Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Marley, Aaron ^a   Von Zastrow, Mark ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASM PROTEIN; DELTA OPIATE RECEPTOR; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DYSBINDIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPITOPE; G PROTEIN COUPLED RECEPTOR; GASP 1 PROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; CARRIER PROTEIN; DTNBP1 PROTEIN, HUMAN; ESCRT PROTEIN; GREEN FLUORESCENT PROTEIN; PROTEIN; WFIKKNRP PROTEIN, HUMAN;

ARTICLE; BIOCHEMISTRY; BIOGENESIS; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; ENDOCYTOSIS; HELA CELL; HUMAN; HUMAN CELL; IMMUNOCHEMISTRY; IMMUNOPRECIPITATION; LYSOSOME; NERVE CELL; PROTEIN DEPLETION; REGULATORY MECHANISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SURFACE PROPERTY; UPREGULATION; CELL LINE; FLUORESCENCE MICROSCOPY; GENETICS; IMMUNOBLOTTING; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TRANSPORT; TIME;

CARRIER PROTEINS; CELL LINE; ENDOCYTOSIS; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LYSOSOMES; MICROSCOPY, FLUORESCENCE; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, DOPAMINE D2; RECEPTORS, G-PROTEIN-COUPLED; RNA INTERFERENCE; TIME FACTORS;

EID: 77949529528     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009325     Document Type: Article

References (37)

1. Pierce KL, Lefkowitz RJ (2001) Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors. Nat Rev Neurosci 2: 727-733.
2. Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG (2004) Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 27: 107-144.
3. Sawa A, Snyder SH (2002) Schizophrenia: diverse approaches to a complex disease. Science 296: 692-695.
4. Ryder PV, Faundez V (2009) Schizophrenia: the "BLOC" may be in the endosomes. Sci Signal 2: pe66.
5. Benson MA, Newey SE, Martin-Rendon E, Hawkes R, Blake DJ (2001) Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. J Biol Chem 276: 24232-24241.
6. Falcon-Perez JM, Starcevic M, Gautam R, Dell'Angelica EC (2002) BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules. J Biol Chem 277: 28191-28199.
7. Morello JP, Petaja-Repo UE, Bichet DG, Bouvier M (2000) Pharmacological chaperones: a new twist on receptor folding. Trends Pharmacol Sci 21: 466-469.
8. Wei LN, Loh HH (2002) Regulation of opioid receptor expression. Curr Opin Pharmacol 2: 69-75.
9. Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, et al. (2002) Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet 71: 337-348.
10. Scheiffele P, Fan J, Choih J, Fetter R, Serafini T (2000) Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101: 657-669.
11. van den Oord EJ, Sullivan PF, Jiang Y, Walsh D, O'Neill FA, et al. (2003) Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families. Mol Psychiatry 8: 499-510.
12. Kumamoto N, Matsuzaki S, Inoue K, Hattori T, Shimizu S, et al. (2006) Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin. Biochem Biophys Res Commun 345: 904-909.
13. Iizuka Y, Sei Y, Weinberger DR, Straub RE (2007) Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization. J Neurosci 27: 12390-12395.
14. Schmid SL, Smythe E (1991) Stage-specific assays for coated pit formation and coated vesicle budding in vitro. J Cell Biol 114: 869-880.
15. Ehlers MD (2000) Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron 28: 511-525.
16. Law PY, Wong YH, Loh HH (2000) Molecular mechanisms and regulation of opioid receptor signaling. Annu Rev Pharmacol Toxicol 40: 389-430.
17. Tsao PI, von Zastrow M (2000) Type-specific sorting of G protein-coupled receptors after endocytosis. J Biol Chem 275: 11130-11140.
18. Pradhan AA, Becker JA, Scherrer G, Tryoen-Toth P, Filliol D, et al. (2009) In vivo delta opioid receptor internalization controls behavioral effects of agonists. PLoS One 4: e5425.
19. Huang F, Kirkpatrick D, Jiang X, Gygi S, Sorkin A (2006) Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell 21: 737-748.
20. Hislop JN, Marley A, Von Zastrow M (2004) Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes. J Biol Chem 279: 22522-22531.
21. Nazarian R, Starcevic M, Spencer MJ, Dell'Angelica EC (2006) Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein. Biochem J 395: 587-598.
22. Whistler JL, Enquist J, Marley A, Fong J, Gladher F, et al. (2002) Modulation of postendocytic sorting of G protein-coupled receptors. Science 297: 615-620.
23. Raiborg C, Stenmark H (2002) Hrs and endocytic sorting of ubiquitinated membrane proteins. Cell Struct Funct 27: 403-408.
24. Raiborg C, Rusten TE, Stenmark H (2003) Protein sorting into multivesicular endosomes. Curr Opin Cell Biol 15: 446-455.
25. Formstecher E, Aresta S, Collura V, Hamburger A, Meil A, et al. (2005) Protein interaction mapping: a Drosophila case study. Genome Res 15: 376-384.
26. Di Pietro SM, Falcon-Perez JM, Tenza D, Setty SR, Marks MS, et al. (2006) BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Mol Biol Cell 17: 4027-4038.
27. Bartlett SE, Enquist J, Hopf FW, Lee JH, Gladher F, et al. (2005) Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proc Natl Acad Sci U S A 102: 11521-11526.
28. Ji Y, Yang F, Papaleo F, Wang HX, Gao WJ, et al. (2009) Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc Natl Acad Sci U S A 106: 19593-19598.
29. Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, et al. (2007) Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry 12: 74-86.
30. Bhardwaj SK, Baharnoori M, Sharif-Askari B, Kamath A, Williams S, et al. (2009) Behavioral characterization of dysbindin-1 deficient sandy mice. Behav Brain Res 197: 435-441.
31. Cox MM, Tucker AM, Tang J, Talbot K, Richer DC, et al. (2009) Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background. Genes Brain Behav 8: 390-397.
32. Jentsch JD, Trantham-Davidson H, Jairl C, Tinsley M, Cannon TD, et al. (2009) Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology 34: 2601-2608.
33. Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (2001) Hrs recruits clathrin to early endosomes. Embo J 20: 5008-5021.
34. Chu P, Murray S, Lissin D, von Zastrow M (1997) Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist. J Biol Chem 272: 27124-27130.
35. Vickery RG, von Zastrow M (1999) Distinct dynamin-dependent and - independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes. J Cell Biol 144: 31-43.
36. Starcevic M, Dell'Angelica EC (2004) Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem 279: 28393-28401.
37. Hislop JN, Henry AG, Marchese A, von Zastrow M (2009) Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes. J Biol Chem 284: 19361-19370.