메뉴 건너뛰기




Volumn 88, Issue 8, 2010, Pages 679-688

Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women

Author keywords

Folate; Genetics; Homocysteine; Reproductive age; Spina bifida risk; Women

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID DERIVATIVE; HOMOCYSTEINE; METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE; METHIONINE SYNTHASE; REDUCED FOLATE CARRIER; TETRAHYDROFOLIC ACID; THYMIDYLATE SYNTHASE;

EID: 77955620303     PISSN: 15420752     EISSN: 15420760     Source Type: Journal    
DOI: 10.1002/bdra.20683     Document Type: Article
Times cited : (16)

References (62)
  • 1
    • 0032573077 scopus 로고    scopus 로고
    • A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells
    • Bagley PJ, Selhub J. 1998. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 95:13217-13220.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13217-13220
    • Bagley, P.J.1    Selhub, J.2
  • 2
    • 0033547440 scopus 로고    scopus 로고
    • Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention
    • Berry RJ, Li Z, Erickson JD, et al. 1999. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 341:1485-1490.
    • (1999) N Engl J Med , vol.341 , pp. 1485-1490
    • Berry, R.J.1    Li, Z.2    Erickson, J.D.3
  • 3
    • 0034190659 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE review
    • Botto LD, Yang Q. 2000. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151:862-877.
    • (2000) Am J Epidemiol , vol.151 , pp. 862-877
    • Botto, L.D.1    Yang, Q.2
  • 4
    • 18644379774 scopus 로고    scopus 로고
    • A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: Report of the Birth Defects Research Group
    • Brody LC, Conley M, Cox C, et al. 2002. A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/ methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. Am J Hum Genet 71:1207-1215.
    • (2002) Am J Hum Genet , vol.71 , pp. 1207-1215
    • Brody, L.C.1    Conley, M.2    Cox, C.3
  • 5
    • 10744222721 scopus 로고    scopus 로고
    • The thymidylate synthase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjects
    • Brown KS, Kluijtmans LA, Young IS, et al. 2004a. The thymidylate synthase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjects. Hum Genet 114:182-185.
    • (2004) Hum Genet , vol.114 , pp. 182-185
    • Brown, K.S.1    Kluijtmans, L.A.2    Young, I.S.3
  • 6
    • 2342528999 scopus 로고    scopus 로고
    • The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine
    • Brown KS, Kluijtmans LA, Young IS, et al. 2004b. The 5,10- methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine. Atherosclerosis 174:315-322.
    • (2004) Atherosclerosis , vol.174 , pp. 315-322
    • Brown, K.S.1    Kluijtmans, L.A.2    Young, I.S.3
  • 7
    • 66349099018 scopus 로고    scopus 로고
    • Preconceptional folate supplementation and the risk of spontaneous preterm birth: A cohort study
    • Bukowski R, Malone FD, Porter FT, et al. 2009. Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study. PLoS Med 6:e1000061.
    • (2009) PLoS Med , vol.6
    • Bukowski, R.1    Malone, F.D.2    Porter, F.T.3
  • 8
    • 0035864635 scopus 로고    scopus 로고
    • Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    • Chen J, Stampfer MJ, Ma J, et al. 2001. Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction. Atherosclerosis 154:667-672.
    • (2001) Atherosclerosis , vol.154 , pp. 667-672
    • Chen, J.1    Stampfer, M.J.2    Ma, J.3
  • 9
    • 0032104612 scopus 로고    scopus 로고
    • Periconceptional folic acid containing multivitamin supplementation
    • Czeizel AE. 1998. Periconceptional folic acid containing multivitamin supplementation. Eur J Obstet Gynecol Reprod Biol 78:151-161.
    • (1998) Eur J Obstet Gynecol Reprod Biol , vol.78 , pp. 151-161
    • Czeizel, A.E.1
  • 10
    • 0027080461 scopus 로고
    • Prevention of the first occurrence of neuraltube defects by periconceptional vitamin supplementation
    • Czeizel AE, Dudas I. 1992. Prevention of the first occurrence of neuraltube defects by periconceptional vitamin supplementation. N Engl J Med 327:1832-1835.
