Distinct internalization of M2 muscarinic acetylcholine receptors confers selective and long-lasting desensitization of signaling to phospholipase C

Journal of Neurochemistry

Volumn 74, Issue 4, 2000, Pages 1721-1730

  Krudewig, Riccarda ^a   Langer, Barbara ^a   Vögler, Oliver ^a   Markschies, Nicole ^a   Erl, Martin ^a   Jakobs, Karl H ^a   Van Koppen, Chris J ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Desensitization; HEK 293 cells; Muscarinic receptor; Phospholipase C; Receptor reserve; Sequestration

Indexed keywords

ADENYLATE CYCLASE; CALCIUM; MUSCARINIC M2 RECEPTOR; PHOSPHOLIPASE C; RECEPTOR RESERVE; CARBACHOL; CELL SURFACE RECEPTOR; CHOLINERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; DIAGNOSTIC AGENT; FORSKOLIN; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR; TRITIUM;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; CELL CULTURE; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; DOWN REGULATION; DRUG EFFECT; ENDOCYTOSIS; GENETIC TRANSFECTION; KIDNEY; KINETICS; METABOLISM; PHYSIOLOGY;

CALCIUM; CARBACHOL; CELL MEMBRANE; CELLS, CULTURED; CHOLINERGIC AGONISTS; CYCLIC AMP; DOWN-REGULATION; ENDOCYTOSIS; FORSKOLIN; HUMANS; KIDNEY; KINETICS; PHOSPHOLIPASE C; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M4; RECEPTORS, CELL SURFACE; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION; TRANSFECTION; TRITIUM;

EID: 0033622115     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0741721.x     Document Type: Article

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