G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning G protein-coupled receptors

Pharmacology

Volumn 86, Issue 1, 2010, Pages 22-29

  Moser, Elisabeth ^a   Kargl, Julia ^a   Whistler, Jennifer L ^b   Waldhoer, Maria ^a   Tschische, Pia ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

Author keywords

Adaptor protein; Degradation; G protein coupled receptor associated sorting protein 1; G protein coupled receptor associated sorting protein 2; Postendocytic receptor sorting; Receptor, downregulation; Seven transmembrane domain G protein coupled receptor; Trafficking

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR ASSOCIATED SORTING PROTEIN 1; G PROTEIN COUPLED RECEPTOR ASSOCIATED SORTING PROTEIN 2; SEVEN TRANSMEMBRANE SPANNING G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG;

CELL SELECTION; ENDOCYTOSIS; HUMAN; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; DOWN-REGULATION; ENDOCYTOSIS; HUMANS; LYSOSOMES; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; VESICULAR TRANSPORT PROTEINS;

EID: 77955706561     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000314161     Document Type: Review

References (53)

1. Klabunde T, Hessler G: Drug design strategies for targeting G protein-coupled receptors. Chembiochem 2002; 3: 928-944.
2. Gether U: Uncovering molecular mechanisms involved in activation of G proteincoupled receptors. Endocr Rev 2000; 21: 90-113.
3. Claing A, Laporte SA, Caron MG, Lefkowitz RJ: Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol 2002; 66: 61-79.
4. Hinrichsen L, Meyerholz A, Groos S, Ungewickell EJ: Bending a membrane: how clathrin affects budding. Proc Natl Acad Sci USA 2006; 103: 8715-8720.
5. Wolfe BL, Trejo J: Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis. Traffic 2007; 8: 462-470.
6. Tsao P, Cao T, von Zastrow M: Role of endocytosis in mediating downregulation of G protein-coupled receptors. Trends Pharmacol Sci 2001; 22: 91-96.
7. Whistler JL, Enquist J, Marley A, et al: Modulation of postendocytic sorting of G protein- coupled receptors. Science 2002; 297: 615-620.
8. Premont RT, Gainetdinov RR: Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol 2007; 69: 511-534.
9. Reiter E, Lefkowitz RJ: GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 2006; 17: 159-165.
10. Ferguson SS, Zhang J, Barak LS, Caron MG: Molecular mechanisms of G protein-coupled receptor desensitization and resensitization. Life Sci 1998; 62: 1561-1565.
11. Cao TT, Deacon HW, Reczek D, Bretscher A, von Zastrow M: A kinase-regulated PDZ-domain interaction controls endocytic sorting of the- 2 -adrenergic receptor. Nature 1999; 401: 286-290.
12. Marchese A, Benovic JL: Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem 2001; 276: 45509-45512.
13. Mukhopadhyay D, Riezman H: Proteasomeindependent functions of ubiquitin in endocytosis and signaling. Science 2007; 315: 201-205.
14. Traub LM, Lukacs GL: Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPs. J Cell Sci 2007; 120(pt 4):543-553.
15. Levkowitz G, Waterman H, Zamir E, et al: c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev 1998; 12: 3663-3674.
16. Gage RM, Kim KA, Cao TT, von Zastrow M: A transplantable sorting signal that is sufficient to mediate rapid recycling of G proteincoupled receptors. J Biol Chem 2001; 276: 44712-44720.
17. Hanyaloglu AC, McCullagh E, von Zastrow M: Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling. EMBO J 2005; 24: 2265-2283.
18. Hanyaloglu AC, von Zastrow M: A novel sorting sequence in the- 2 - adrenergic receptor switches recycling from default to the Hrs-dependent mechanism. J Biol Chem 2007; 282: 3095-3104.
19. Wang Y, Lauffer B, von Zastrow M, Kobilka B, Xiang Y: NSF regulates- 2 -adrenoceptors trafficking and signaling in cardiomyocytes. Mol Pharmacol 2007; 72: 429-439.
20. Brady AE, Limbird LE: G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction. Cell Signal 2002; 14: 297-309.
21. Bockaert J, Fagni L, Dumuis A, Marin P: GPCR interacting proteins (GIP). Pharmacol Ther 2004; 103: 203-221.
22. Bilodeau PS, Urbanowski JL, Winistorfer SC, Piper RC: The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting. Nat Cell Biol 2002; 4: 534-539.
23. Babst M, Odorizzi G, Estepa EJ, Emr SD: Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic 2000; 1: 248-258.
24. Maxfield FR, McGraw TE: Endocytic recycling. Nat Rev Mol Cell Biol 2004; 5: 121-132.
25. Hanyaloglu AC, von Zastrow M: Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu Rev Pharmacol Toxicol 2008; 48: 537-568.