    • (1992) N Engl J Med , vol.327 , pp. 1832-1835
    • Czeizel, A.E.1    Dudas, I.2
  • 11
    • 0242669376 scopus 로고    scopus 로고
    • Reduced folate carrier polymorphism (80A->G) and neural tube defects
    • De Marco P, Calevo MG, Moroni A, et al. 2003. Reduced folate carrier polymorphism (80A->G) and neural tube defects. Eur J Hum Genet 11:245-252.
    • (2003) Eur J Hum Genet , vol.11 , pp. 245-252
    • De Marco, P.1    Calevo, M.G.2    Moroni, A.3
  • 12
    • 0036844005 scopus 로고    scopus 로고
    • Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida
    • Doolin MT, Barbaux S, McDonnell M, et al. 2002. Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida. Am J Hum Genet 71:1222-1226.
    • (2002) Am J Hum Genet , vol.71 , pp. 1222-1226
    • Doolin, M.T.1    Barbaux, S.2    McDonnell, M.3
  • 13
    • 34547746861 scopus 로고    scopus 로고
    • Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: A preliminary report
    • D'Uva M, Di Micco P, Strina I, et al. 2007. Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report. Thromb J 5:10.
    • (2007) Thromb J , vol.5 , pp. 10
    • D'Uva, M.1    Di Micco, P.2    Strina, I.3
  • 14
    • 0025837630 scopus 로고
    • A multivariate analysis of risk factors for preeclampsia
    • Eskenazi B, Fenster L, Sidney S, et al. 1991. A multivariate analysis of risk factors for preeclampsia. JAMA 266:237-241.
    • (1991) JAMA , vol.266 , pp. 237-241
    • Eskenazi, B.1    Fenster, L.2    Sidney, S.3
  • 15
    • 0032819943 scopus 로고    scopus 로고
    • Neural tube defect prevalence in California (1990-1994): Eliciting patterns by type of defect and maternal race/ethnicity
    • Feuchtbaum LB, Currier RJ, Riggle S, et al. 1999. Neural tube defect prevalence in California (1990-1994): eliciting patterns by type of defect and maternal race/ethnicity. Genet Test 3:265-272.
    • (1999) Genet Test , vol.3 , pp. 265-272
    • Feuchtbaum, L.B.1    Currier, R.J.2    Riggle, S.3
  • 16
    • 33646711216 scopus 로고    scopus 로고
    • Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults
    • Gabriel HE, Crott JW, Ghandour H, et al. 2006. Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults. Am J Clin Nutr 83:835-841.
    • (2006) Am J Clin Nutr , vol.83 , pp. 835-841
    • Gabriel, H.E.1    Crott, J.W.2    Ghandour, H.3
  • 17
    • 0034904708 scopus 로고    scopus 로고
    • The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations
    • Gaughan DJ, Kluijtmans LA, Barbaux S, et al. 2001. The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations. Atherosclerosis 157:451-456.
    • (2001) Atherosclerosis , vol.157 , pp. 451-456
    • Gaughan, D.J.1    Kluijtmans, L.A.2    Barbaux, S.3
  • 19
    • 0032713815 scopus 로고    scopus 로고
    • Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations
    • Harmon DL, Shields DC, Woodside JV, et al. 1999. Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet Epidemiol 17:298-309.
    • (1999) Genet Epidemiol , vol.17 , pp. 298-309
    • Harmon, D.L.1    Shields, D.C.2    Woodside, J.V.3
  • 20
    • 0029738540 scopus 로고    scopus 로고
    • The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia
    • Harmon DL, Woodside JV, Yarnell JW, et al. 1996. The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia. QJM 89:571-577.
    • (1996) QJM , vol.89 , pp. 571-577
    • Harmon, D.L.1    Woodside, J.V.2    Yarnell, J.W.3
  • 21
    • 74049105304 scopus 로고    scopus 로고
    • Annual summary of vital statistics: 2007
    • Heron M, Sutton PD, Xu J, et al. 2010. Annual summary of vital statistics: 2007. Pediatrics 125:4-15.
