Stem/Precursor Cell-Based CNS Therapy: The Importance of Circumventing Immune Suppression by Transplanting Autologous Cells

Stem Cell Reviews and Reports

Volumn 6, Issue 3, 2010, Pages 405-410

  Kulbatski, Iris ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Autologous; Bone marrow stromal cells; Central nervous system; Immunomodulation; Immunosuppresion; Neural repair; Neurodegeneration; Neurotrauma; Stem precursor cells; Transplantation

Indexed keywords

ANIMAL; ARTICLE; AUTOTRANSPLANTATION; BIOLOGICAL MODEL; CENTRAL NERVOUS SYSTEM DISEASE; HISTOCOMPATIBILITY; HUMAN; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; METHODOLOGY; PHYSIOLOGY; STEM CELL TRANSPLANTATION;

ANIMALS; CENTRAL NERVOUS SYSTEM DISEASES; HUMANS; IMMUNOSUPPRESSION; MODELS, BIOLOGICAL; STEM CELL TRANSPLANTATION; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, AUTOLOGOUS;

EID: 77955834363     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-010-9141-6     Document Type: Article

References (77)

1. Mathews, D. J., Sugarman, J., Bok, H., et al. (2008). Cell-based interventions for neurologic conditions: ethical challenges for early human trials. Neurology, 71(4), 288-293.
2. Hyun, I., Lindvall, O., Ahrlund-Richter, L., et al. (2008). New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell, 3(6), 607-609.
3. Kulbatski, I., Mothe, A. J., Nomura, H., & Tator, C. H. (2005). Endogenous and exogenous CNS derived stem/progenitor cell approaches for neurotrauma. Current Drug Targets, 6(1), 111-126.
4. Parr, A. M., Tator, C. H., & Keating, A. (2007). Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury. Bone Marrow Transplantation, 40(7), 609-619.
5. Zhang, S. C. (2003). Embryonic stem cells for neural replacement therapy: prospects and challenges. Journal of Hematotherapy and Stem Cell Research, 12(6), 625-634.
6. McDonald, J. W., Becker, D., Holekamp, T. F., et al. (2004). Repair of the injured spinal cord and the potential of embryonic stem cell transplantation. Journal of Neurotrauma, 21(4), 383-393.
7. Horner, P. J., Power, A. E., Kempermann, G., et al. (2000). Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. Journal of Neuroscience, 20(6), 2218-2228.
8. Johansson, C. B., Momma, S., Clarke, D. L., Risling, M., Lendahl, U., & Frisen, J. (1999). Identification of a neural stem cell in the adult mammalian central nervous system. Cell, 96(1), 25-34.
9. Johansson, C. B., Svensson, M., Wallstedt, L., Janson, A. M., & Frisén, J. (1999). Neural stem cells in the adult human brain. Experimental Cell Research, 253(2), 733-736.
10. Namiki, J., & Tator, C. H. (1999). Cell proliferation and nestin expression in the ependyma of the adult rat spinal cord after injury. Journal of Neuropathology and Experimental Neurology, 58(5), 489-498.
11. Temple, S., & Alvarez-Buylla, A. (1999). Stem cells in the adult mammalian central nervous system. Current Opinion in Neurobiology, 9(1), 135-141.
12. Weiss, S., Dunne, C., Hewson, J., et al. (1996). Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. Journal of Neuroscience, 16(23), 7599-7609.
13. Shihabuddin, L. S., Horner, P. J., Ray, J., & Gage, F. H. (2000). Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. Journal of Neuroscience, 20(23), 8727-8735.
14. Suhonen, J. O., Peterson, D. A., Ray, J., & Gage, F. H. (1996). Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature, 383(6601), 624-627.
15. Cao, Q. L., Zhang, Y. P., Howard, R. M., Walters, W. M., Tsoulfas, P., & Whittemore, S. R. (2001). Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage. Experimental Neurology, 167(1), 48-58.
16. Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. (2007). Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nature Neuroscience, 10(12), 1538-1543.
17. Butovsky, O., Kunis, G., Koronyo-Hamaoui, M., & Schwartz, M. (2007). Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. European Journal of Neuroscience, 26, 413-416.
18. Linington, C., Berger, T., Perry, L., et al. (1993). T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. European Journal of Immunology, 23(6), 1364-1372.
19. Malm, T. M., Koistinaho, M., Parepalo, M., et al. (2005). Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. Neurobiology of Disease, 18(1), 134-142.
20. Mildner, A., Schmidt, H., Nitsche, M., et al. (2007). Microglia in the adult brain arise from Ly-6ChiCCR2+monocytes only under defined host conditions. Nature Neuroscience, 10(12), 1544-1553.
21. Schwartz, M., & Moalem, G. (2001). Beneficial immune activity after CNS injury: prospects for vaccination. Journal of Neuroimmunology, 113, 185-192.
22. Simard, A. R., Soulet, D., Gowing, G., Julien, J. P., & Rivest, S. (2006). Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron, 49, 489-502.
