Age-related deregulation of Aire and peripheral tissue antigen genes in the thymic stroma of non-obese diabetic (NOD) mice is associated with autoimmune type 1 diabetes mellitus (DM-1)

Molecular and Cellular Biochemistry

Volumn 342, Issue 1-2, 2010, Pages 21-28

  Fornari, Thaís A ^a   Donate, Paula B ^a   MacEdo, Claudia ^a   Marques, Márcia M C ^a   Magalhães, Danielle A ^a   Passos, Geraldo A S ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Disciplines of Genetics and Molecular Biology   (Brazil)

Author keywords

Aire gene; Chronological gene expression; Non obese diabetic (NOD); Thymic stromal cells; Type 1 diabetes mellitus

Indexed keywords

GLUTAMATE DECARBOXYLASE 67; TISSUE ANTIGEN;

AIRE GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENOTYPE; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; REAL TIME POLYMERASE CHAIN REACTION; THYMUS;

AGING; ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; BIOLOGICAL MARKERS; BLOTTING, WESTERN; COLLAGEN TYPE II; DIABETES MELLITUS, TYPE 1; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUTAMATE DECARBOXYLASE; IMMUNOENZYME TECHNIQUES; MICE; MICE, INBRED NOD; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMUS GLAND; TRANSCRIPTION FACTORS;

ANIMALIA; MUS;

EID: 77955851319     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0464-z     Document Type: Article

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