TH1/TH2 cytokine secretion of first degree relatives of T1DM patients

Cytokine

Volumn 30, Issue 5, 2005, Pages 219-227

  Rapoport, Micha J ^a   Bistritzer, Tzvi ^a   Aharoni, Dorit ^a   Weiss, Mordechai ^a   Ramot, Yoram ^a   Buchs, Andreas ^a   Bloch, Konstantin ^b   Vardi, Pnina ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b CLALIT HEALTH SERVICES   (Israel)

Author keywords

Cytokines; Human; Lymphocytes; Th1; Th2; Type I diabetes

Indexed keywords

AUTOANTIBODY; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ARTICLE; CASE REPORT; CHILD; CYTOKINE RELEASE; DATA ANALYSIS; DISEASE COURSE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; CYTOKINES; DIABETES MELLITUS, TYPE 1; FAMILY; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; MALE; PEDIGREE; TH1 CELLS; TH2 CELLS; TIME FACTORS;

EID: 20144364246     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2005.01.012     Document Type: Article

References (25)

1. L. Castano, and G.S. Eisenbarth Type-I diabetes: a chronic autoimmune disease of human, mouse and rat Ann Rev Immunol 8 1990 647 679
2. A. Rabinovitch Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes 43 1994 613 621
3. W.Y. Almwai, H. Tamim, and S.T. Azar Clinical review 103: T helper type 1 and 2 cytokines mediate the onset and progression of type I (insulin-dependent) diabetes J Clin Endocrinol Metab 84 1999 1497 1502
4. A. Rabinovitch, and W.L. Suarez-Pinzon Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus Biochem Pharmacol 55 1998 1139 1149
5. M.A. Berman, C.I. Sandborg, Z. Wang, K.L. Imfeld, F. Zaldivar Jr., and V. Dadufalza Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus J Immunol 157 1996 4690 4696
6. P. Achenbach, K. Warncke, J. Reiter, H.E. Naserke, A.J. Williams, and P.J. Bingley Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics Diabetes 53 2004 384 392
7. B.A. Kallmann, E.F. Lampetr, P. Hanifi-Moghaddam, M. Hawa, R.D.G. Leslie, and H. Kolb Cytokine secretion patterns in twins discordant for Type I diabetes Diabetologia 42 1999 1080 1085
8. M.G. Karlsson, S.S. Lawesson, and J. Ludvigsson Th1-like dominance in high risk first-degree relatives of type I diabetic patients Diabetologia 43 2000 742 749
9. A. Szelachowska, A. Kretowski, and I. Kinalska Decreased in vitro IL-10 production by peripheral blood in first degree relatives at high risk of diabetes Type-I Horm Metab Res 30 1998 526 530
10. S.B. Wilson, S.C. Kent, K.T. Patton, T. Orban, R.A. Jackson, and M. Exley Extreme Th1 bias of invariant Va24JaQT T cells in type 1 diabetes Nature 391 1998 177 181
11. M.J. Rapoport, A. Mor, P. Vardi, Y. Ramot, R. Winker, and A. Hindi Decreased secretion of Th2 cytokines precedes upregulated and delayed secretion of Th1 cytokines in activated peripheral blood mononuclear cells from patients with insulin dependent diabetes mellitus J Autoimmunity 11 1998 635 642
12. B.A. Kallman, M. Huther, M. Tubes, J. Feldkamp, J. Bertrams, and F.A. Gries Systemic bias of cytokine production toward cell mediated immune regulation in IDDM and toward humoral immunity in Graves' disease Diabetes 46 1997 237 243
13. S. Mrena, K. Savola, P. Kulmala, H.K. Akerblom, and M. Knip Staging of preclinical Type 1 Diabetes in siblings of affected children Pediatrics 104 1999 925 930
14. M. Falcone, B. Yeung, L. Tucker, E. Rodriguez, T. Krahl, and N. Sarvetnick IL-4 triggers autoimmune diabetes by increasing self-antigen presentation within the pancreatic islets Clin Immunol 98 2001 190 199
15. M.J. Rapoport, A. Jaramillo, D. Zipris, A.H. Lazarus, D.V. Serreze, and E.H. Leiter Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice J Exp Med 178 1993 87 99
16. A. Shimada, B. Charlton, C. Taylor-Edwards, and C.G. Fathman Beta-cell destruction may be a late consequence of the autoimmune process in nonobese diabetic mice Diabetes 45 1996 1063 1067
17. P. Hanifi-Moghaddam, N.C. Schloot, S. Kappler, J. Seibler, and H. Kolb An association of autoantibody status and serum cytokine levels in Type 1 Diabetes Diabetes 52 2003 1137 1142
18. D.A. Schatz, and P.J. Bingley Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT) J Pediatr Endocrinol Metab 14 Suppl. 1 2001 619 622
19. Diabetes Prevention Trial - Type 1 Diabetes Study Group Effects of insulin in relatives of patients with Type 1 Diabetes Mellitus N Engl J Med 346 2002 1685 1691
20. P.J. Bingley, E. Bonifacio, A.G. Ziegler, D.A. Schatz, M.A. Atkinson, and G.S. Eisenbarth Immunology of Diabetes Society. Proposed guidelines on screening for risk of type 1 diabetes Diabetes Care 24 2001 398
21. O.J. Kwon, C. Brautbar, N. Weintrob, E. Sprecher, C. Saphirman, and K. Bloch Immunogenetics of HLA class II in Israeli Ashkenazi Jewish, Israeli non-Ashkenazi Jewish, and in Israeli Arab IDDM patients Hum Immunol 62 2001 85 91
22. The expert committee on the diagnosis and classification of diabetes mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997;20:1183-97.
23. C.E. Grubin, T. Daniels, B. Toivola, M. Landin-Olson, W.A. Hagopian, and L. Li A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM Diabetologia 37 1994 304 350
24. R. Gianani, D.U. Rabin, C.F. Verge, L. Yu, R. Babu, and M. Pietropaolo ICA512 Autoantibody radioassay Diabetes 44 1995 1340 1344
25. W.J. Dixon BMDP Statistical Software 1990 University of California Press