Comment concerning the article: 'Phytanic acid impairs mitochondrial respiration through protonophoric action' by Komen et al.: Branched chain phytanic acid inhibits the activity of the mitochondrial respiratory chain

Cellular and Molecular Life Sciences

Volumn 65, Issue 14, 2008, Pages 2266-2269

  Schonfeld P ^a   Reiser, G ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUTAMIC ACID; MALIC ACID; MITOCHONDRIAL DNA; PHYTANIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ASTROCYTE; CYTOPATHOGENIC EFFECT; ELECTRON TRANSPORT; LETTER; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; NEUROTOXICITY; NONHUMAN; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; REFSUM DISEASE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ELECTRON TRANSPORT; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHYTANIC ACID; PROTONS;

EID: 47749129576     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-008-8117-z     Document Type: Letter

References (17)

1. Komen, J. C., Distelmaier, F., Koopman, W. J., Wanders, R. J., Smeitink, J. and Willems, P. H. (2007) Phytanic acid impairs mitochondrial respiration through protonophoric action. Cell. Mol. Life Sci. 64, 3271-3281.
2. Wanders, R. J. and Komen, J. C. (2007) Peroxisomes, Refsum's disease and the α- and ω-oxidation of phytanic acid. Biochem. Soc. Trans. 35, 865-869.
3. 2+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal astrocytes. Neurobiol. Dis. 18, 110-118.
4. Schönfeld, P. and Bohnensack, R. (1997) Fatty acid-promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier. FEBS Lett. 420, 167-170.
5. Schönfeld, P., Kahlert, S. and Reiser, G. (2004) In brain mitochondria the branched-chain fatty acid phytanic acid impairs energy transduction and sensitizes for permeability transition. Biochem. J. 383, 121-128.
6. Schönfeld, P. and Reiser, G. (2006) Rotenone-like action of the branched-chain phytanic acid induces oxidative stress in mitochondria. J. Biol. Chem. 281, 7136-7142.
7. Schönfeld, P. and Wojtczak, L. (2007) Fatty acids decrease mitochondrial generation of reactive oxygen species at the reverse electron transport but increase it at the forward transport. Biochim. Biophys. Acta 1767, 1032-1040.
8. Latruffe, N. (1987) Transport of D-beta-hydroxybutyrate across rat liver mitochondrial membranes. Comp. Biochem. Physiol. B 88, 797-802.
9. McIntyre, J. O., Bock, H. G. and Fleischer, S. (1978) The orientation of D-beta-hydroxybutyrate dehydrogenase in the mitochondrial inner membrane. Biochim. Biophys. Acta 513, 255-267.
10. Cocco, T., Di Paola, M., Papa, S. and Lorusso, M. (1999) Arachidonic acid interaction with the mitochondrial electron transport chain promotes reactive oxygen species generation. Free Radic. Biol. Med. 27, 51-59.
11. Reiser, G., Schönfeld, P. and Kahlert, S. (2006) Mechanism of toxicity of the branched-chain fatty acid phytanic acid, a marker of Refsum disease, in astrocytes involves mitochondrial impairment. Int. J. Dev. Neurosci. 24, 113-122.
12. Schönfeld, P., Kahlert, S. and Reiser, G. (2006) A study of the cytotoxicity of branched-chain phytanic acid with mitochondria and rat brain astrocytes. Exp. Gerontol. 41, 688-696.
13. Takeuchi, Y., Morii, H., Tamura, M., Hayaishi, O. and Watanabe, Y. (1991) A possible mechanism of mitochondrial dysfunction during cerebral ischemia: inhibition of mitochondrial respiration activity by arachidonic acid. Arch. Biochem. Biophys. 289, 33-38.
14. Loskovich, M. V., Grivennikova, V. G., Cecchini, G. and Vinogradov, A. D. (2005) Inhibitory effect of palmitate on the mitochondrial NADH:ubiquinone oxidoreductase (complex I) as related to the active-de-active enzyme transition. Biochem. J. 387, 677-683.
15. Chan, P. H., Chen, S. F. and Yu, A. C. (1988) Induction of intracellular superoxide radical formation by arachidonic acid and by polyunsaturated fatty acids in primary astrocytic cultures. J. Neurochem. 50, 1185-1193.
16. Giulivi, C., Boveris, A. and Cadenas, E. (1995) Hydroxyl radical generation during mitochondrial electron transfer and the formation of 8-hydroxydesoxyguanosine in mitochondrial DNA. Arch. Biochem. Biophys. 316, 909-916.
17. Williamson, D. H., Mellanby, J. and Krebs, H. A. (1962) Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood. Biochem. J. 82, 90-96.