IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells

Journal of Allergy and Clinical Immunology

Volumn 126, Issue 2, 2010, Pages

  Wadsworth, Samuel J ^a   Atsuta, Ryo ^b   McLntyre, J Oliver ^c   Hackett, Tillie Louise ^a   Singhera, Gurpreet K ^a   Dorscheid, Delbert R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b JUNTENDO UNIVERSITY   (Japan)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Airway epithelial cells; Asthma; Fas ligand; Immune barrier; Inflammation; Matrix metallo proteinase 7; Matrix metalloproteinase 3; TH2 cytokines

Indexed keywords

ADAM10 ENDOPEPTIDASE; FAS LIGAND; GELATINASE A; GELATINASE B; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 9; MATRILYSIN; MESSENGER RNA; SMALL INTERFERING RNA; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; FAS ANTIGEN; FAS PROTEIN, HUMAN; IL4 PROTEIN, HUMAN; IL9 PROTEIN, HUMAN; MMP7 PROTEIN, HUMAN;

ADULT; AIRWAY EPITHELIUM CELL; ARTICLE; ASTHMA; BRONCHUS EPITHELIUM; CELLULAR DISTRIBUTION; CHILD; CILIATED EPITHELIUM CELL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; ENZYME ACTIVITY; EPITHELIUM BASAL CELL; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG PARENCHYMA; PRIMARY CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA INTERFERENCE; TH2 CELL; BIOLOGICAL MODEL; BIOSYNTHESIS; BRONCHUS; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; RESPIRATORY TRACT MUCOSA;

ANTIGENS, CD95; ASTHMA; BRONCHI; CELL LINE, TRANSFORMED; EPITHELIAL CELLS; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-9; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASE 9; MODELS, BIOLOGICAL; RESPIRATORY MUCOSA; RNA, SMALL INTERFERING; TH2 CELLS;

EID: 77955896050     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.05.015     Document Type: Article

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