    • (2010) Pediatrics , vol.125 , pp. 4-15
    • Heron, M.1    Sutton, P.D.2    Xu, J.3
  • 22
    • 0035919139 scopus 로고    scopus 로고
    • Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects
    • Honein MA, Paulozzi LJ, Mathews TJ, et al. 2001. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 285:2981-2986.
    • (2001) JAMA , vol.285 , pp. 2981-2986
    • Honein, M.A.1    Paulozzi, L.J.2    Mathews, T.J.3
  • 23
    • 50249125272 scopus 로고    scopus 로고
    • Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry
    • Huang Y, Khartulyari S, Morales ME, et al. 2008. Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom 22:2403-2412.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , pp. 2403-2412
    • Huang, Y.1    Khartulyari, S.2    Morales, M.E.3
  • 24
    • 33846518884 scopus 로고    scopus 로고
    • Quantification of intracellular homocysteine by stable isotope dilution liquid chromatography/tandem mass spectrometry
    • Huang Y, Lu ZY, Brown KS, et al. 2007. Quantification of intracellular homocysteine by stable isotope dilution liquid chromatography/tandem mass spectrometry. Biomed Chromatogr 21:107-112.
    • (2007) Biomed Chromatogr , vol.21 , pp. 107-112
    • Huang, Y.1    Lu, Z.Y.2    Brown, K.S.3
  • 25
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • Jacques PF, Bostom AG, Williams RR, et al. 1996. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93:7-9.
    • (1996) Circulation , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3
  • 26
    • 0033551352 scopus 로고    scopus 로고
    • The effect of folic acid fortification on plasma folate and total homocysteine concentrations
    • Jacques PF, Selhub J, Bostom AG, et al. 1999. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 340:1449-1454.
    • (1999) N Engl J Med , vol.340 , pp. 1449-1454
    • Jacques, P.F.1    Selhub, J.2    Bostom, A.G.3
  • 27
    • 0032845227 scopus 로고    scopus 로고
    • Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
    • James SJ, Pogribna M, Pogribny IP, et al. 1999. Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr 70:495-501.
    • (1999) Am J Clin Nutr , vol.70 , pp. 495-501
    • James, S.J.1    Pogribna, M.2    Pogribny, I.P.3
  • 28
    • 0942290719 scopus 로고    scopus 로고
    • New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): A risk factor for spina bifida acting in mothers during pregnancy?
    • Johnson WG, Stenroos ES, Spychala JR, et al. 2004. New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy? Am J Med Genet A 124:339-345.
    • (2004) Am J Med Genet A , vol.124 , pp. 339-345
    • Johnson, W.G.1    Stenroos, E.S.2    Spychala, J.R.3
  • 29
    • 0023243925 scopus 로고
    • Homocysteinemia due to folate deficiency
    • Kang SS, Wong PW, Norusis M, et al. 1987. Homocysteinemia due to folate deficiency. Metabolism 36:458-462.
    • (1987) Metabolism , vol.36 , pp. 458-462
    • Kang, S.S.1    Wong, P.W.2    Norusis, M.3
  • 30
    • 20244362795 scopus 로고    scopus 로고
    • A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations
    • Kealey C, Brown KS, Woodside JV, et al. 2005. A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations. Hum Genet 116:347-353.
    • (2005) Hum Genet , vol.116 , pp. 347-353
    • Kealey, C.1    Brown, K.S.2    Woodside, J.V.3
  • 31
    • 3042784787 scopus 로고    scopus 로고
    • Impact of the MTHFR C677T polymorphism on risk of neural tube defects: Case-control study
    • Kirke PN, Mills JL, Molloy AM, et al. 2004. Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study. BMJ 328:1535-1536.
