Expression of Ep-CAM in normal, regenerating, metaplastic, and neoplastic liver

Journal of Pathology

Volumn 188, Issue 2, 1999, Pages 201-206

  De Boer, Carla J ^a   Van Krieken, Johan H J M ^a   Rhijn, Connie M Janssen Van ^a   Litvinov, Sergey V ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cholangiocarcinoma; Differentiation; Ep CAM; Hepatocellular carcinoma; Immunohistochemistry; Proliferati on

Indexed keywords

CELL ADHESION MOLECULE;

ARTICLE; BILE DUCT CARCINOMA; CELL DIFFERENTIATION; CELL PROLIFERATION; DIAGNOSTIC VALUE; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PRIORITY JOURNAL;

ADULT; ANTIGENS, NEOPLASM; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CARCINOMA, HEPATOCELLULAR; CELL ADHESION MOLECULES; CHOLANGIOCARCINOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS; LIVER REGENERATION; METAPLASIA; TUMOR MARKERS, BIOLOGICAL;

EID: 0032982570     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199906)188:2<201::AID-PATH339>3.0.CO;2-8     Document Type: Article

References (44)

1. Fausto N. Hepatocyte differentiation and liver progenitor cells. Curr Opin Cell Biol 1990; 2: 1036-1042.
2. Marceau N, Blouin MJ, Germain L, Noel M. Role of different epithelial cell types in liver ontogenesis, regeneration and neoplasia. In Vitro Cell Dev Biol 1989; 25: 336-341.
3. Sell S. Is there a liver stem cell? Cancer Res 1990; 50: 3811-3815.
4. Ponder KP. Analysis of liver development, regeneration, and carcinogenesis by genetic marking studies. FASEB J 1996; 10: 673-684.
5. Ihara A, Koizumi H, Hashizume R, Uchikoshi T. Expression of epithelial cadherin and α- and β-catenins in nontumoral livers and hepatocellular carcinomas. Hepatology 1996; 23: 1441-1447.
6. Kozyraki R, Scoazec JY, Flejou JF, et al. Expression of cadherins and alpha-catenin in primary epithelial tumors of the liver. Gastroenterology 1996; 110: 1137-1149.
7. Scoazec JY. Adhesion molecules in normal human liver. HepatoGastroenterology 1996; 43: 1103-1105.
8. Knittel T, Aurisch S, Neubauer K, Eichhorst S, Ramadori G. Cell type specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Am J Pathol 1996; 149: 449-462.
9. Thompson JA. Molecular cloning and expression of carcinoembryonic antigen gene family. Tumour Biol 1995; 16: 10-16.
10. Koelma IA, Nap M, Huitema S, Krom RAF, Houthoff HJ. Hepatocellular carcinoma, adenoma, and focal nodular hyperplasia. Arch Pathol Lab Med 1986; 110: 1035-1040.
11. Tanaka K, Hinoda Y, Takahashi H, Sakamoto H, Nakajima Y, Imai K. Decreased expression of biliary glycoprotein in hepatocellular carcinomas. Int J Cancer 1997; 74: 15-19.
12. Hinoda Y, Imai K, Nakagawa N, et al. Transcription of biliary glycoprotein I gene in malignant and non-malignant human liver tissue, Int J Cancer 1990; 45: 875-878.
13. Barnett TR, Kretschmer A, Austen DA, et al. Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the Carcinoembryonic antigen family. J Cell Biol 1989; 108: 267-276.
14. Shimoyama Y, Hirohashi S. Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma. Cancer Lett 1991; 57: 131-135.
15. Kanai Y, Ushijima S, Hui AM, et al. The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas, Int J Cancer 1997; 71: 355-359.
16. Litvinov SV, Bakker HAM, Gourevitch MM, Velders MP, Warnaar SO. Evidence for a role of the epithelial glycoprotein 40 (Ep-CAM) in epithelial cell-cell adhesion. Cell Adhes Commun 1994; 2: 417-428.
17. Litvinov SV, Velders MP, Bakker HAM, Fleuren GJ, Warnaar SO. Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol 1994; 125: 437-446.
18. Litvinov SV. Ep-CAM: a homophilic cell-cell adhesion molecule with EGF-like domains. Tr Glycosc Glycotechn 1995; 7: 375-384.
19. Tsubura A, Senzaki H, Sasaki M, Hilgers J, Morii S. Immunohistochemical demonstration of breast-derived and/or carcinoma-associated glycoproteins in normal skin appendages and their tumors. J Cutan Pathol 1992; 19: 73-79.
