Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in plasma, urine, bile, intestinal contents, faeces and eight selected tissues from mice

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 25, 2010, Pages 2353-2362

  Teunissen, S F ^a   Vlaming, M L H ^a   Rosing, H ^a   Schellens, J H M ^a   Schinkel, A H ^a   Beijnen, J H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Heterocyclic amines; Liquid chromatography; Matrix effects; Metabolites; Mice; N OH PhIP; PhIP; Tandem mass spectrometry; Tissue

Indexed keywords

HETEROCYCLIC AMINES; MATRIX EFFECTS; MICE; N-OH-PHIP; PHIP; TANDEM MASS SPECTROMETRY;

ACETONITRILE; AMINATION; AMINES; BIOMOLECULES; CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PRECIPITATION (CHEMICAL); PYRIDINE; TISSUE;

BODY FLUIDS;

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 HYDROXYAMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; DRUG METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG STRUCTURE; DRUG URINE LEVEL; FECES LEVEL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; STOMACH JUICE; TANDEM MASS SPECTROMETRY;

ACETONITRILES; ANIMALS; BODILY SECRETIONS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIGESTIVE SYSTEM; DRUG STABILITY; FECES; HUMANS; IMIDAZOLES; LINEAR MODELS; MICE; PYRIDINES; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

MUS;

EID: 77955842509     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.07.012     Document Type: Article

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