    • (2004) BMJ , vol.328 , pp. 1535-1536
    • Kirke, P.N.1    Mills, J.L.2    Molloy, A.M.3
  • 32
    • 34547978574 scopus 로고    scopus 로고
    • Dietary predictors of plasma total homocysteine in the Hordaland Homocysteine Study
    • Konstantinova SV, Vollset SE, Berstad P, et al. 2007. Dietary predictors of plasma total homocysteine in the Hordaland Homocysteine Study. Br J Nutr 98:201-210.
    • (2007) Br J Nutr , vol.98 , pp. 201-210
    • Konstantinova, S.V.1    Vollset, S.E.2    Berstad, P.3
  • 33
    • 48649107403 scopus 로고    scopus 로고
    • Folate and clefts of the lip and palate: A U.K.-based case-control study. Part II: Biochemical and genetic analysis
    • Little J, Gilmour M, Mossey PA, et al. 2008. Folate and clefts of the lip and palate: a U.K.-based case-control study. Part II: Biochemical and genetic analysis. Cleft Palate Craniofac J 45:428-438.
    • (2008) Cleft Palate Craniofac J , vol.45 , pp. 428-438
    • Little, J.1    Gilmour, M.2    Mossey, P.A.3
  • 34
    • 55449123755 scopus 로고    scopus 로고
    • Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor
    • Lu ZY, Morales M, Khartulyari S, et al. 2008. Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor. Birth Defects Res A Clin Mol Teratol 82:736-741.
    • (2008) Birth Defects Res A Clin Mol Teratol , vol.82 , pp. 736-741
    • Lu, Z.Y.1    Morales, M.2    Khartulyari, S.3
  • 35
    • 0033808685 scopus 로고    scopus 로고
    • Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes
    • Lucock M. 2000. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 71:121-138.
    • (2000) Mol Genet Metab , vol.71 , pp. 121-138
    • Lucock, M.1
  • 36
    • 0017162037 scopus 로고
    • Perinatal events associated with maternal smoking during pregnancy
    • Meyer MB, Jonas BS, Tonascia JA, et al. 1976. Perinatal events associated with maternal smoking during pregnancy. Am J Epidemiol 103:464-476.
    • (1976) Am J Epidemiol , vol.103 , pp. 464-476
    • Meyer, M.B.1    Jonas, B.S.2    Tonascia, J.A.3
  • 38
    • 0032581051 scopus 로고    scopus 로고
    • Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: Low folate status alone may be the critical factor
    • Molloy AM, Mills JL, Kirke PN, et al. 1998. Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10- methylenetetrahydrofolate reductase: low folate status alone may be the critical factor. Am J Med Genet 78:155-159.
    • (1998) Am J Med Genet , vol.78 , pp. 155-159
    • Molloy, A.M.1    Mills, J.L.2    Kirke, P.N.3
  • 39
    • 0037677623 scopus 로고    scopus 로고
    • Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk
    • Morin I, Devlin AM, Leclerc D, et al. 2003. Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk. Mol Genet Metab 79:197-200.
    • (2003) Mol Genet Metab , vol.79 , pp. 197-200
    • Morin, I.1    Devlin, A.M.2    Leclerc, D.3
  • 40
    • 0025863475 scopus 로고
    • Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
    • MRC Vitamin Study Research Group.
    • MRC Vitamin Study Research Group. 1991. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338:131-137.
    • (1991) Lancet , vol.338 , pp. 131-137
  • 41
    • 33744460203 scopus 로고    scopus 로고
    • Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population
    • Parle-McDermott A, Kirke PN, Mills JL, et al. 2006. Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population. Eur J Hum Genet 14:768-772.
    • (2006) Eur J Hum Genet , vol.14 , pp. 768-772
    • Parle-McDermott, A.1    Kirke, P.N.2    Mills, J.L.3
  • 42
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub J, Jacques PF, Wilson PW, et al. 1993. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270:2693-2698.
    • (1993) JAMA , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.3
  • 43
    • 4644243438 scopus 로고    scopus 로고
    • Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma
    • Skibola CF, Forrest MS, Coppede F, et al. 2004. Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma. Blood 104:2155-2162.
