Differential effects of Phe19 and Phe20 on fibril formation by amyloidogenic peptide Aβ16-22 (Ac-KLVFFAE-NH2)

Proteins: Structure, Function and Bioinformatics

Volumn 78, Issue 10, 2010, Pages 2306-2321

  Inouye, Hideyo ^a,d   Gleason, Katherine A ^a   Zhang, Dong ^b   Decatur, Sean M ^b,c   Kirschner, Daniel A ^a  

^a BOSTON COLLEGE   (United States)

^b MOUNT HOLYOKE COLLEGE   (United States)

^c OBERLIN COLLEGE   (United States)

^d RIGAKU CORPORATION   (Japan)

Author keywords

Alzheimer's disease; Amyloid inhibitor; Infrared spectroscopy; Nitrile probes; Protein folding; X ray diffraction

Indexed keywords

AMINO ACID DERIVATIVE; AMYLOID BETA PROTEIN; NITRILE; PHENYLALANINE; ALANINE; AMYLOID; AMYLOID BETA-PROTEIN (16-22); NERVE PROTEIN; OLIGOPEPTIDE; P-CYANOPHENYLALANINE; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; FIBER; HYDROGEN BOND; HYDROPHILICITY; INFRARED SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN FOLDING; X RAY POWDER DIFFRACTION; AMINO ACID SUBSTITUTION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; FREEZE DRYING; HUMAN; INFRARED SPECTROPHOTOMETRY; METABOLISM; MOLECULAR DYNAMICS; POWDER DIFFRACTION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SOLUBILITY; SURFACE PROPERTY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ALANINE; AMINO ACID SUBSTITUTION; AMYLOID; AMYLOID BETA-PEPTIDES; CRYSTALLOGRAPHY, X-RAY; FREEZE DRYING; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NERVE TISSUE PROTEINS; NITRILES; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PHENYLALANINE; POWDER DIFFRACTION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED; SURFACE PROPERTIES;

EID: 77955785224     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22743     Document Type: Article

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