23. Ziv, Y., Avidan, H., Pluchino, S., Martino, G., & Schwartz, M. (2006). Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proceedings of the National Academy of Sciences of the United States of America, 103, 13174-13179.
24. Ziv, Y., Ron, N., Butovsky, O., et al. (2006). Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nature Neuroscience, 9(2), 268-275.
25. Beers, D. R., Henkel, J. S., Zhao, W., Wang, J., & Appel, S. H. (2008). CD4+T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proceedings of the National Academy of Sciences of the United States of America, 105, 15558-15563.
26. Chiu, I. M., Chen, A., Zheng, Y., et al. (2008). T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proceedings of the National Academy of Sciences of the United States of America, 105, 17913-17918.
27. Popovich, P. G., Guan, Z., Wei, P., Huitinga, I., van Rooijen, N., & Stokes, B. T. (1999). Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Experimental Neurology, 158(2), 351-365.
28. Stirling, D. P., Khodarahmi, K., Liu, J., et al. (2004). Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. Journal of Neuroscience, 24(9), 2182-2190.
29. Moalem, G., Leibowitz-Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999). Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nature Medicine, 5(1), 49-55.
30. Bechmann, I., & Nitsch, R. (2001). Plasticity following lesion: help and harm from the immune system. Restorative Neurology and Neuroscience, 19, 189-198.
31. Hofstetter, H. H., Sewell, D. L., Liu, F., et al. (2003). Autoreactive T cells promote post-traumatic healing in the central nervous system. Journal of Neuroimmunology, 134(1-2), 25-34.
32. Gris, D., Marsh, D. R., Oatway, M. A., et al. (2004). Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function. Journal of Neuroscience, 24(16), 4043-4051.
33. Mabon, P. J., Weaver, L. C., & Dekaban, G. A. (2000). Inhibition of monocyte/macrophage migration to a spinal cord injury site by an antibody to the integrin alphaD: a potential new anti-inflammatory treatment. Experimental Neurology, 166, 52-64.
34. Popovich, P. G., & Hickey, W. F. (2001). Bone marrow chimeric rats reveal the unique distribution of resident and recruited macrophages in the contused rat spinal cord. Journal of Neuropathology and Experimental Neurology, 60, 676-685.
35. Popovich, P. G., Guan, Z., McGaughy, V., Fisher, L., Hickey, W. F., & Basso, D. M. (2002). The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation. Journal of Neuropathology and Experimental Neurology, 61(7), 623-633.
36. Meda, L., Cassatella, M. A., Szendrei, G. I., et al. (1995). Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature, 374(6523), 647-650.
37. Majed, H. H., Chandran, S., Niclou, S. P., et al. (2006). A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. Journal of Neuroscience, 26(6), 1730-1738.
38. Block, M. I., Zecca, L., & Hong, J. S. (2007). Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Reviews. Neuroscience, 8, 57-69.
39. Chao, C. C., Hu, S., Molitor, T. W., Shaskan, E. G., & Peterson, P. K. (1992). Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. Journal of Immunology, 149, 2736-2741.
40. Leon, S., Yin, Y., Nguyen, J., Irwin, N., & Benowitz, L. I. (2000). Lens injury stimulates axon regeneration in the mature rat optic nerve. Journal of Neuroscience, 20, 4615-4626.
41. Glezer, I., Simard, A. R., & Rivest, S. (2007). Neuroprotective role of the innate immune system by microglia. Neuroscience, 147, 867-883.
42. Neumann, J., Gunzer, M., Gutzeit, H. O., Ullrich, O., Reymann, K. G., & Dinkel, K. (2006). Microglia provide neuroprotection after ischemia. FASEB Journal, 20(6), 714-716.
43. Simard, A. R., Soulet, D., Gowing, G., Julien, J. P., & Rivest, S. (2006). Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron, 49, 489-502.
44. Polazzi, E., Gianni, T., & Contestabile, A. (2001). Microglial cells protect cerebellar granule neurons from apoptosis: evidence for reciprocal signaling. Glia, 36, 271-280.
45. Rapalino, O., Lazarov-Spiegler, O., Agranov, E., et al. (1998). Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nature Medicine, 4(7), 814-821.
46. Ben-Hur, T. (2008). Immunomodulation by neural stem cells. Journal of the Neurological Sciences, 265, 102-104.
47. Karussis, D., Kassis, I., Kurkalli, B. G., & Slavin, S. (2008). Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): a proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases. Journal of the Neurological Sciences, 265(1-2), 131-135.
48. Ting, A. E., Mays, R. W., Frey, M. R., Van't Hof, W., Medicetty, S., & Deans, R. (2008). Therapeutic pathways of adult stem cell repair. Critical Reviews in Oncology/hematology, 65(1), 81-93.
49. Ben-Hur, T., Ben-Menachem, O., Furer, V., Einstein, O., Mizrachi-Kol, R., & Grigoriadis, N. (2003). Effects of proinflammatory cytokines on growth, fate, and motility of multipotential neural precursor cell. Molecular and Cellular Neurosciences, 24, 623-631.
