Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: The Generation R Study

British Journal of Nutrition

Volumn 102, Issue 5, 2009, Pages 777-785

  Timmermans, Sarah ^a   Jaddoe, Vincent W V ^a   Hofman, Albert ^a   Steegers Theunissen, Régine P M ^a   Steegers, Eric A P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Birth weight; Effect modification; Epigenetics; Folate

Indexed keywords

FOLIC ACID;

ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; FETUS ECHOGRAPHY; FETUS GROWTH; HUMAN; LOW BIRTH WEIGHT; PARITY; PERINATAL PERIOD; PLACENTA WEIGHT; PREGNANCY; PREMATURITY; RISK REDUCTION; SMALL FOR DATE INFANT; SUPPLEMENTATION;

ADOLESCENT; ADULT; BIRTH WEIGHT; DIETARY SUPPLEMENTS; EDUCATIONAL STATUS; ETHNIC GROUPS; FEMALE; FERTILIZATION; FETAL DEVELOPMENT; FOLIC ACID; FOOD, FORTIFIED; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; MATERNAL AGE; NETHERLANDS; PARITY; PREGNANCY; SMOKING; YOUNG ADULT;

EID: 73749084803     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509288994     Document Type: Article

References (54)

1. Barker DJ & Clark PM (1997) Foetal undernutrition and disease in later life. Rev Reprod 2, 105-112.
2. Roseboom T, de Rooij S & Painter R (2006) The Dutch famine and its long-term consequences for adult health. Early Hum Dev 82, 485-491.
3. Wu G, Bazer FW, Cudd TA, et al. (2004) Maternal nutrition and foetal development. J Nutr 134, 2169-2172.
4. Steegers-TheunissenRPM(1995) Maternal nutrition and obstetric outcome. In Clinical Obstetrics and Gynaecology. Preventive Care in Obstetrics, Vol.9, pp. 431-445 [EAP Steegers, TKAB Eskes and EM Symonds, editors]. London: Baillière Tindal.
5. Barker DJ (1994) Mothers, Babies and Disease in Later Life. London: BMJ Publishing Group.
6. Hoet JJ & Hanson MA (1999) Intrauterine nutrition: Its importance during critical periods for cardiovascular and endocrine development. J Physiol 514, 617-627.
7. Steegers-Theunissen RP & Steegers EA (2003) Nutrient-gene interactions in early pregnancy: A vascular hypothesis. Eur J Obstet Gynecol Reprod Biol 106, 115-117.
8. Waterland RA & Jirtle RL (2004) Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20, 63-68.
9. Heijmans BT, Tobi EW, Stein AD, et al. (2008) Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A 105, 17046-17049.
10. Tamura T & Picciano MF (2006) Folate and human reproduction. Am J Clin Nutr 83, 993-1016.
11. Bailey LB & Gregory JF III (1999) Folate metabolism and requirements. J Nutr 129, 779-782.
12. MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study. Lancet 338, 131-137.
13. Czeizel AE & Dudas I (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327, 1832-1835.
14. Hernandez-Diaz S, Werler MM, Walker AM, et al. (2000) Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med 343, 1608-1614.
15. Hibbard BM (1964) The role of folic acid in pregnancy; with particular reference to anaemia, abruption and abortion. J Obstet Gynaecol Br Commonw 71, 529-542.
16. Steegers-Theunissen RP, Boers GH, Blom HJ, et al. (1992) Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. Lancet 339, 1122-1123.
17. de Bree A, van Dusseldorp M, Brouwer IA, et al. (1997) Folate intake in Europe: Recommended, actual and desired intake. Eur J Clin Nutr 51, 643-660.
18. Botto LD, Lisi A, Robert-Gnansia E, et al. (2005) International retrospective cohort study of neural tube defects in relation to folic acid recommendations: Are the recommendations working? Br Med J 330, 571.
19. Baumslag N, Edelstein T & Metz J (1970) Reduction of incidence of prematurity by folic acid supplementation in pregnancy. Br Med J 1, 16-17.
20. Goldenberg RL, Tamura T, Cliver SP, et al. (1992) Serum folate and foetal growth retardation: A matter of compliance? Obstet Gynecol 79, 719-722.
21. Iyengar L & Rajalakshmi K (1975) Effect of folic acid supplement on birth weights of infants. Am J Obstet Gynecol 122, 332-336.
22. Rolschau J, Date J & Kristoffersen K (1979) Folic acid supplement and intrauterine growth. Acta Obstet Gynecol Scand 58, 343-346.
23. Rolschau J, Kristoffersen K, Ulrich M, et al. (1999) The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark. Part I. Eur J Obstet Gynecol Reprod Biol 87, 105-110.
24. Scholl TO, Hediger ML, Schall JI, et al. (1996) Dietary and serum folate: Their influence on the outcome of pregnancy. Am J Clin Nutr 63, 520-525.
25. Tamura T, Goldenberg RL, Freeberg LE, et al. (1992) Maternal serum folate and zinc concentrations and their relationships to pregnancy outcome. Am J Clin Nutr 56, 365-370.
