, 561.
3. + symporter in the renal brush border membrane. Journal of Biological Chemistry 267, 9565-9573.
4. DEVES, R. & BOYD, C. A. R. (1989). The determination of kinetic parameters for carrier-mediated transport of non-labelled substrate analogues: a general method applied to the study of divalent anion transport in placental membrane vesicles. Proceedings of the Royal Society B 237, 85-97.
5. DEVES, R. & KRUPKA, R. M. (1979). The binding and translocation steps in transport as related to substrate structure. A study of the choline carrier of erythrocytes. Biochimica et Biophysica Acta 557, 469-485.
6. FEI, Y. J., GANAPATHY, V. & LEIBACH, F. H. (1998). Molecular and structural features of the proton-coupled oligopeptide transporter superfamily. Progress in Nucleic Acid Research 58, 239-261.
7. FEI, Y. J., KANAI, Y., NUSSBERGER, S., GANAPATHY, V., LEIBACH, F. H., ROMERO, M. F., SINGH, S. K., BORON, W. F. & HEDIGER, M. A. (1994). Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368, 563-566.
8. HEDIGER, M. A. & RHOADS, D. B. (1994). Molecular physiology of sodium-glucose cotransporters. Physiological Reviews 74, 993-1026.
9. LISTER, N., SYKES, A. P., BAILEY, P. D., BOYD, C. A. & BRONK, J. R. (1995). Dipeptide transport and hydrolysis in isolated loops of rat small intestine: effects of stereospecificity. Journal of Physiology 484, 173-82.
10. MATTHEWS, D. M. (1991). Protein Absorption: Development and Present State of the Subject. Wiley-Liss, New York.
11. MEREDITH, D., TEMPLE, C. S. & BOYD, C. A. R. (1996). Chemical evidence for the involvement of histidine residues in proton-peptide co-transport by PepT1 expressing Xenopus laevis oocytes. Journal of Physiology, 493.P, 65P.
12. MEREDITH, D., TEMPLE, C. S. & BOYD, C. A. R. (1998). Kinetic evidence that neutral and anionic peptides bind to different conformations of the recombinant epithelial peptide transporter PepT1. Journal of Physiology 506.P, 131P.
13. NAKAZAWA, F. (1922). The influence of phlorhizin on intestinal absorption. Tohoku Journal of Experimental Medicine 3, 288-295.
14. STEELE, A., NUSSBERGER, S., ROMERO, M. F., BORON, W. F., BOYD, C. A. R. & HEDIGER, M. A. (1997). Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepT1. Journal of Physiology 498, 568-569.
15. STEIN, W. D. (1990). Channel, Carriers and Pumps: an Introduction to Membrane Transport. Academic Press Inc., San Diego.
16. TEMPLE, C. S., BAILEY, P. D., BRONK, J. R. & BOYD, C. A. R. (1996). A model for the kinetics of neutral and anionic dipeptide-proton cotransport by the apical membrane of rat kidney cortex. Journal of Physiology 494, 795-808.
17. TEMPLE, C. S. & BOYD, C. A. R. (1998). Proton-coupled oligopeptide transport by rat renal cortical brush border membrane vesicles: a functional analysis using ACE inhibitors to determine the isoform of the transporter. Biochimica et Biophysica Acta 1373, 277-281.
18. TEMPLE, C. S., BRONK, J. R., BAILEY, P. D. & BOYD, C. A. R. (1995). Substrate-charge dependence of stoichiometry shows membrane potential is the driving force for proton-peptide cotransport in rat renal cortex. Pflügers Archiv 430, 825-829.
19. TEMPLE, C. S., STEWART, A. K., MEREDITH, D., LISTER, N. A., MORGAN, K. M., COLLIER, I. D., VAUGHAN JONES, R. D., BOYD, C. A. R., BAILEY, P. D. & BRONK, J. R. (1998). Peptide mimics as substrates for the intestinal peptide transporter. Journal of Biological Chemistry 273, 20-22.