50. Belmadani, A., Tran, P. B., Ren, D., & Miller, R. J. (2006). Chemokines regulate the migration of neural progenitors to sites of neuroinflammation. Journal of Neuroscience, 26, 3182-3191.
51. Lalive, P. H., Paglinawan, R., Biollaz, G., et al. (2005). TGF-beta-treated microglia induce oligodendrocyte precursor cell chemotaxis through the HGF-c-Met pathway. European Journal of Immunology, 35, 727-737.
52. Armstrong, R. C., Harvath, L., & Dubois-Dalcq, M. E. (1990). Type 1 astrocytes and oligodendrocyte-type 2 astrocyte glial progenitors migrate toward distinct molecules. Journal of Neuroscience Research, 27, 400-407.
53. Imitola, J., Raddassi, K., Park, K. I., et al. (2003). Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proceedings of the National Academy of Sciences of the United States of America, 101, 18117-18122.
54. Nasef, A., Ashammakhi, N., & Fouillard, L. (2008). Immunomodulatory effect of mesenchymal stromal cells: possible mechanisms. Regeneración Médica, 3(4), 531-46.
55. Einstein, O., Fainstein, N., Vaknin, I., et al. (2007). Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression. Annals of Neurology, 61, 209-218.
56. Zappia, E., Casazza, S., Pedemonte, E., et al. (2005). Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood, 106, 1755-1761.
57. Aggarwal, S., & Pittenger, M. F. (2005). Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood, 105, 1815-1822.
58. Le Blanc, K., Rasmusson, I., Gotherstrom, C., et al. (2004). Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes. Scandinavian Journal of Immunology, 60, 307-315.
59. Smyth, M. J., Dunn, G. P., & Schreiber, R. D. (2006). Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity. Advances in Immunology, 90, 1-50.
60. Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., & Schreiber, R. D. (2002). Cancer immunoediting: from immunosurveillance to tumor escape. Nature Immunology, 3(11), 991-998.
61. Schwartz, M., & Ziv, Y. (2008). Immunity to self and self-maintenance: what can tumor immunology teach us about ALS and Alzheimer's disease? Trends in Pharmacological Sciences, 29(6), 287-293.
62. Baker, M. (2009). Tumors spark stem-cell review. Nature, 457(7232), 941.
63. Amariglio, N., Hirshberg, A., Scheithauer, B. W., et al. (2009). Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Medicine, 6(2), e1000029.
64. Lee, H., Park, J., Forget, B. G., & Gaines, P. (2009). Induced pluripotent stem cells in regenerative medicine: an argument for continued research on human embryonic stem cells. Regeneración Médica, 4(5), 759-769.
65. Rolletschek, A., & Wobus, A. M. (2009). Induced human pluripotent stem cells: promises and open questions. Biological Chemistry, 390(9), 845-849.
66. Jalving, M., & Shepers, H. (2009). Induced pluripotent stem cells: will they be safe? Current Opinion in Molecular Therapeutics, 11(4), 383-393.
67. Mahmood, A., Lu, D., Lu, M., & Chopp, M. (2003). Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery, 53, 697-702.
68. Mahmood, A., Lu, D., Qu, C., Goussev, A., & Chopp, M. (2005). Human marrow stromal cell treatment provides long-lasting benefit after traumatic brain injury in rats. Neurosurgery, 57, 1026-1031. discussion 1026-1031.
69. Zhang, J., Li, Y., Chen, J., et al. (2005). Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice. Experimental Neurology, 195, 16-26.
70. Uccelli, A., Zappia, E., Benvenuto, F., Frassoni, F., & Mancardi, G. (2006). Stem cells in inflammatory demyelinating disorders: a dual role for immunosuppression and neuroprotection. Expert Opinion on Biological Therapy, 6, 17-22.
71. Mansilla, E., Marin, G. H., Sturla, F., et al. (2005). Human mesenchymal stem cells are tolerized by mice and improve skin and spinal cord injuries. Transplantation Proceedings, 37, 292-294.
72. Syková, E., Homola, A., Mazanec, R., et al. (2006). Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury. Cell Transplantation, 15, 675-687.
73. Himes, B. T., Neuhuber, B., Coleman, C., et al. (2006). Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord. Neurorehabil Neural Repair, 20, 278-296.
74. Park, H. C., Shim, Y. S., Ha, Y., et al. (2005). Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor. Tissue Engineering, 11, 913-922.
75. Li, Y., & Chopp, M. (2009). Marrow stromal cell transplantation in stroke and traumatic brain injury. Neuroscience Letters, 456(3), 120-123.
76. Slavin, S., Kurkalli, B. G., & Karussis, D. (2008). The potential use of adult stem cells for the treatment of multiple sclerosis and other neurodegenerative disorders. Clinical Neurology and Neurosurgery, 110(9), 943-946.
77. Tator, C. H. (2006). Review of treatment trials in human spinal cord injury: issues, difficulties, and recommendations. Neurosurgery, 59, 957-982. discussion 982-987.