FGF21 is dispensable for hypothermia induced by fasting in mice

Neuroendocrinology Letters

Volumn 31, Issue 2, 2010, Pages 198-202

  Oishi, Katsutaka ^a   Sakamoto, Katsuhiko ^a   Konishi, Morichika ^b   Murata, Yusuke ^b   Itoh, Nobuyuki ^b   Sei, Hiroyoshi ^c  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Body temperature; Circadian rhythm; Ketosis; Neuropeptide Y; Peroxisome proliferator activated receptor a; Starvation; Torpor

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 12; MESSENGER RNA; NEUROPEPTIDE Y; UNCLASSIFIED DRUG; FIBROBLAST GROWTH FACTOR 21;

ADAPTATION; ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; BODY TEMPERATURE MONITORING; CONTROLLED STUDY; DIET RESTRICTION; GENE EXPRESSION; GENOTYPE; HYPOTHALAMUS; KETOGENIC DIET; LOCOMOTION; MALE; MOUSE; NONHUMAN; PHYSIOLOGICAL HYPOTHERMIA; PHYSIOLOGICAL PROCESS; PROTEIN EXPRESSION; THERMOREGULATION; WILD TYPE; ANIMAL; C57BL MOUSE; DEFICIENCY; GENETICS; HYPOTHERMIA; KNOCKOUT MOUSE; LIVER; METABOLISM; MOTOR ACTIVITY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BODY TEMPERATURE; FASTING; FIBROBLAST GROWTH FACTORS; HYPOTHALAMUS; HYPOTHERMIA; KETOGENIC DIET; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NEUROPEPTIDE Y; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 77952347202     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Astrup A, Meinert Larsen T, Harper A. (2004). Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss? Lancet. 364: 897-899.
2. Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E. (2009). Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology. 150: 4931-4940.
3. Chikahisa S, Tominaga K, Kawai T, Kitaoka K, Oishi K, Ishida N, Rokutan K, Sei H. (2008). Bezafibrate, a peroxisome proliferator-activated receptors agonist, decreases body temperature and enhances electroencephalogram delta-oscillation during sleep in mice. Endocrinology. 149: 5262-5271.
4. Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE, Kharitonenkov A. (2008). Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 149: 6018-6027.
5. Hotta Y, Nakamura H, Konishi M, Murata Y, Takagi H, Matsumura S, Inoue K, Fushiki T, Itoh N. (2009). Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology. 150: 4625-4633.
6. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA. (2007). Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 5: 415-425.
7. Itoh N, Ornitz DM. (2004). Evolution of the Fgf and Fgfr gene families. Trends Genet. 20: 563-569. (Pubitemid 39314564)
8. Kharitonenkov A, Shanafelt AB. (2008). Fibroblast growth factor-21 as a therapeutic agent for metabolic diseases. BioDrugs. 22: 37-44. (Pubitemid 351158533)
9. Melvin RG., Andrews MT. (2009) Torpor induction in mammals: recent discoveries fueling new ideas. Trends Endocrinol Metab. 20(10): 490-498.
10. Nelson CJ, Otis JP, Carey HV. (2009). A role for nuclear receptors in mammalian hibernation. J Physiol. 587: 1863-1870.
11. Oishi K, Uchida D, Ishida N. (2008). Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver. FEBS Lett. 582: 3639-3642.
12. Oishi K, Uchida D, Ohkura N, Doi R, Ishida N, Kadota K, Horie S. (2009). Ketogenic diet disrupts the circadian clock and increases hypofibrinolytic risk by inducing expression of plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol. 29: 1571-1577.