Genome-wide changes accompanying the knockdown of Ep-CAM in retinoblastoma

Molecular Vision

Volumn 16, Issue , 2010, Pages 828-842

  Mitra, Moutushy ^a,c   Kandalam, Mallikarjuna ^a   Verma, Rama Shanker ^b   Uma Maheswari, Krishnan ^c   Krishnakumar, Subramanian ^a  

^a VISION RESEARCH FOUNDATION   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

^c SASTRA UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; EPITHELIAL CELL ADHESION MOLECULE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; SMALL INTERFERING RNA;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA MICROARRAY; DNA REPLICATION; DNA TRANSCRIPTION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE SILENCING; GENOME ANALYSIS; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETINOBLASTOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UNINDEXED SEQUENCE; UPREGULATION; WESTERN BLOTTING;

ANTIGENS, NEOPLASM; AZACITIDINE; CELL ADHESION MOLECULES; CELL LINE; CELL PROLIFERATION; DOWN-REGULATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENOME, HUMAN; HUMANS; MICROARRAY ANALYSIS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; RETINOBLASTOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 77955647552     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Suzuki S, Kaneko A. Management of intraocular retinoblastoma and ocular prognosis. Int J Clin Oncol 2004; 9:1-6.
2. Kremens B, Wieland R, Reinhard H, Neubert D, Beck JD, Klingebiel T, Bornfeld N, Havers W. High-dose chemotherapy with autologous stem cell rescue in children with retinoblastoma. Bone Marrow Transplant 2003; 31:281-4.
3. Grabowski EF, Abramson DH. Intraocular and extraocular retinoblastoma. Hematol Oncol Clin North Am 1987; 1:721-35.
4. Doz F, Khelfaoui F, Mosseri V, Validire P, Quintana E, Michon J, Desjardins L, Schlienger P, Neuenschwander S, Vielh P, Putterman M, Dufier J-L. Jean-Michael Zucker The role of chemotherapy in orbital involvement of retinoblastoma. The experience of a single institution with 33 patients. Cancer 1994; 74:722-32.
5. Schvartzman E, Chantada G, Fandiño A, de Dávila MT, Raslawski E, Manzitti J. Results of a stage-based-protocol for the treatment of retinoblastoma. J Clin Oncol 1996; 14:1532-6.
6. Krishnakumar S, Mohan A, Mallikarjuna K, Venkatesan N, Biswas J, Shanmugam MP, Ren-Heidenreich L. Ep-CAM expression in retinoblastoma: a novel molecular target for therapy. Invest Ophthalmol Vis Sci 2004; 45:4247-50.
7. Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, Cole DJ, Gillanders WE. Ep-CAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 2004; 64:5818-24.
8. Winter MJ, Nagtegaal ID, van Krieken JH, Litvinov SV. The epithelial cell adhesion molecule (Ep-CAM) as a morphoregulatory molecule is a tool in surgical pathology. Am J Pathol 2003; 163:2139-48.
9. Koprowski H, Steplewski Z, Mitchell K, Herlyn M, Herlyn D, Fuhrer P. Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet 1979; 5:957-72.
10. Zorzos J, Zizi A, Bakiras A, Pectasidis D, Skarlos DV, Zorzos H, Elemenoglou J, Likourinas M. Expression of a cell surface antigen recognized by the monoclonal antibody AUA1 in bladder carcinoma: an immunohistochemical study. Eur Urol 1995; 28:251-4.
11. Braun S, Hepp F, Kentenich CR, Janni W, Pantel K, Riethmüller G, Willgeroth F, Sommer HL. Monoclonal antibody therapy with edrecolomab in breast cancer patients: monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow. Clin Cancer Res 1999; 5:3999-4004.
12. Seligson DB, Pantuck AJ, Liu X, Huang Y, Horvath S, Bui MH, Han KR, Correa AJ, Eeva M, Tze S, Belldegrun AS, Figlin RA. Epithelial cell adhesion molecule (KSA) expression: pathobiology and its role as an independent predictor of survival in renal cell carcinoma. Clin Cancer Res 2004; 10:2659-69.
13. de Boer CJ, van Krieken JH, Janssen-van Rhijn CM, Litvinov SV. Expression of Ep-CAM in normal, regenerating, metaplastic, and neoplastic liver. J Pathol 1999; 188:201-6.
14. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411:494-8.
15. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25:402-8.