    • (2004) Blood , vol.104 , pp. 2155-2162
    • Skibola, C.F.1    Forrest, M.S.2    Coppede, F.3
  • 44
    • 0037093272 scopus 로고    scopus 로고
    • Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia
    • Skibola CF, Smith MT, Hubbard A, et al. 2002. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood 99:3786-3791.
    • (2002) Blood , vol.99 , pp. 3786-3791
    • Skibola, C.F.1    Smith, M.T.2    Hubbard, A.3
  • 45
    • 41149145923 scopus 로고    scopus 로고
    • An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
    • Stanislawska-Sachadyn A, Brown KS, Mitchell LE, et al. 2008a. An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women. Hum Genet 123:289-295.
    • (2008) Hum Genet , vol.123 , pp. 289-295
    • Stanislawska-Sachadyn, A.1    Brown, K.S.2    Mitchell, L.E.3
  • 46
    • 68549104398 scopus 로고    scopus 로고
    • The reduced folate carrier (SLC19A1) c. 80G>A polymorphism is associated with red cell folate concentrations among women
    • Stanislawska-Sachadyn A, Mitchell LE, Woodside JV, et al. 2009. The reduced folate carrier (SLC19A1) c. 80G>A polymorphism is associated with red cell folate concentrations among women. Ann Hum Genet 73:484-491.
    • (2009) Ann Hum Genet , vol.73 , pp. 484-491
    • Stanislawska-Sachadyn, A.1    Mitchell, L.E.2    Woodside, J.V.3
  • 47
    • 40849126757 scopus 로고    scopus 로고
    • Evidence for sex differences in the determinants of homocysteine concentrations
    • Stanislawska-Sachadyn A, Woodside JV, Brown KS, et al. 2008b. Evidence for sex differences in the determinants of homocysteine concentrations. Mol Genet Metab 93:355-362.
    • (2008) Mol Genet Metab , vol.93 , pp. 355-362
    • Stanislawska-Sachadyn, A.1    Woodside, J.V.2    Brown, K.S.3
  • 48
    • 3142774934 scopus 로고    scopus 로고
    • Physiology of folate and vitamin B12 in health and disease
    • discussion S13
    • Stover PJ. 2004. Physiology of folate and vitamin B12 in health and disease. Nutr Rev 62:S3-12; discussion S13.
    • (2004) Nutr Rev , vol.62
    • Stover, P.J.1
  • 49
    • 56449130924 scopus 로고    scopus 로고
    • Functional polymorphisms of folate-metabolizing enzymes in relation to homocysteine concentrations in systemic lupus erythematosus
    • Summers CM, Cucchiara AJ, Nackos E, et al. 2008. Functional polymorphisms of folate-metabolizing enzymes in relation to homocysteine concentrations in systemic lupus erythematosus. J Rheumatol 35:2179-2186.
    • (2008) J Rheumatol , vol.35 , pp. 2179-2186
    • Summers, C.M.1    Cucchiara, A.J.2    Nackos, E.3
  • 50
    • 77951628918 scopus 로고    scopus 로고
    • Lifestyle and genetic determinants of folate and vitamin B12 levels in a general adult population
    • Thuesen BH, Husemoen LL, Ovesen L, et al. 2010. Lifestyle and genetic determinants of folate and vitamin B12 levels in a general adult population. Br J Nutr 103:1195-1204.
    • (2010) Br J Nutr , vol.103 , pp. 1195-1204
    • Thuesen, B.H.1    Husemoen, L.L.2    Ovesen, L.3
  • 51
    • 73749084803 scopus 로고    scopus 로고
    • Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: The Generation R Study
    • Timmermans S, Jaddoe VW, Hofman A, et al. 2009. Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: the Generation R Study. Br J Nutr 102:777-785.
    • (2009) Br J Nutr , vol.102 , pp. 777-785
    • Timmermans, S.1    Jaddoe, V.W.2    Hofman, A.3
  • 52
    • 0036765747 scopus 로고    scopus 로고
    • Thymidylate synthase: A novel genetic determinant of plasma homocysteine and folate levels
    • Trinh BN, Ong CN, Coetzee GA, et al. 2002. Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels. Hum Genet 111:299-302.