26. Neggers YH, Goldenberg RL, Tamura T, et al. (1997) The relationship between maternal dietary intake and infant birthweight. Acta Obstet Gynecol Scand 165, Suppl., 71-75.
27. Fawzi WW, Msamanga GI, Urassa W, et al. (2007) Vitamins and perinatal outcomes among HIV-negative women in Tanzania. N Engl J Med 356, 1423-1431. (Pubitemid 46556327)
28. Ronnenberg AG, Goldman MB, Chen D, et al. (2002) Preconception homocysteine and B vitamin status and birth outcomes in Chinese women. Am J Clin Nutr 76, 1385-1391.
29. Sinclair KD, Allegrucci C, Singh R, et al. (2007) DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A 104, 19351-19356.
30. Rosenquist TH & Finnell RH (2001) Genes, folate and homocysteine in embryonic development. Proc Nutr Soc 60, 53-61.
31. Jaddoe VW, Bakker R, van Duijn CM, et al. (2007) The Generation R Study Biobank: A resource for epidemiological studies in children and their parents. Eur J Epidemiol 22, 917-923.
32. Jaddoe VW, Mackenbach JP, Moll HA, et al. (2006) The Generation R Study: Design and cohort profile. Eur J Epidemiol 21, 475-484.
33. Voedingsraad/Gezondheidsraad (1992) Advies inzake Foliumzuurvoorziening in relatie tot neuralebuisdefecten. Den Haag: Voorlichtingsbureau voor de Voeding.
34. Voedingsraad/Gezondheidsraad (1993) Vervolgadvies inzake Foliumzuurvoorziening in relatie tot neuralebuisdefecten. Den Haag: Voorlichtingsbureau voor de Voeding.
35. Verburg BO, Steegers EA, De Ridder M, et al. (2008) New charts for ultrasound dating of pregnancy and assessment of foetal growth: longitudinal data from a population-based cohort study. Ultrasound Obstet Gynecol 31, 388-396.
36. Hadlock FP, Harrist RB, Sharman RS, et al. (1985) Estimation of foetal weight with the use of head, body, and femur measurements-a prospective study. Am J Obstet Gynecol 151, 333-337.
37. Bleker OP, Buimer M, van der Post JA, et al. (2006) Ted (G.J.) Kloosterman: On intrauterine growth. The significance of prenatal care. Studies on birth weight, placental weight and placental index. Placenta 27, 1052-1054.
38. Kloosterman GJ (1970) On intrauterine growth. The significance of prenatal care. Int J Gynaecol Obstet 8, 895-912.
39. Statistics Netherlands (2004) Standaard onderwijs indeling 2003. Voorburg/Heerlen: Statistics Netherlands.
40. Statistics Netherlands (2004) Allochtonen in Nederland 2004. Voorburg/Heerlen: Statistics Netherlands.
41. Kramer MS (1987) Determinants of low birth weight: Methodological assessment and meta-analysis. Bull World Health Organ 65, 663-737.
42. Timmermans S, Jaddoe VW, Mackenbach JP, et al. (2008) Determinants of folic acid use in early pregnancy in a multiethnic urban population in The Netherlands: The Generation R study. Prev Med 47, 427-432.
43. Cunningham FG, Gant NF & Leveno KJ (1997) Foetal growth disorders. In Williams Obstetrics 1997, 21st ed., pp. 743-764 [FG Cunningham, NF Gant and KJ Leveno, editors]. New York: Appleton and Lange.
44. Palma S, Perez-Iglesias R, Prieto D, et al. (2008) Iron but not folic acid supplementation reduces the risk of low birthweight in pregnant women without anaemia: A case control study. J Epidemiol Community Health 62, 120-124.
45. van der Molen EF, Verbruggen B, Novakova I, et al. (2000) Hyperhomocysteinemia and other thrombotic risk factors in women with placental vasculopathy. BJOG 107, 785-791.
46. Nafee TM, Farrell WE, Carroll WD, et al. (2008) Epigenetic control of foetal gene expression. BJOG 115, 158-168.
47. Waterland RA & Michels KB (2007) Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr 27, 363-388.
48. Pennisi E (2005) Environmental epigenomics meeting. Supplements restore gene function via methylation. Science 310, 1761.
49. Kloosterman GJ (1956) Prolonged pregnancy. Gynaecologia 142, 372-388.
50. Kloosterman GJ & Huidekoper BL (1954) The significance of the placenta in obstetrical mortality; a study of 2000 births. Gynaecologia 138, 529-550.
51. van Delft M & Ketting E (2002) Anticonceptiegebruik in Nederland. Houten: Bohn Stafleu van Loghum.
52. Hoggatt KJ (2003) Commentary: Vitamin supplement use and confounding by lifestyle. Int J Epidemiol 32, 553-555.
53. Brantsaeter AL, Haugen M, Hagve TA, et al. (2007) Selfreported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa). Ann Nutr Metab 51, 146-154.
54. Bendich A (1991) Importance of vitamin status to pregnancy outcomes. In Micronutrients in Health and in Disease Prevention, pp. 235-262 [A Bendich and CE Butterworch Jr, editors]. New York: Marcel Dekker