Discovery of substituted 4-anilino-2-arylpyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 2. Structure-activity relationships of the 2-aryl group

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2305-2309

  Sirisoma, Nilantha ^a   Pervin, Azra ^a   Nguyen, Bao ^a   Crogan Grundy, Candace ^a   Kasibhatla, Shailaja ^a   Tseng, Ben ^a   Drewe, John ^a   Cai, Sui Xiong ^a  

^a EpiCept Corporation   (United States)

Author keywords

Anticancer agents; Apoptosis inducers; HTS; SAR

Indexed keywords

2,5 DIMETHOXY DERIVATIVE; 3,5 DICHLORO 4 PYRIDYL DERIVATIVE; 4 ANILINO 2 (2 PYRIDYL)PYRIMIDINE DERIVATIVE; 4 ANILINO 2 ARYLPYRIMIDINE DERIVATIVE; APOPTOSIS INDUCING FACTOR; BENZENE DERIVATIVE; CASPASE; PYRIMIDINE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; DRUG POTENCY; DRUG SUBSTITUTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 63149091205     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.074     Document Type: Article

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