16. van der Gun BT, Wasserkort R, Monami A, Jeltsch A, Raskó T, Slaska-Kiss K, Cortese R, Rots MG, de Leij LF, Ruiters MH, Kiss A, Weinhold E, McLaughlin PM. Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation. Int J Cancer 2008; 123:484-9.
17. Shiah SG, Chang LC, Tai KY, Lee GH, Wu CW, Shieh YS. The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of Ep-CAM expression in oral squamous cell carcinoma. Oral Oncol 2009; 45:e1-8.
18. Spizzo G, Gastl G, Obrist P, Fong D, Haun M, Grünewald K, Parson W, Eichmann C, Millinger S, Fiegl H, Margreiter R, Amberger A. Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue. Cancer Lett 2007; 246:253-61.
19. Tai KY, Shiah SG, Shieh YS, Kao YR, Chi CY, Huang E, Lee HS, Chang LC, Yang PC, Wu CW. DNA methylation and histone modification regulate silencing of epithelial cell adhesion molecule for tumor invasion and progression. Oncogene 2007; 26:3989-97.
20. Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002; 30:207-10.
21. Chévez-Barrios P, Hurwitz MY, Louie K, Marcus KT, Holcombe VN, Schafer P, Aguilar-Cordova CE, Hurwitz RL. Metastatic and nonmetastatic models of retinoblastoma. Am J Pathol 2000; 157:1405-12.
22. Biswas J, Das D, Krishnakumar S, Shanmugam MP. Histopathologic analysis of 232 eyes with retinoblastoma conducted in an Indian tertiary-care ophthalmic center. J Pediatr Ophthalmol Strabismus 2003; 40:265-7.
23. Riggs AD. X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet 1975; 14:9-25.
24. Singal R, Ginder GD. DNA methylation. Blood 1999; 93:4059-70.
25. Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128:683-92.
26. Münz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O. The carcinoma-associated antigen Ep-CAM upregulates c-myc and induces cell proliferation. Oncogene 2004; 23:5748-58.
27. Maetzel D, Denzel S, Mack B, Canis M, Went P, Benk M, Kieu C, Papior P, Baeuerle PA, Munz M, Gires O. Nuclear signalling by tumour-associated antigen Ep-CAM. Nat Cell Biol 2009; 11:162-71.
28. Dimaras H, Khetan V, Halliday W, Orlic M, Prigoda NL, Piovesan B, Marrano P, Corson TW, Eagle RC Jr, Squire JA, Gallie BL. Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma. Hum Mol Genet 2008; 17:1363-72.
29. Wenqi D, Li W, Shanshan C, Bei C, Yafei Z, Feihu B, Jie L, Daiming F. EpCAM is overexpressed in gastric cancer and its downregulation suppresses proliferation of gastric cancer. J Cancer Res Clin Oncol 2009; 135:1277-85.
30. Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126:121-34.
31. Goldstein JC, Muñoz-Pinedo C, Ricci JE, Adams SR, Kelekar A, Schuler M, Tsien RY, Green DR. Cytochrome c is released in a single step during apoptosis. Cell Death Differ 2005; 12:453-62.
32. Baeuerle PA, Gires O. Ep-CAM (CD326) Finding its role in cancer. Br J Cancer 2007; 96:417-23.
33. Orlic M, Spencer CE, Wang L, Gallie BL. Expression analysis of 6p22 genomic gain in retinoblastoma. Genes Chromosomes Cancer 2006; 45:72-82.
34. Gladden AB, Diehl JA. Location, location, location: the role of cyclin D1 nuclear localization in cancer. J Cell Biochem 2005; 96:906-13.
35. Yaari S, Jacob-Hirsch J, Amariglio N, Haklai R, Rechavi G, Kloog Y. Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest. Clin Cancer Res 2005; 11:4321-30.
36. MacPherson D, Conkrite K, Tam M, Mukai S, Mu D, Jacks T. Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J 2007; 26:784-94.
37. Sakai K, Tanooka H, Sasaki MS, Ejima Y, Kaneko A. Increase in copy number of N-myc in retinoblastomas in comparison with chromosome abnormality. Cancer Genet Cytogenet 1988; 30:119-26.
38. Adithi M, Nalini V, Kandalam M, Krishnakumar S. Expression of matrix metalloproteinases and their inhibitors in retinoblastoma. J Pediatr Hematol Oncol 2007; 29:399-405.
39. Adithi M, Venkatesan N, Kandalam M, Biswas J, Krishnakumar S. Expressions of Rac1, Tiam1 and Cdc42 in retinoblastoma. Exp Eye Res 2006; 83:1446-52.
40. Balzar M, Winter MJ, de Boer CJ, Litvinov SV. The biology of the 17-1A antigen (Ep-CAM). J Mol Med 1999; 77:699-712.
41. Pauli C, Münz M, Kieu C, Mack B, Breinl P, Wollenberg B, Lang S, Zeidler R, Gires O. Tumor-specific glycosylation of the carcinoma associated epithelial cell adhesion molecule Ep-CAM in head and neck carcinomas. Cancer Lett 2003; 193:25-32.