Molecular mechanisms of innate immunity

Immunologic Research

Volumn 21, Issue 2-3, 2000, Pages 49-54

  Ulevitch, R J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Endotoxin; Receptors; Septic shock; Signal transduction

Indexed keywords

ENDOTOXIN; LIPOPOLYSACCHARIDE;

ARTICLE; CELL KILLING; CELLULAR IMMUNITY; HOST RESISTANCE; IMMUNE RESPONSE; MEDIATOR RELEASE; MOLECULAR CLONING; MOLECULAR RECOGNITION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SEPTIC SHOCK; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

EID: 0033843430     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:21:2-3:49     Document Type: Article

References (41)

1. Animal models of sepsis and shock: A review and lessons learned
2. Sepsis and septic shock
3. Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14
4. CD14 serves as the cellular receptor for complexes of lipopolysaccharide with lipopolysaccharide binding protein
5. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
6. Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin
7. Cell activation mediated by glycosylphosphatidylinositol-anchored or transmembrane forms of CD14
8. GPI-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin
9. Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein
10. Immune reactions in Drosophila and other insects: A model for innate immunity
11. Innate immunity: The virtues of a nonclonal system of recognition
12. The Toll-receptor family and control of innate immunity
13. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
14. A family of human receptors structurally related to Drosophila toll
15. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multigene receptor family in humans
16. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
17. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
18. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
19. Peptidoglycan-and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
20. Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
21. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
22. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
23. Cutting edge: Cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin
24. Defective LPS signalling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
25. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 Tlr4
26. Cutting edge: Functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: In vivo evidence for a dominant negative mutation
27. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
28. MyD88 is an adaptor protein in the hToll/IL1 receptor family signaling pathways
29. The interleukin-1 receptor: Ligand interactions and signal transduction
30. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
31. IRAK-M is a novel member of the Pelle/Interleukin-1 receptor-associated kinase (IRAK) family
32. Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase
33. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
34. Identification and characterization of a predominant isoform of human MKK3
35. Characterization of the structure and function of a novel MAP kinase kinase (MKK6)
36. The primary structure of p38gamma: A new member of p38 group of MAP kinase
37. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
38. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
39. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages
40. Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events