Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation

NeuroReport

Volumn 16, Issue 11, 2005, Pages 1157-1161

  Katsuki, Hiroshi ^a   Akaike, Akinori ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Excitotoxicity; Hypocretin; Hypothalamus; Narcolepsy; Neurodegeneration

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ARECAIDINE; BICUCULLINE; MUSCIMOL; NIPECOTIC ACID; NORADRENALIN; OREXIN; PICROTOXIN; QUINOLINIC ACID; SEROTONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; EXCITOTOXICITY; HYPOTHALAMUS; NARCOLEPSY; NERVE CELL DEGENERATION; NERVE CELL MEMBRANE POTENTIAL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; BICUCULLINE; CELL COUNT; CITALOPRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FLUOXETINE; GABA AGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAGNESIUM; NEURONS; NEUROPEPTIDES; NIPECOTIC ACIDS; NOREPINEPHRINE; ORGANOPHOSPHORUS COMPOUNDS; PICROTOXIN; QUINOLINIC ACID; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GABA-A; RECEPTORS, NEUROPEPTIDE; SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 23044492994     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200508010-00005     Document Type: Article

References (23)

1. Beuckmann CT, Yanagisawa M. Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation. J Mol Med 2002; 80:329-342.
2. Scammell TE. The neurobiology, diagnosis, and treatment of narcolepsy. Ann Neurol 2003; 53:154-166.
3. Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nature Med 2000; 6:991-997.
4. Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000; 27:469-474.
5. Katsuki H, Akaike A. Excitotoxic degeneration of hypothalamic orexin neurons in slice culture. Neurobiol Dis 2004; 15:61-69.
6. Li Y, Gao X-B, Sakurai T, van den Pol AN. Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron - a potential mechanism for orchestrating the hypothalamic arousal system. Neuron 2002; 36:1169-1181.
7. Eggermann E, Bayer L, Serafin M, Saint-Mleux B, Bernheim L, Machard D et al. The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization. J Neurosci 2003; 23:1557-1562.
8. Yamanaka A, Muraki Y, Tsujino N, Goto K, Sakurai T. Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem Biophys Res Commun 2003; 303:120-129.
9. Rosin DL, Weston MC, Sevigny CP, Stornetta RL, Guyenet PG. Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2. J Comp Neurol 2003; 465:593-603.
10. A receptor α subunit immunoreactivity in the rat hypothalamus: relationship with neurones containing orexigenic or anorexigenic peptides. J Neuroendocrinol 2004; 16:589-604.
11. 1A receptor. J Neurosci 2004; 24:7159-7166.
12. Li Y, van den Pol A. Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons. J Neurosci 2005; 25:173-183.
13. + currents is determined by G protein cycle. Am J Physiol Cell Physiol 2004; 287: C182-C191.
14. Bayer L, Eggermann E, Serafin M, Grivel J, Machard D, Muhlethaler M et al. Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices. Neuroscience 2005; 130:807-811.
15. A receptor activation attenuates excitotoxicity but exacerbates oxygen-glucose deprivation-induced neuronal injury in vitro. J Cereb Blood Flow Metab 1996; 16:1211-1218.
16. Ohkuma S, Chen SH, Katsura M, Chen DZ, Kuriyama K. Muscimol prevents neuronal injury by NMDA. Jpn J Pharmacol 1994; 64:125-128.
17. A receptor activation. Acta Neuropathol 1998; 95:592-596.
18. Erdo S, Michler A, Wolff JR. GABA accelerates excitotoxic cell death in cortical cultures: protection by blockers of GABA-gated chloride channels. Brain Res 1991; 542:254-258.
19. Vincent SR, Hokfelt T, Wu JY. GABA neuron systems in hypothalamus and the pituitary gland. Immunohistochemical demonstration using antibodies against glutamate decarboxylase. Neuroendocrinology 1982; 34:117-125.
20. Broberger C, de Lecea L, Sutcliffe JG, Hokfelt T. Hypocretin/orexin-and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol 1998; 402:460-474.
21. Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J et al. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 1998; 402:442-459.
22. Collin M, Backberg M, Ovesjo M-L, Fisone G, Edwards RH, Fujiyama F et al. Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight. Eur J Neurosci 2003; 18:1265-1278.
23. Gritti I, Mainville L, Jones BE. Projections of GABAergic and cholinergic basal forebrain and GABAergic preoptic-anterior hypothalamic neurons to the posterior lateral hypothalamus of the rat. J Comp Neurol 1994; 339:251-268.