    • (2002) Hum Genet , vol.111 , pp. 299-302
    • Trinh, B.N.1    Ong, C.N.2    Coetzee, G.A.3
  • 53
    • 0033999287 scopus 로고    scopus 로고
    • Polygenic influence on plasma homocysteine: Association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels
    • Tsai MY, Bignell M, Yang F, et al. 2000. Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels. Atherosclerosis 149:131-137.
    • (2000) Atherosclerosis , vol.149 , pp. 131-137
    • Tsai, M.Y.1    Bignell, M.2    Yang, F.3
  • 54
    • 33947239251 scopus 로고    scopus 로고
    • Functional inference of the methylenetetrahydrofolate reductase 677C>T and 1298A>C polymorphisms from a large-scale epidemiological study
    • Ulvik A, Ueland PM, Fredriksen A, et al. 2007. Functional inference of the methylenetetrahydrofolate reductase 677C>T and 1298A>C polymorphisms from a large-scale epidemiological study. Hum Genet 121:57-64.
    • (2007) Hum Genet , vol.121 , pp. 57-64
    • Ulvik, A.1    Ueland, P.M.2    Fredriksen, A.3
  • 55
    • 0028844492 scopus 로고
    • Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
    • van der Put NM, Steegers-Theunissen RP, Frosst P, et al. 1995. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346:1070-1071.
    • (1995) Lancet , vol.346 , pp. 1070-1071
    • Van Der Put, N.M.1    Steegers-Theunissen, R.P.2    Frosst, P.3
  • 57
    • 0034073977 scopus 로고    scopus 로고
    • Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: The Hordaland Homocysteine study
    • Vollset SE, Refsum H, Irgens LM, et al. 2000. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am J Clin Nutr 71:962-968.
    • (2000) Am J Clin Nutr , vol.71 , pp. 962-968
    • Vollset, S.E.1    Refsum, H.2    Irgens, L.M.3
  • 58
    • 0028803474 scopus 로고
    • A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects
    • Whitehead AS, Gallagher P, Mills JL, et al. 1995. A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects. QJM 88:763-766.
    • (1995) QJM , vol.88 , pp. 763-766
    • Whitehead, A.S.1    Gallagher, P.2    Mills, J.L.3
  • 59
    • 0036019274 scopus 로고    scopus 로고
    • Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States
    • Williams LJ, Mai CT, Edmonds LD, et al. 2002. Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States. Teratology 66:33-39.
    • (2002) Teratology , vol.66 , pp. 33-39
    • Williams, L.J.1    Mai, C.T.2    Edmonds, L.D.3
  • 60
    • 0032856882 scopus 로고    scopus 로고
    • A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida
    • Wilson A, Platt R, Wu Q, et al. 1999. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab 67:317-323.
    • (1999) Mol Genet Metab , vol.67 , pp. 317-323
    • Wilson, A.1    Platt, R.2    Wu, Q.3
  • 61
    • 0030941305 scopus 로고    scopus 로고
    • Maternal cigarette smoking and oral clefts: A meta-analysis
    • Wyszynski DF, Duffy DL, Beaty TH, et al. 1997. Maternal cigarette smoking and oral clefts: a meta-analysis. Cleft Palate Craniofac J 34:206-210.
    • (1997) Cleft Palate Craniofac J , vol.34 , pp. 206-210
    • Wyszynski, D.F.1    Duffy, D.L.2    Beaty, T.H.3
  • 62
    • 0031049636 scopus 로고    scopus 로고
    • Does periconceptional multivitamin use reduce the risk for limb deficiency in offspring?
    • Yang Q, Khoury MJ, Olney RS, et al. 1997. Does periconceptional multivitamin use reduce the risk for limb deficiency in offspring? Epidemiology 8:157-161.
    • (1997) Epidemiology , vol.8 , pp. 157-161
    • Yang, Q.1    Khoury, M.J.2    Olney, R.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.