Progression to diabetes in relatives with islet autoantibdies: Is it inevitable?

Diabetes Care

Volumn 22, Issue 12, 1999, Pages 2049-2054

  Gardner, Stephen G ^a   Gale, Edwin A M ^a   Williams, Alistair J K ^a   Gillespie, Kathleen M ^d   Lawrence, Katherine E ^a   Bottazzo, Gian Franco ^b   Bingley, Polly J ^a,c  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^c SOUTHMEAD HOSPITAL   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR ANTIBODY;

ADULT; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNE DISEASE; GENETIC SUSCEPTIBILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PANCREAS ISLET; RISK ASSESSMENT;

EID: 0033361051     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.22.12.2049     Document Type: Article

References (24)

1. Bonifacio E, Bingley PJ, Dean BM, Shattock M, Dunger D, Gale EAM, Bottazzo GF: Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 335:147-149, 1990
2. Riley WJ, Maclaren NK, Krischer J, Spillar RP, Silverstein J, Schatz DA, Schwartz S, Malone J, Shah S, Vadheim C, Rotter JI: A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med 323: 1167-1172, 1990
3. Lipton RB, Atchison JJ, Dorman JS, Duquesnoy RJ, Eckenrode K, Orchard TJ, LaPorte RE, Riley WJ, Kuller LH, Drash AL, Becker DJ: Genetic, immunological, and metabolic determinants of risk for type 1 diabetes mellitus in families. Diabet Med 9:224-232, 1992
4. Bingley PJ, the ICARUS Group: Interactions of age, islet cell antibodies, insulin autoantibodies, and first-phase insulin response in predicting risk of progression to IDDM in ICA positive relatives. Diabetes 45:1720-1728, 1996
5. Bingley PJ, Christie MR, Bonifacio E, Bonfanti R, Shattock M, Fonte MT, Bottazzo GF, Gale EAM: Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 43:1304-1310, 1994
6. Christie MR, Roll U, Payton MA, Hatfield ECI, Ziegler AG: Validity of screening for individuals at risk for type 1 diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care 20:965-970, 1997
7. Deschamps I, Boitard C, Hors J, Busson M, Marcelli-Barge A, Mogenet A, Robert J: Life table analysis of the risk of type 1 (insulin-dependent) diabetes in siblings according to islet cell antibodies and HLA markers. Diabetologia 35:951-957, 1992
8. Christie MR, Genovese S, Cassidy D, Bosi E, Brown TJ, Lai M, Bonifacio E, Bottazzo GF: Antibodies to islet 37k antigen but not to glutamate decarboxylase discriminate rapid progression to insulin-dependent diabetes mellitus in endocrine autoimmunity. Diabetologia 43:1254-1259, 1994
9. Bingley PJ, Gale EAM: The incidence of insulin-dependent diabetes in England: a study in the Oxford region 1985-6, BMJ 298:558-560, 1989
10. Bingley PJ, Bonifacio E, Williams AJK, Genovese S, Bottazzo GF, Gale EAM: Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. Diabetes 46:1701-1710, 1997
11. Verge CF, Stenger D, Bonifacio E, Colman PG, Pilcher C, Bingley PJ, Eisenbarth GS, participating laboratories: Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: combinatorial islet autoantibody workshop. Diabetes 47:1857-1866, 1998
12. Williams AJK, Bingley PJ, Bonifacio E, Palmer JP, Gale EAM: A novel micro-assay for insulin autoantibodies. J Autoimmun 10:473-478, 1997
13. Bingley PJ, Bonifacio E, Shattock M, Gillmor HA, Sawtell PA, Dunger DB, Scott RDM, Bottazzo GF, Gale EAM: Can islet cell antibodies predict IDDM in the general population? Diabetes Care 16:45-50, 1993
14. Miller S, Dykes D, Polesky H: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215, 1988
15. Bunce M, Taylor CJ, Welsh KI: Rapid HLA-DQB1 typing by eight polymerase chain reaction amplifications with sequence specific primers. Hum Immunol 37:201-206, 1993
16. Mullighan CG, Bunce M, Welsh KI: High resolution HLA-DQB1 typing using the polymerase chain reaction and sequence-specific primers. Tissue Antigens 50:688-692, 1997
17. Tarn AC, Thomas JM, Dean BM, Ingram D, Schwarz G, Bottazzo GF, Gale EAM: Predicting insulin-dependent diabetes. Lancet i:845-860, 1988
18. Bland JM: An introduction to medical statistics. Oxford, Oxford University Press, 1995
19. World Health Organization: Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Org., 1985 (Tech. Rep. Ser., no. 727)
20. McCulloch DK, Klaff LJ, Kahn SE, Schoenfield SL, Greenbaum CJ, Mauseth RS, Benson EA, Nepom GT, Shewey L, Palmer JP: Nonprogression of subclinical β-cell dysfunction among first-degree relatives of IDDM patients: 5-yr follow-up of the Seattle Family Study Diabetes 39:549-556, 1990
21. Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS: Prediction of type 1 diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-933, 1996
22. Yu L, Gianani R, Eisenbarth GS: Quantitation of glutamic acid decarboxylase autoantibody levels in prospectively evaluated relatives of patients with type 1 diabetes, Diabetes 43:1229-1233, 1994
23. Greenbaum CJ, Sears KL, Kahn SE, Palmer JP: Relationship of β-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: follow-up of the Seattle Family Study Diabetes 48:170-175, 1999
24. Bonifacio E, Genovese S, Braghi S, Bazzigaluppi E, Lampasona V, Bingley PJ, Rogge L, Pastore MR, Bognetti E, Bottazzo GF, Gale EAM: Islet autoantibody markers in IDDM: identification of screening strategies for risk assessment yielding high sensitivity. Diabetologia 38:816-822, 1995