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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5232-5236

Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents

(8) Kamal, Ahmed a Reddy, J Surendranadha a Ramaiah, M Janaki a Bharathi, E Vijaya a Dastagiri, D a Reddy, M Kashi a Pushpavalli, S N C V L a Pal Bhadra, Manika a

a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY (India)

Author keywords

Apoptosis; Cytochrome c; Cytotoxicity; DNA binding affinity; p53; Poly ADP ribose polymerase (PARP); Pyrrolobenzodiazepine

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; CYTOCHROME C; DOXORUBICIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; PYRROLOBENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CONJUGATION; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; SUBSTITUTION REACTION;

ANILINE COMPOUNDS; BENZODIAZEPINES; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PYRIMIDINES;

EID: 77955656508 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.06.147 Document Type: Article

Times cited : (14)

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