26. Tanowitz M, von Zastrow M: Ubiquitination- independent trafficking of G proteincoupled receptors to lysosomes. J Biol Chem 2002; 277: 50219-50222.
27. He J, Bellini M, Inuzuka H, et al: Proteomic analysis of- 1 -adrenergic receptor interactions with PDZ scaffold proteins. J Biol Chem 2006; 281: 2820-2827.
28. Hall RA, Premont RT, Chow CW, et al: The-2 -adrenergic receptor interacts with the Na + /H + exchanger regulatory factor to control Na + /H + exchange. Nature 1998; 392: 626-630.
29. Thompson D, Pusch M, Whistler JL: Changes in G protein-coupled receptor sorting protein affinity regulate postendocytic targeting of G protein-coupled receptors. J Biol Chem 2007; 282: 29178-29185.
30. Saksena S, Sun J, Chu T, Emr SD: ESCRTing proteins in the endocytic pathway. Trends Biochem Sci 2007; 32: 561-573.
31. Hurley JH, Emr SD: The ESCRT complexes: structure and mechanism of a membranetrafficking network. Annu Rev Biophys Biomol Struct 2006; 35: 277-298.
32. Slagsvold T, Pattni K, Malerød L, Stenmark H: Endosomal and non-endosomal functions of ESCRT proteins. Trends Cell Biol 2006; 16: 317-326.
33. Chin LS, Raynor MC, Wei X, Chen HQ, Li L: Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J Biol Chem 2001; 276: 7069-7078.
34. Wang Y, Zhou Y, Szabo K, Haft CR, Trejo J: Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1. Mol Biol Cell 2002; 13: 1965-1976.
35. Heydorn A, Søndergaard BP, Ersbøll B, et al: A library of 7TM receptor C-terminal tails: interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein
36. (EBP50), N-ethylmaleimidesensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). J Biol Chem 2004; 279: 54291-54303.
37. van Koppen CJ: Multiple pathways for the dynamin-regulated internalization of muscarinic acetylcholine receptors. Biochem Soc Trans 2001; 29(pt 4):505-508.
38. Krudewig R, Langer B, Vogler O, et al: Distinct internalization of M2 muscarinic acetylcholine receptors confers selective and long-lasting desensitization of signaling to phospholipase C. J Neurochem 2000; 74: 1721-1730.
39. Benson MA, Newey SE, Martin-Rendon E, Hawkes R, Blake DJ: Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. J Biol Chem 2001; 276: 24232-24241.
40. Marley A, von Zastrow M: Dysbindin promotes the post-endocytic sorting of G protein- coupled receptors to lysosomes. PLoS One 2010; 5:e9325.
41. Bartlett SE, Enquist J, Hopf FW, et al: Dopamine responsiveness is regulated by targeted sorting of D 2 receptors. Proc Natl Acad Sci USA 2005; 102: 11521-11526.
42. Boeuf J, Trigo JM, Moreau PH, et al: Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. Eur J Neurosci 2009; 30: 860-868.
43. Martini L, Waldhoer M, Pusch M, et al: Ligand- induced down-regulation of the cannabinoid 1 receptor is mediated by the Gprotein- coupled receptor-associated sorting protein GASP1. FASEB J 2007; 21: 802-811.
44. Tappe-Theodor A, Agarwal N, Katona I, et al: A molecular basis of analgesic tolerance to cannabinoids. J Neurosci 2007; 27: 4165-4177.
45. Tschische P, Moser E, Thompson D, et al: The G protein-coupled receptor-associated sorting protein GASP-1 regulates the signaling and trafficking of the viral chemokine receptor US28. Traffic 2010; 11: 660-674.
46. Thompson D, Martini L, Whistler JL: Altered ratio of D 1 and D 2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine. PLoS One, in press.
47. Enquist J, Skröder C, Whistler JL, Leeb- Lundberg LM: Kinins promote B 2 receptor endocytosis and delay constitutive B 1 receptor endocytosis. Mol Pharmacol 2007; 71: 494-507.
48. Simonin F, Karcher P, Boeuf JJ, Matifas A, Kieffer BL: Identification of a novel family of G protein-coupled receptor-associated sorting proteins. J Neurochem 2004; 89: 766-775.
49. Martini L, Thompson D, Kharazia V, Whistler JL: Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1. Neuropsychopharmacology 2010; 35: 1363-1373.
50. Suyama M, Nagase T, Ohara O: HUGE: a database for human large proteins identified by Kazusa cDNA sequencing project. Nucleic Acids Res 1999; 27: 338-339.
51. Horn SC, Lalowski M, Goehler H, Droge A, Wanker EE, Stelzl U: Huntingtin interacts with the receptor sorting family protein GASP2. J Neural Transm 2006; 113: 1081-1090.
52. Waldhoer M, Casarosa P, Rosenkilde MM, et al: The carboxyl terminus of human cytomegalovirus- encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biol Chem 2003; 278: 19473-19482.
53. Fraile-Ramos A, Kledal TN, Pelchen-Matthews A, Bowers K, Schwartz TW, Marsh M: The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling. Mol Biol Cell 2001; 12: 1737-1749.