20. Quak JJ, Van Dongen G, Brakkee JG, et al. Production of a monoclonal antibody (K931) to a squamous cell carcinoma associated antigen identified as the 17-1A antigen. Hybridoma 1990; 9: 377-387.
21. Litvinov SV, Van Driel W, Van Rhijn CM, et al. Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation. Am J Pathol 1996; 148: 865-875.
22. High AS, Robinson PA, Klein CE. Increased expression of a 38 kD cell-surface glycoprotein MH99 (KS1/4) in oral mucosal dysplasia. J Oral Pathol Med 1996; 25: 10-13.
23. Litvinov SV, Balzar M, Winter MJ, et al. Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins. J Cell Biol 1997; 139: 1337-1348.
24. Van Muijen GNP, Warnaar SO, Ponec M. Differentiation-related changes of cytokeratin expression in cultured keratinocytes and in fetal, newborn, and adult epidermis. Exp Cell Res 1987; 171: 331-345.
25. r 43000 membrane glycoprotein associated with human breast cancer. Cancer Res 1986; 46: 1306-1317.
26. De Leeuw WJF, Berx G, Vos CBJ, et al. Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ. J Pathol 1997; 183: 404-411.
27. Desmet V, Roskams T, Van Eyken P. Ductular reaction in the liver. Pathol Res Pract 1995; 191: 513-524.
28. Cirulli V, Crisa L, Beattie GM, et al. KSA antigen Ep-CAM mediates cell-cell adhesion of pancreatic epithelial cells: morphoregulatory roles in pancreatic islet development. J Cell Biol 1998: 140: 1519-1534.
29. Frixen UH, Behrens J, Sachs M, et al. E-cadherin mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991; 113: 173-185.
30. Takahashi K, Suzuki K. Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion. Exp Cell Res 1996; 226: 214-222.
31. Tsukatani Y, Suzuki K, Takahashi K. Loss of density dependent growth inhibition and dissociation of alpha-catenin from E-cadherin. J Cell Physiol 1997; 173: 54-63.
32. Hermiston ML, Gordon JI. In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J Cell Biol 1995; 129: 489-506.
33. Hermiston ML, Wong MH, Gordon JI. Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system. Genes Dev 1996; 10: 985-996.
34. Wilding J, Vousden KH, Soutter WP, McCrea PD, Del Buono R, Pignatelli M. E-cadherin transfection down-regulates the epidermal growth factor receptor and reverses the invasive phenotype of human papilloma virus-transfected keratinocytes. Cancer Res 1996; 56: 5285-5292.
35. Zhu AJ, Watt FM. Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes. J Cell Sci 1996; 109: 3013-3023.
36. Wheelock MJ, Jensen PJ. Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherin. J Cell Biol 1992; 117: 415-425.
37. Lewis JE, Jensen PJ, Wheelock MJ. Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium. J Invest Dermatol 1994; 102: 870-877.
38. Bracke ME, Depypere H, Labit C, et al. Functional downregulation of the E-cadherin/catenin complex leads to loss of contact inhibition of motility and of mitochondrial activity, but not of growth in confluent epithelial cell cultures. Ear J Cell Biol 1997; 74: 342-349.
39. Van Dijk J, Tsuruo T, Segal DM, et al. Bispecific antibodies reactive with the multidrug-resistance-related glycoprotein and CD3 induce lysis of multidrug-resistant tumour cells. Int J Cancer 1989; 44: 738-743.
40. Wu PC, Fang JWS, Lau VKT, Lai CL, Lo CK, Lau JYN. Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Am J Pathol 1996; 149: 1167-1175.
41. Scoazec JY, Flejou JF, D'Errico A, et al. Fibrolamellar carcinoma of the liver: composition of the extracellular matrix and expression of cell-matrix and cell-cell adhesion molecules. Hepatology 1996; 24: 1128-1136.
42. Goodman ZD, Usa MMC, Ishak KG, Langloss JM, Sesterhenn IA, Rabin L. Combined hepatocellular-cholangiocarcinoma. A histological and immunohistochemical study. Cancer 1985; 55: 124-135.
43. Sigal SH, Bril S, Fiorino AS, Reid LM. The liver as a stem cell and lineage system. Am J Physiol 1992; 26: G139-G148.
44. Roskams T, De Vos R, Desmet V. 'Undifferentiated progenitor cells' in focal nodular hyperplasia of the liver. Histopathology 1996; 28: 291-299.